FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978602103> ?p ?o ?g. }

• W1978602103 endingPage "e0117429" @default.
• W1978602103 startingPage "e0117429" @default.
• W1978602103 abstract "High rate of viral replication and lacking of proofreading activity in hepatitis B virus (HBV) polymerase lead to the generation of mutations in HBV virus. Mutations in the reverse transcriptase (RT) region of HBV polymerase are demonstrated to be strongly associated with drug resistance during antiviral treatment. However, the presence of mutations as well as its clinical significance in treatment-naïve hepatitis patients (defined as pre-existing mutations) need to be further investigated. In the present study, a total of 168 serum samples from treatment-naive chronic hepatitis B (CHB) patients were collected, and the RT region of HBV polymerase was sequenced. The results showed that pre-existing mutations in the RT region of HBV polymerase were detected in 43 of 168 (25.6%) treatment-naive CHB patients within which there were no well-characterized primary nucleotide analogs (NAs) resistance sites. Three dominant sites at rt191, rt207 and rt226 were found mutant in 7(16.28%), 8(18.60%), and 14(32.56%) samples respectively among these 43 patients. No significant correlation was found between pre-existing mutations and gender, age, HBV genotype, ALT, HBeAg or HBV DNA loads. However, patients with pre-existing RT mutations under HBeAg sero-negative status exhibited decreased HBV DNA loads, which contributed to the decreased HBV DNA loads in the total HBeAg sero-negative patients. The above investigation indicated that there was a prevalence of pre-existing mutations in RT region of HBV polymerase which might affect the serum HBV DNA level in treatment-naive CHB patients. Its effects on the occurrence of NAs resistance and the prognosis after treatment need to be further investigated." @default.
• W1978602103 created "2016-06-24" @default.
• W1978602103 creator A5009811665 @default.
• W1978602103 creator A5012803702 @default.
• W1978602103 creator A5021173497 @default.
• W1978602103 creator A5022141624 @default.
• W1978602103 creator A5041690571 @default.
• W1978602103 creator A5047289105 @default.
• W1978602103 creator A5052871114 @default.
• W1978602103 creator A5091083080 @default.
• W1978602103 date "2015-03-30" @default.
• W1978602103 modified "2023-10-06" @default.
• W1978602103 title "Pre-Existing Mutations in Reverse Transcriptase of Hepatitis B Virus in Treatment-Naive Chinese Patients with Chronic Hepatitis B" @default.
• W1978602103 cites W141336275 @default.
• W1978602103 cites W1492134529 @default.
• W1978602103 cites W1572444605 @default.
• W1978602103 cites W1813446025 @default.
• W1978602103 cites W1925166918 @default.
• W1978602103 cites W1968913867 @default.
• W1978602103 cites W1972594988 @default.
• W1978602103 cites W1976104517 @default.
• W1978602103 cites W1978314081 @default.
• W1978602103 cites W1991592276 @default.
• W1978602103 cites W1992691024 @default.
• W1978602103 cites W2000618086 @default.
• W1978602103 cites W2006698257 @default.
• W1978602103 cites W2012774039 @default.
• W1978602103 cites W2023559661 @default.
• W1978602103 cites W2027280548 @default.
• W1978602103 cites W2043882045 @default.
• W1978602103 cites W2044553804 @default.
• W1978602103 cites W2044951291 @default.
• W1978602103 cites W2046910181 @default.
• W1978602103 cites W2065861953 @default.
• W1978602103 cites W2075595885 @default.
• W1978602103 cites W2082120216 @default.
• W1978602103 cites W2082326693 @default.
• W1978602103 cites W2088354185 @default.
• W1978602103 cites W2099690830 @default.
• W1978602103 cites W2101164606 @default.
• W1978602103 cites W2109848199 @default.
• W1978602103 cites W2110747022 @default.
• W1978602103 cites W2118434108 @default.
• W1978602103 cites W2121003115 @default.
• W1978602103 cites W2125690358 @default.
• W1978602103 cites W2126494596 @default.
• W1978602103 cites W2142861964 @default.
• W1978602103 cites W2143501119 @default.
• W1978602103 cites W2143951155 @default.
• W1978602103 cites W2144094774 @default.
• W1978602103 cites W2155121350 @default.
• W1978602103 cites W2172178693 @default.
• W1978602103 cites W2325799013 @default.
• W1978602103 cites W2395270293 @default.
• W1978602103 cites W82357978 @default.
• W1978602103 doi "https://doi.org/10.1371/journal.pone.0117429" @default.
• W1978602103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4379075" @default.
• W1978602103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25821965" @default.
• W1978602103 hasPublicationYear "2015" @default.
• W1978602103 type Work @default.
• W1978602103 sameAs 1978602103 @default.
• W1978602103 citedByCount "20" @default.
• W1978602103 countsByYear W19786021032015 @default.
• W1978602103 countsByYear W19786021032016 @default.
• W1978602103 countsByYear W19786021032017 @default.
• W1978602103 countsByYear W19786021032018 @default.
• W1978602103 countsByYear W19786021032019 @default.
• W1978602103 countsByYear W19786021032020 @default.
• W1978602103 countsByYear W19786021032021 @default.
• W1978602103 countsByYear W19786021032022 @default.
• W1978602103 countsByYear W19786021032023 @default.
• W1978602103 crossrefType "journal-article" @default.
• W1978602103 hasAuthorship W1978602103A5009811665 @default.
• W1978602103 hasAuthorship W1978602103A5012803702 @default.
• W1978602103 hasAuthorship W1978602103A5021173497 @default.
• W1978602103 hasAuthorship W1978602103A5022141624 @default.
• W1978602103 hasAuthorship W1978602103A5041690571 @default.
• W1978602103 hasAuthorship W1978602103A5047289105 @default.
• W1978602103 hasAuthorship W1978602103A5052871114 @default.
• W1978602103 hasAuthorship W1978602103A5091083080 @default.
• W1978602103 hasBestOaLocation W19786021031 @default.
• W1978602103 hasConcept C104317684 @default.
• W1978602103 hasConcept C135763542 @default.
• W1978602103 hasConcept C156719811 @default.
• W1978602103 hasConcept C159047783 @default.
• W1978602103 hasConcept C194575299 @default.
• W1978602103 hasConcept C2522874641 @default.
• W1978602103 hasConcept C2756471 @default.
• W1978602103 hasConcept C2775940106 @default.
• W1978602103 hasConcept C2777382497 @default.
• W1978602103 hasConcept C2777410769 @default.
• W1978602103 hasConcept C2780593183 @default.
• W1978602103 hasConcept C49105822 @default.
• W1978602103 hasConcept C501734568 @default.
• W1978602103 hasConcept C54355233 @default.
• W1978602103 hasConcept C552990157 @default.
• W1978602103 hasConcept C71924100 @default.
• W1978602103 hasConcept C82381507 @default.

• next