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• W1978614486 abstract "A potentiated whole-body startle response was produced in rats by pairing intense acoustic stimuli with a light (conditional stimulus) formerly presented contiguously with electric shock. Administration of the selective serotonin (5-HT) 1A ligand 8-hydroxy-2-(di-n-propylamino)tetralin (0.125 and 0.5 mg/kg) blocked the potentiation of startle induced by the conditional stimulus. 1-[3-Chlorophenyl]piperazine, a non-anxiolytic 5-HT1B/1C agonist, did not block potentiated startle, even at a dose (1.0 mg/kg) that induced significant overall decreases in startle amplitude. The non-benzodiazepine anxiolytics buspirone (1.25-5.0 mg/kg), gepirone (3.0-10.0 mg/kg) and the related 5-HT1A ligand ipsapirone (1.0-10.0 mg/kg) blocked potentiated startle, though effects of the non-selective serotonin antagonist methysergide (0.3-10.0 mg/kg) fell short of significance. These data support a role for the 5-HT1A binding site in the anti-anxiety effects of buspirone and related compounds over a range of behavioral procedures." @default.
• W1978614486 created "2016-06-24" @default.
• W1978614486 creator A5022528712 @default.
• W1978614486 creator A5034576114 @default.
• W1978614486 date "1988-11-01" @default.
• W1978614486 modified "2023-09-26" @default.
• W1978614486 title "Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands" @default.
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• W1978614486 doi "https://doi.org/10.1016/0014-2999(88)90283-x" @default.
• W1978614486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2975225" @default.
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