FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978611062> ?p ?o ?g. }

• W1978611062 endingPage "4283" @default.
• W1978611062 startingPage "4266" @default.
• W1978611062 abstract "The B-cell–activating factor (BAFF)-receptor (BAFF-R) is restrictedly expressed on B-cells and is often overexpressed in B-cell malignancies, such as non-Hodgkin’s lymphoma. On binding to its ligand BAFF, proliferation and cell survival are increased, enabling cancer cells to proliferate faster than normal B-cells. Nucleic acid aptamers can bind to target ligands with high specificity and affinity and may offer therapeutic advantages over antibody-based approaches. In this study, we isolated several 2′-F–modified RNA aptamers targeting the B-cell–specific BAFF-R with nanomolar affinity using in vitro SELEX technology. The aptamers efficiently bound to BAFF-R on the surface of B-cells, blocked BAFF-mediated B-cell proliferation and were internalized into B-cells. Furthermore, chimeric molecules between the BAFF-R aptamer and small interfering RNAs (siRNAs) were specifically delivered to BAFF-R expressing cells with a similar efficiency as the aptamer alone. We demonstrate that a signal transducer and activator of transcription 3 (STAT3) siRNA delivered by the BAFF-R aptamer was processed by Dicer and efficiently reduced levels of target mRNA and protein in Jeko-1 and Z138 human B-cell lines. Collectively, our results demonstrate that the dual-functional BAFF-R aptamer–siRNA conjugates are able to deliver siRNAs and block ligand mediated processes, suggesting it might be a promising combinatorial therapeutic agent for B-cell malignancies." @default.
• W1978611062 created "2016-06-24" @default.
• W1978611062 creator A5021999626 @default.
• W1978611062 creator A5026698996 @default.
• W1978611062 creator A5033024988 @default.
• W1978611062 creator A5038048435 @default.
• W1978611062 creator A5039374832 @default.
• W1978611062 creator A5046038634 @default.
• W1978611062 creator A5067271688 @default.
• W1978611062 creator A5075903729 @default.
• W1978611062 creator A5076085956 @default.
• W1978611062 creator A5086999864 @default.
• W1978611062 date "2013-03-06" @default.
• W1978611062 modified "2023-09-23" @default.
• W1978611062 title "Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells" @default.
• W1978611062 cites W1514511317 @default.
• W1978611062 cites W1548640328 @default.
• W1978611062 cites W159302622 @default.
• W1978611062 cites W1625166229 @default.
• W1978611062 cites W1801771134 @default.
• W1978611062 cites W1967663251 @default.
• W1978611062 cites W1974182660 @default.
• W1978611062 cites W1975249184 @default.
• W1978611062 cites W1978302597 @default.
• W1978611062 cites W1989279522 @default.
• W1978611062 cites W1992650640 @default.
• W1978611062 cites W2002961521 @default.
• W1978611062 cites W2009228236 @default.
• W1978611062 cites W2012030976 @default.
• W1978611062 cites W2021930150 @default.
• W1978611062 cites W2021932553 @default.
• W1978611062 cites W2022334475 @default.
• W1978611062 cites W2024282024 @default.
• W1978611062 cites W2026496528 @default.
• W1978611062 cites W2026496740 @default.
• W1978611062 cites W2028555435 @default.
• W1978611062 cites W2043971353 @default.
• W1978611062 cites W2044227662 @default.
• W1978611062 cites W2047994380 @default.
• W1978611062 cites W2058281262 @default.
• W1978611062 cites W2070217465 @default.
• W1978611062 cites W2072646319 @default.
• W1978611062 cites W2074356752 @default.
• W1978611062 cites W2077880964 @default.
• W1978611062 cites W2079321730 @default.
• W1978611062 cites W2079351745 @default.
• W1978611062 cites W2082854624 @default.
• W1978611062 cites W2087378450 @default.
• W1978611062 cites W2090324342 @default.
• W1978611062 cites W2097129513 @default.
• W1978611062 cites W2099001057 @default.
• W1978611062 cites W2105066639 @default.
• W1978611062 cites W2123175900 @default.
• W1978611062 cites W2123525329 @default.
• W1978611062 cites W2127099126 @default.
• W1978611062 cites W2135508499 @default.
• W1978611062 cites W2135668656 @default.
• W1978611062 cites W2135837360 @default.
• W1978611062 cites W2137109655 @default.
• W1978611062 cites W2141729181 @default.
• W1978611062 cites W2142187278 @default.
• W1978611062 cites W2144333395 @default.
• W1978611062 cites W2149147994 @default.
• W1978611062 cites W2150382709 @default.
• W1978611062 cites W2150429309 @default.
• W1978611062 cites W2152330468 @default.
• W1978611062 cites W2156113162 @default.
• W1978611062 cites W2165948908 @default.
• W1978611062 cites W2166397226 @default.
• W1978611062 cites W2167571754 @default.
• W1978611062 cites W2268798119 @default.
• W1978611062 doi "https://doi.org/10.1093/nar/gkt125" @default.
• W1978611062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3627597" @default.
• W1978611062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23470998" @default.
• W1978611062 hasPublicationYear "2013" @default.
• W1978611062 type Work @default.
• W1978611062 sameAs 1978611062 @default.
• W1978611062 citedByCount "67" @default.
• W1978611062 countsByYear W19786110622013 @default.
• W1978611062 countsByYear W19786110622014 @default.
• W1978611062 countsByYear W19786110622015 @default.
• W1978611062 countsByYear W19786110622016 @default.
• W1978611062 countsByYear W19786110622017 @default.
• W1978611062 countsByYear W19786110622018 @default.
• W1978611062 countsByYear W19786110622019 @default.
• W1978611062 countsByYear W19786110622020 @default.
• W1978611062 countsByYear W19786110622021 @default.
• W1978611062 countsByYear W19786110622022 @default.
• W1978611062 countsByYear W19786110622023 @default.
• W1978611062 crossrefType "journal-article" @default.
• W1978611062 hasAuthorship W1978611062A5021999626 @default.
• W1978611062 hasAuthorship W1978611062A5026698996 @default.
• W1978611062 hasAuthorship W1978611062A5033024988 @default.
• W1978611062 hasAuthorship W1978611062A5038048435 @default.
• W1978611062 hasAuthorship W1978611062A5039374832 @default.
• W1978611062 hasAuthorship W1978611062A5046038634 @default.
• W1978611062 hasAuthorship W1978611062A5067271688 @default.
• W1978611062 hasAuthorship W1978611062A5075903729 @default.

• next