Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978596306> ?p ?o ?g. }
- W1978596306 endingPage "8041" @default.
- W1978596306 startingPage "8036" @default.
- W1978596306 abstract "Whether long interspersed element-1 (L1 or LINE-1) retrotransposition can occur in quiescent, nondividing, and/or terminally differentiated somatic cells has remained an unanswered fundamental question in human genetics. Here, we used a ubiquitously active phosphoglycerate kinase-1 promoter to drive the expression of a highly active human L1 element from an adenovirus-L1 hybrid vector. This vector system achieved retrotransposition in up to 91% of actively growing immortalized cells, and we demonstrated that L1 retrotransposition can be suppressed by the reverse transcriptase inhibitor 3'-azido-3'-deoxythymidine. This adenovirus vector enabled efficient delivery of the L1 element into differentiated primary human somatic cells and G1/S-arrested cells, resulting in retrotransposition in both cases; however, it was not detected in G0-arrested cells. Thus, these data indicate that L1 retrotransposition can occur in nondividing somatic cells." @default.
- W1978596306 created "2016-06-24" @default.
- W1978596306 creator A5015193605 @default.
- W1978596306 creator A5016025349 @default.
- W1978596306 creator A5023851948 @default.
- W1978596306 creator A5039653400 @default.
- W1978596306 creator A5040935531 @default.
- W1978596306 creator A5064084333 @default.
- W1978596306 creator A5066019350 @default.
- W1978596306 date "2006-05-23" @default.
- W1978596306 modified "2023-10-14" @default.
- W1978596306 title "L1 retrotransposition in nondividing and primary human somatic cells" @default.
- W1978596306 cites W1509378838 @default.
- W1978596306 cites W1565206912 @default.
- W1978596306 cites W1566969252 @default.
- W1978596306 cites W1582533438 @default.
- W1978596306 cites W1593362658 @default.
- W1978596306 cites W1594848307 @default.
- W1978596306 cites W1780040755 @default.
- W1978596306 cites W1944771638 @default.
- W1978596306 cites W1971130409 @default.
- W1978596306 cites W1991333931 @default.
- W1978596306 cites W1996052749 @default.
- W1978596306 cites W2002190096 @default.
- W1978596306 cites W2009761723 @default.
- W1978596306 cites W2010426022 @default.
- W1978596306 cites W2012537642 @default.
- W1978596306 cites W2015415562 @default.
- W1978596306 cites W2029531342 @default.
- W1978596306 cites W2044296969 @default.
- W1978596306 cites W2049846352 @default.
- W1978596306 cites W2050557699 @default.
- W1978596306 cites W2064629259 @default.
- W1978596306 cites W2070807615 @default.
- W1978596306 cites W2090945464 @default.
- W1978596306 cites W2096000931 @default.
- W1978596306 cites W2102773855 @default.
- W1978596306 cites W2113973815 @default.
- W1978596306 cites W2114161855 @default.
- W1978596306 cites W2114766453 @default.
- W1978596306 cites W2118155162 @default.
- W1978596306 cites W2119742125 @default.
- W1978596306 cites W2133731756 @default.
- W1978596306 cites W2134924469 @default.
- W1978596306 cites W2135478494 @default.
- W1978596306 cites W2144623802 @default.
- W1978596306 cites W2150649207 @default.
- W1978596306 cites W2152204052 @default.
- W1978596306 cites W2153586836 @default.
- W1978596306 cites W2154853638 @default.
- W1978596306 cites W2155264063 @default.
- W1978596306 cites W2160743112 @default.
- W1978596306 cites W2168676279 @default.
- W1978596306 cites W4237165615 @default.
- W1978596306 cites W4243432010 @default.
- W1978596306 doi "https://doi.org/10.1073/pnas.0601954103" @default.
- W1978596306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1472425" @default.
- W1978596306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16698926" @default.
- W1978596306 hasPublicationYear "2006" @default.
- W1978596306 type Work @default.
- W1978596306 sameAs 1978596306 @default.
- W1978596306 citedByCount "164" @default.
- W1978596306 countsByYear W19785963062012 @default.
- W1978596306 countsByYear W19785963062013 @default.
- W1978596306 countsByYear W19785963062014 @default.
- W1978596306 countsByYear W19785963062015 @default.
- W1978596306 countsByYear W19785963062016 @default.
- W1978596306 countsByYear W19785963062017 @default.
- W1978596306 countsByYear W19785963062018 @default.
- W1978596306 countsByYear W19785963062019 @default.
- W1978596306 countsByYear W19785963062020 @default.
- W1978596306 countsByYear W19785963062021 @default.
- W1978596306 countsByYear W19785963062022 @default.
- W1978596306 countsByYear W19785963062023 @default.
- W1978596306 crossrefType "journal-article" @default.
- W1978596306 hasAuthorship W1978596306A5015193605 @default.
- W1978596306 hasAuthorship W1978596306A5016025349 @default.
- W1978596306 hasAuthorship W1978596306A5023851948 @default.
- W1978596306 hasAuthorship W1978596306A5039653400 @default.
- W1978596306 hasAuthorship W1978596306A5040935531 @default.
- W1978596306 hasAuthorship W1978596306A5064084333 @default.
- W1978596306 hasAuthorship W1978596306A5066019350 @default.
- W1978596306 hasBestOaLocation W19785963062 @default.
- W1978596306 hasConcept C104317684 @default.
- W1978596306 hasConcept C134305767 @default.
- W1978596306 hasConcept C141231307 @default.
- W1978596306 hasConcept C153911025 @default.
- W1978596306 hasConcept C40767141 @default.
- W1978596306 hasConcept C4918238 @default.
- W1978596306 hasConcept C54355233 @default.
- W1978596306 hasConcept C7029365 @default.
- W1978596306 hasConcept C81885089 @default.
- W1978596306 hasConcept C86803240 @default.
- W1978596306 hasConcept C92087593 @default.
- W1978596306 hasConcept C95444343 @default.
- W1978596306 hasConceptScore W1978596306C104317684 @default.
- W1978596306 hasConceptScore W1978596306C134305767 @default.
- W1978596306 hasConceptScore W1978596306C141231307 @default.