Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978608178> ?p ?o ?g. }
- W1978608178 endingPage "664" @default.
- W1978608178 startingPage "656" @default.
- W1978608178 abstract "The protein kinase mTOR (mammalian target of rapamycin) is a critical regulator of cellular metabolism, growth, and proliferation. These processes contribute to tumor formation, and many cancers are characterized by aberrant activation of mTOR. Although activating mutations in mTOR itself have not been identified, deregulation of upstream components that regulate mTOR are prevalent in cancer. The prototypic mechanism of mTOR regulation in cells is through activation of the PI3K/Akt pathway, but mTOR receives input from multiple signaling pathways. This review will discuss Akt-dependent and -independent mechanisms of mTOR regulation in response to mitogenic signals, as well as its regulation in response to energy and nutrient-sensing pathways. Preclinical and clinical studies have demonstrated that tumors bearing genetic alterations that activate mTOR are sensitive to pharmacologic inhibition of mTOR. Elucidation of novel pathways that regulate mTOR may help identify predictive factors for sensitivity to mTOR inhibitors, and could provide new therapeutic targets for inhibiting the mTOR pathway in cancer. This review will also highlight pharmacologic approaches that inhibit mTOR via activation of the AMP-activated protein kinase (AMPK), an important inhibitor of the mTOR pathway and an emerging target in cancer." @default.
- W1978608178 created "2016-06-24" @default.
- W1978608178 creator A5022984824 @default.
- W1978608178 creator A5063141833 @default.
- W1978608178 date "2009-05-01" @default.
- W1978608178 modified "2023-10-14" @default.
- W1978608178 title "Akt-dependent and -independent mechanisms of mTOR regulation in cancer" @default.
- W1978608178 cites W156748014 @default.
- W1978608178 cites W1619256199 @default.
- W1978608178 cites W1876033686 @default.
- W1978608178 cites W1964353872 @default.
- W1978608178 cites W1968513003 @default.
- W1978608178 cites W1968881729 @default.
- W1978608178 cites W1972558089 @default.
- W1978608178 cites W1979380712 @default.
- W1978608178 cites W1979861893 @default.
- W1978608178 cites W1982085282 @default.
- W1978608178 cites W1982501876 @default.
- W1978608178 cites W1983698019 @default.
- W1978608178 cites W1987670956 @default.
- W1978608178 cites W1990278643 @default.
- W1978608178 cites W1990841830 @default.
- W1978608178 cites W1991386861 @default.
- W1978608178 cites W1992257057 @default.
- W1978608178 cites W1993363796 @default.
- W1978608178 cites W1993655397 @default.
- W1978608178 cites W1995874255 @default.
- W1978608178 cites W1999720438 @default.
- W1978608178 cites W2000697168 @default.
- W1978608178 cites W2001568034 @default.
- W1978608178 cites W2002054992 @default.
- W1978608178 cites W2011282245 @default.
- W1978608178 cites W2011876441 @default.
- W1978608178 cites W2017082986 @default.
- W1978608178 cites W2017996683 @default.
- W1978608178 cites W2018553282 @default.
- W1978608178 cites W2021020436 @default.
- W1978608178 cites W2025176940 @default.
- W1978608178 cites W2026562903 @default.
- W1978608178 cites W2026967508 @default.
- W1978608178 cites W2027442494 @default.
- W1978608178 cites W2029938976 @default.
- W1978608178 cites W2030720692 @default.
- W1978608178 cites W2031918765 @default.
- W1978608178 cites W2033668762 @default.
- W1978608178 cites W2036394201 @default.
- W1978608178 cites W2037177985 @default.
- W1978608178 cites W2038227076 @default.
- W1978608178 cites W2038287200 @default.
- W1978608178 cites W2040662861 @default.
- W1978608178 cites W2041811289 @default.
- W1978608178 cites W2042444876 @default.
- W1978608178 cites W2045627834 @default.
- W1978608178 cites W2050790870 @default.
- W1978608178 cites W2053848504 @default.
- W1978608178 cites W2054683873 @default.
- W1978608178 cites W2054998824 @default.
- W1978608178 cites W2056111473 @default.
- W1978608178 cites W2060611693 @default.
- W1978608178 cites W2061216192 @default.
- W1978608178 cites W2064242629 @default.
- W1978608178 cites W2064656431 @default.
- W1978608178 cites W2065887259 @default.
- W1978608178 cites W2066659565 @default.
- W1978608178 cites W2067710601 @default.
- W1978608178 cites W2067979493 @default.
- W1978608178 cites W2069793811 @default.
- W1978608178 cites W2073067473 @default.
- W1978608178 cites W2074894911 @default.
- W1978608178 cites W2078190084 @default.
- W1978608178 cites W2081920342 @default.
- W1978608178 cites W2082472130 @default.
- W1978608178 cites W2082853003 @default.
- W1978608178 cites W2083390963 @default.
- W1978608178 cites W2085567056 @default.
- W1978608178 cites W2086589626 @default.
- W1978608178 cites W2089609187 @default.
- W1978608178 cites W2093341871 @default.
- W1978608178 cites W2093489637 @default.
- W1978608178 cites W2094719535 @default.
- W1978608178 cites W2094941511 @default.
- W1978608178 cites W2095454212 @default.
- W1978608178 cites W2098947405 @default.
- W1978608178 cites W2101952870 @default.
- W1978608178 cites W2102891343 @default.
- W1978608178 cites W2105561184 @default.
- W1978608178 cites W2108446473 @default.
- W1978608178 cites W2112001957 @default.
- W1978608178 cites W2113288593 @default.
- W1978608178 cites W2113962581 @default.
- W1978608178 cites W2114438728 @default.
- W1978608178 cites W2115820946 @default.
- W1978608178 cites W2116738170 @default.
- W1978608178 cites W2117275311 @default.
- W1978608178 cites W2118719170 @default.
- W1978608178 cites W2120774442 @default.
- W1978608178 cites W2121727754 @default.
- W1978608178 cites W2122649002 @default.