Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978617813> ?p ?o ?g. }
- W1978617813 endingPage "2095" @default.
- W1978617813 startingPage "2086" @default.
- W1978617813 abstract "Traumatic peripheral nerve lesions can cause local anesthesia, paralysis and loss of autonomic control. Reconstruction using engineered nerve guidance conduits (NGCs) is rarely successful due to the sub-optimal characteristics of the conduits. To address the demands of clinical practice, we developed a hierarchically structured NGC from slowly resorbing poly(3-hydroxybutyric acid) (P3HB). The NGC consists of a permeable single-lumen tube and melt-spun fibrillar lumen fillers. Permeable tubes were constructed from P3HB/poly(ɛ-caprolactone) (PCL) blends or poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) (P(3HB-co-4HB)). Polyvinylpyrrolidone was used as a porogen in solvent-free thermoplastic processing, followed by selective polymer leaching. All tested material compositions showed hydrolytic degradation after 16 weeks in phosphate buffered saline, whereas P3HB/PCL tubes maintained mechanical strength compared to (P(3HB-co-4HB)). The porous scaffolds allowed diffusion of large molecules (∼70 kDa). In vitro studies demonstrated that mouse fibroblasts survived and proliferated inside closed porous tubes. An in vitro model of axonal regeneration using dorsal root ganglia and sympathetic cervical ganglia demonstrated that the NGCs successfully supported neuron survival and neurite outgrowth. The introduction of fibrillar lumen fillers promoted oriented neurite growth and coating with extracellular matrix proteins further increased ganglia attachment and cell migration. In this study we show that P3HB-based NGCs scaffolds have potential in long gap peripheral nerve repair strategies." @default.
- W1978617813 created "2016-06-24" @default.
- W1978617813 creator A5015920322 @default.
- W1978617813 creator A5021364481 @default.
- W1978617813 creator A5026342394 @default.
- W1978617813 creator A5045906157 @default.
- W1978617813 creator A5057628028 @default.
- W1978617813 creator A5069167689 @default.
- W1978617813 creator A5085704504 @default.
- W1978617813 creator A5086247846 @default.
- W1978617813 date "2014-05-01" @default.
- W1978617813 modified "2023-10-16" @default.
- W1978617813 title "Hierarchically structured nerve guidance channels based on poly-3-hydroxybutyrate enhance oriented axonal outgrowth" @default.
- W1978617813 cites W1510977144 @default.
- W1978617813 cites W1516408301 @default.
- W1978617813 cites W1834115420 @default.
- W1978617813 cites W1970436035 @default.
- W1978617813 cites W1974605213 @default.
- W1978617813 cites W1975544542 @default.
- W1978617813 cites W1975551679 @default.
- W1978617813 cites W1977033139 @default.
- W1978617813 cites W1985499103 @default.
- W1978617813 cites W1995712351 @default.
- W1978617813 cites W1999855393 @default.
- W1978617813 cites W2011318299 @default.
- W1978617813 cites W2012758254 @default.
- W1978617813 cites W2014522580 @default.
- W1978617813 cites W2015656249 @default.
- W1978617813 cites W2017351572 @default.
- W1978617813 cites W2019286039 @default.
- W1978617813 cites W2020165673 @default.
- W1978617813 cites W2025223433 @default.
- W1978617813 cites W2026709323 @default.
- W1978617813 cites W2027862144 @default.
- W1978617813 cites W2028895530 @default.
- W1978617813 cites W2030305862 @default.
- W1978617813 cites W2031488295 @default.
- W1978617813 cites W2034809261 @default.
- W1978617813 cites W2039517105 @default.
- W1978617813 cites W2040320961 @default.
- W1978617813 cites W2043016721 @default.
- W1978617813 cites W2046223223 @default.
- W1978617813 cites W2048670135 @default.
- W1978617813 cites W2054410626 @default.
- W1978617813 cites W2056023823 @default.
- W1978617813 cites W2056663971 @default.
- W1978617813 cites W2057968303 @default.
- W1978617813 cites W2062375268 @default.
- W1978617813 cites W2063415024 @default.
- W1978617813 cites W2065617830 @default.
- W1978617813 cites W2069548263 @default.
- W1978617813 cites W2074895254 @default.
- W1978617813 cites W2078497186 @default.
- W1978617813 cites W2081931951 @default.
- W1978617813 cites W2083419195 @default.
- W1978617813 cites W2087257500 @default.
- W1978617813 cites W2089640591 @default.
- W1978617813 cites W2100169867 @default.
- W1978617813 cites W2100390238 @default.
- W1978617813 cites W2106343205 @default.
- W1978617813 cites W2112752680 @default.
- W1978617813 cites W2113919900 @default.
- W1978617813 cites W2128892158 @default.
- W1978617813 cites W2130409399 @default.
- W1978617813 cites W2134956686 @default.
- W1978617813 cites W2138909102 @default.
- W1978617813 cites W2141923577 @default.
- W1978617813 cites W2142254746 @default.
- W1978617813 cites W2146369085 @default.
- W1978617813 cites W2148714283 @default.
- W1978617813 cites W2170086730 @default.
- W1978617813 cites W4211251702 @default.
- W1978617813 cites W4231953041 @default.
- W1978617813 doi "https://doi.org/10.1016/j.actbio.2013.12.053" @default.
- W1978617813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24406197" @default.
- W1978617813 hasPublicationYear "2014" @default.
- W1978617813 type Work @default.
- W1978617813 sameAs 1978617813 @default.
- W1978617813 citedByCount "18" @default.
- W1978617813 countsByYear W19786178132015 @default.
- W1978617813 countsByYear W19786178132016 @default.
- W1978617813 countsByYear W19786178132017 @default.
- W1978617813 countsByYear W19786178132018 @default.
- W1978617813 countsByYear W19786178132020 @default.
- W1978617813 countsByYear W19786178132021 @default.
- W1978617813 countsByYear W19786178132022 @default.
- W1978617813 countsByYear W19786178132023 @default.
- W1978617813 crossrefType "journal-article" @default.
- W1978617813 hasAuthorship W1978617813A5015920322 @default.
- W1978617813 hasAuthorship W1978617813A5021364481 @default.
- W1978617813 hasAuthorship W1978617813A5026342394 @default.
- W1978617813 hasAuthorship W1978617813A5045906157 @default.
- W1978617813 hasAuthorship W1978617813A5057628028 @default.
- W1978617813 hasAuthorship W1978617813A5069167689 @default.
- W1978617813 hasAuthorship W1978617813A5085704504 @default.
- W1978617813 hasAuthorship W1978617813A5086247846 @default.
- W1978617813 hasConcept C113246987 @default.
- W1978617813 hasConcept C12554922 @default.