FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978609533> ?p ?o ?g. }

• W1978609533 endingPage "598" @default.
• W1978609533 startingPage "592" @default.
• W1978609533 abstract "Toll-like receptors (TLRs) play an important role in the induction of host responses to pathogens. Interactions between TLRs and their ligands result in the production of cytokines that modulate the adaptive immune response through polarizing CD4+ T cells into either T-helper (TH)1 or TH2 phenotypes. In this regard, TLR2 and TLR5 ligands have been shown to induce responses in mammals that are biased toward TH1 or TH2 phenotypes. However, whether a similar phenomenon occurs in chickens remains to be elucidated. To this end, chicken splenocytes were stimulated with the TLR2 ligand Pam3CSK4 and the TLR5 ligand flagellin, and the relative expression of several cytokines and transcription factors was quantified at 1, 3, 8, and 18 h poststimulation. The results suggest that both TLR ligands induce a mixed TH1- and TH2-like response, as characterized by the upregulation of both the TH1-associated cytokine interferon-γ and the TH1-inducing cytokine interleukin (IL)-12, in addition to the TH2-associated cytokine IL-4, and in the case of flagellin, IL-13 as well. Future studies may be aimed at assessing the adjuvant potential of these ligands." @default.
• W1978609533 created "2016-06-24" @default.
• W1978609533 creator A5053518780 @default.
• W1978609533 creator A5077160641 @default.
• W1978609533 creator A5078145678 @default.
• W1978609533 date "2012-12-01" @default.
• W1978609533 modified "2023-10-06" @default.
• W1978609533 title "Treatment with Ligands for Toll-Like Receptors 2 and 5 Induces a Mixed T-helper 1- and 2-Like Response in Chicken Splenocytes" @default.
• W1978609533 cites W1503037824 @default.
• W1978609533 cites W1850171316 @default.
• W1978609533 cites W1918530663 @default.
• W1978609533 cites W1981562068 @default.
• W1978609533 cites W1985766571 @default.
• W1978609533 cites W1988948587 @default.
• W1978609533 cites W1989757640 @default.
• W1978609533 cites W1996118452 @default.
• W1978609533 cites W2000192473 @default.
• W1978609533 cites W2004773897 @default.
• W1978609533 cites W2009053589 @default.
• W1978609533 cites W2021359036 @default.
• W1978609533 cites W2025056472 @default.
• W1978609533 cites W2029294419 @default.
• W1978609533 cites W2038417097 @default.
• W1978609533 cites W2046791906 @default.
• W1978609533 cites W2057027223 @default.
• W1978609533 cites W2059498834 @default.
• W1978609533 cites W2060693296 @default.
• W1978609533 cites W2070727054 @default.
• W1978609533 cites W2089060011 @default.
• W1978609533 cites W2091398245 @default.
• W1978609533 cites W2093029664 @default.
• W1978609533 cites W2095111536 @default.
• W1978609533 cites W2104533871 @default.
• W1978609533 cites W2104910525 @default.
• W1978609533 cites W2106759463 @default.
• W1978609533 cites W2108244474 @default.
• W1978609533 cites W2126809389 @default.
• W1978609533 cites W2127136381 @default.
• W1978609533 cites W2128181270 @default.
• W1978609533 cites W2129682322 @default.
• W1978609533 cites W2130421043 @default.
• W1978609533 cites W2150927114 @default.
• W1978609533 cites W2151620835 @default.
• W1978609533 cites W2318059699 @default.
• W1978609533 cites W2886978647 @default.
• W1978609533 doi "https://doi.org/10.1089/jir.2012.0004" @default.
• W1978609533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23030671" @default.
• W1978609533 hasPublicationYear "2012" @default.
• W1978609533 type Work @default.
• W1978609533 sameAs 1978609533 @default.
• W1978609533 citedByCount "21" @default.
• W1978609533 countsByYear W19786095332013 @default.
• W1978609533 countsByYear W19786095332014 @default.
• W1978609533 countsByYear W19786095332015 @default.
• W1978609533 countsByYear W19786095332016 @default.
• W1978609533 countsByYear W19786095332017 @default.
• W1978609533 countsByYear W19786095332018 @default.
• W1978609533 countsByYear W19786095332019 @default.
• W1978609533 countsByYear W19786095332020 @default.
• W1978609533 countsByYear W19786095332021 @default.
• W1978609533 crossrefType "journal-article" @default.
• W1978609533 hasAuthorship W1978609533A5053518780 @default.
• W1978609533 hasAuthorship W1978609533A5077160641 @default.
• W1978609533 hasAuthorship W1978609533A5078145678 @default.
• W1978609533 hasConcept C104317684 @default.
• W1978609533 hasConcept C127561419 @default.
• W1978609533 hasConcept C136449434 @default.
• W1978609533 hasConcept C170493617 @default.
• W1978609533 hasConcept C185592680 @default.
• W1978609533 hasConcept C189976730 @default.
• W1978609533 hasConcept C193419808 @default.
• W1978609533 hasConcept C203014093 @default.
• W1978609533 hasConcept C2776709828 @default.
• W1978609533 hasConcept C2777338127 @default.
• W1978609533 hasConcept C2778690821 @default.
• W1978609533 hasConcept C2781236682 @default.
• W1978609533 hasConcept C38117629 @default.
• W1978609533 hasConcept C54355233 @default.
• W1978609533 hasConcept C86803240 @default.
• W1978609533 hasConcept C8891405 @default.
• W1978609533 hasConcept C95444343 @default.
• W1978609533 hasConceptScore W1978609533C104317684 @default.
• W1978609533 hasConceptScore W1978609533C127561419 @default.
• W1978609533 hasConceptScore W1978609533C136449434 @default.
• W1978609533 hasConceptScore W1978609533C170493617 @default.
• W1978609533 hasConceptScore W1978609533C185592680 @default.
• W1978609533 hasConceptScore W1978609533C189976730 @default.
• W1978609533 hasConceptScore W1978609533C193419808 @default.
• W1978609533 hasConceptScore W1978609533C203014093 @default.
• W1978609533 hasConceptScore W1978609533C2776709828 @default.
• W1978609533 hasConceptScore W1978609533C2777338127 @default.
• W1978609533 hasConceptScore W1978609533C2778690821 @default.
• W1978609533 hasConceptScore W1978609533C2781236682 @default.
• W1978609533 hasConceptScore W1978609533C38117629 @default.
• W1978609533 hasConceptScore W1978609533C54355233 @default.
• W1978609533 hasConceptScore W1978609533C86803240 @default.
• W1978609533 hasConceptScore W1978609533C8891405 @default.
• W1978609533 hasConceptScore W1978609533C95444343 @default.

• next