FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978596328> ?p ?o ?g. }

• W1978596328 endingPage "261" @default.
• W1978596328 startingPage "243" @default.
• W1978596328 abstract "Transforming growth factor alpha (TGFα) interacts with the epidermal growth factor receptor (EGF-R) to produce its biological effects. TGFα induces the proliferation and differentiation of central nervous system (CNS) astrocytes and pluripotent stem cells, as well as the survival and differentiation of postmitotic CNS neurons. Both TGFα and EGF-R have been localized to the postnatal CNS. As the majority of CNS neuronal proliferation and migration occurs antenatally, we have examined the ontogeny of TGFα and EGF-R in the embryonic rat brain by in situ hybridization. EGF-R mRNA was expressed in the brain as early as embryonic day 11 (E11; the earliest age examined). It was initially detected in the midbrain, with subsequent expression first in multiple germinal zones, followed by expression in numerous cells throughout the brain. In many brain areas, EGF-R mRNA appeared in germinal centers during the later stages of neurogenesis and the early stages of gliogenesis. In the midbrain, the distribution of EGF-R mRNA overlapped extensively with that of tyrosine hydroxylase mRNA, suggesting that fetal dopaminergic neurons express EGF-R. Immunocytochemistry was used to demonstrate the presence of EGF-R-immunoreactive protein in brain areas that expressed EGF-R mRNA on E15 and E20. The expression of TGFα in many brain structures preceded that of EGF-R mRNA. TGFα mRNA was distributed throughout many non-germinal centers of the brain on E12 and later. Some brain areas, such as the external granule cell layer of the cerebellum, expressed EGF-R, but not TGFα mRNA. Northern blot analysis demonstrated that mRNA species for both TGFα and EGF-R were similar in embryos and adults. These data indicate that TGFα and EGF-R are positioned to have a role in the genesis, differentiation, migration, or survival of numerous cell populations in the embryonic brain. J. Comp. Neurol. 380:243–261, 1997. © 1997 Wiley-Liss, Inc." @default.
• W1978596328 created "2016-06-24" @default.
• W1978596328 creator A5004377423 @default.
• W1978596328 creator A5016423162 @default.
• W1978596328 creator A5047439852 @default.
• W1978596328 creator A5062310885 @default.
• W1978596328 creator A5073284312 @default.
• W1978596328 creator A5087513646 @default.
• W1978596328 date "1997-04-07" @default.
• W1978596328 modified "2023-10-12" @default.
• W1978596328 title "Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain" @default.
• W1978596328 cites W1494997792 @default.
• W1978596328 cites W1538741464 @default.
• W1978596328 cites W1545662949 @default.
• W1978596328 cites W1562089313 @default.
• W1978596328 cites W1775329494 @default.
• W1978596328 cites W1966864860 @default.
• W1978596328 cites W1969208902 @default.
• W1978596328 cites W1969311327 @default.
• W1978596328 cites W1982922725 @default.
• W1978596328 cites W1983350374 @default.
• W1978596328 cites W1999213801 @default.
• W1978596328 cites W1999368094 @default.
• W1978596328 cites W2001726390 @default.
• W1978596328 cites W2004831331 @default.
• W1978596328 cites W2010398513 @default.
• W1978596328 cites W2013580165 @default.
• W1978596328 cites W2015325818 @default.
• W1978596328 cites W2020676683 @default.
• W1978596328 cites W2021954193 @default.
• W1978596328 cites W2022583663 @default.
• W1978596328 cites W2026401160 @default.
• W1978596328 cites W2026904817 @default.
• W1978596328 cites W2030508161 @default.
• W1978596328 cites W2046755924 @default.
• W1978596328 cites W2050329524 @default.
• W1978596328 cites W2062428455 @default.
• W1978596328 cites W2063784792 @default.
• W1978596328 cites W2064521170 @default.
• W1978596328 cites W2066093703 @default.
• W1978596328 cites W2067376187 @default.
• W1978596328 cites W2071656982 @default.
• W1978596328 cites W2071894629 @default.
• W1978596328 cites W2076745990 @default.
• W1978596328 cites W2077719618 @default.
• W1978596328 cites W2078342447 @default.
• W1978596328 cites W2079356804 @default.
• W1978596328 cites W2080510783 @default.
• W1978596328 cites W2080692154 @default.
• W1978596328 cites W2086589412 @default.
• W1978596328 cites W2090077609 @default.
• W1978596328 cites W2092910281 @default.
• W1978596328 cites W2094583056 @default.
• W1978596328 cites W2095129531 @default.
• W1978596328 cites W2097732565 @default.
• W1978596328 cites W2103824972 @default.
• W1978596328 cites W2104789206 @default.
• W1978596328 cites W2123667883 @default.
• W1978596328 cites W2128454299 @default.
• W1978596328 cites W2137584473 @default.
• W1978596328 cites W2148319533 @default.
• W1978596328 cites W2151947623 @default.
• W1978596328 cites W2161344190 @default.
• W1978596328 cites W2167334523 @default.
• W1978596328 cites W2313159234 @default.
• W1978596328 cites W2399797271 @default.
• W1978596328 doi "https://doi.org/10.1002/(sici)1096-9861(19970407)380:2<243::aid-cne7>3.0.co;2-3" @default.
• W1978596328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9100135" @default.
• W1978596328 hasPublicationYear "1997" @default.
• W1978596328 type Work @default.
• W1978596328 sameAs 1978596328 @default.
• W1978596328 citedByCount "157" @default.
• W1978596328 countsByYear W19785963282012 @default.
• W1978596328 countsByYear W19785963282013 @default.
• W1978596328 countsByYear W19785963282014 @default.
• W1978596328 countsByYear W19785963282015 @default.
• W1978596328 countsByYear W19785963282016 @default.
• W1978596328 countsByYear W19785963282017 @default.
• W1978596328 countsByYear W19785963282018 @default.
• W1978596328 countsByYear W19785963282019 @default.
• W1978596328 countsByYear W19785963282020 @default.
• W1978596328 countsByYear W19785963282021 @default.
• W1978596328 countsByYear W19785963282022 @default.
• W1978596328 countsByYear W19785963282023 @default.
• W1978596328 crossrefType "journal-article" @default.
• W1978596328 hasAuthorship W1978596328A5004377423 @default.
• W1978596328 hasAuthorship W1978596328A5016423162 @default.
• W1978596328 hasAuthorship W1978596328A5047439852 @default.
• W1978596328 hasAuthorship W1978596328A5062310885 @default.
• W1978596328 hasAuthorship W1978596328A5073284312 @default.
• W1978596328 hasAuthorship W1978596328A5087513646 @default.
• W1978596328 hasConcept C104317684 @default.
• W1978596328 hasConcept C105580179 @default.
• W1978596328 hasConcept C118131993 @default.
• W1978596328 hasConcept C125555471 @default.
• W1978596328 hasConcept C126322002 @default.
• W1978596328 hasConcept C134018914 @default.
• W1978596328 hasConcept C136834591 @default.

• next