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• W1978601326 abstract "The development of neuromuscular junction (NMJ) is initiated by motor axon's contact with the skeletal muscle cell that is followed by synaptic maturation. Previous studies showed that brain-derived neurotrophic factor (BDNF) enhanced motoneurons' survival and growth but significantly inhibited synaptogenesis. Here, we report that chronic application of BDNF resulted in inhibition in the maturation process both physiologically and morphologically. The response to BDNF was mediated by its cognate receptor TrkB as the effects were abolished by Trk receptor inhibitor K252a. Protein kinase A (PKA) inhibitor reversed the effects of BDNF in inhibiting NMJ maturation. These results indicate that BDNF suppresses NMJ maturation through cAMP-PKA signaling pathway. Together with the previous studies, these results suggest that BDNF suppresses NMJ formation and maturation despite its effects in enhancing neuronal survival and growth." @default.
• W1978601326 created "2016-06-24" @default.
• W1978601326 creator A5024839489 @default.
• W1978601326 creator A5049326622 @default.
• W1978601326 date "2015-03-01" @default.
• W1978601326 modified "2023-10-03" @default.
• W1978601326 title "Brain-derived neurotrophic factor inhibits neuromuscular junction maturation in a cAMP-PKA-dependent way" @default.
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• W1978601326 doi "https://doi.org/10.1016/j.neulet.2015.02.019" @default.
• W1978601326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25681622" @default.
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