FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978619006> ?p ?o ?g. }

• W1978619006 endingPage "538" @default.
• W1978619006 startingPage "531" @default.
• W1978619006 abstract "1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] produces an acute stimulation of calcium influx in cultured chick embryo myocytes through activation of voltage-gated Ca2+ channels and involvement of cyclic AMP-dependent protein kinase A (PKA). To investigate the participation of protein kinase C (PKC) in this hormone-induced response, calcium uptake was measured in myocytes treated with PKC activators 12-O-tetradecanoyl phorbol 13-acetate (TPA, 50 nM) or 1,2-dioctanoyl-rac-glycerol (DOG, 50 microM). TPA and DOG decreased 45Ca2+ uptake 37% below control cultures. Contrarily, the PKC inhibitors H7 and staurosporine increase myocyte Ca2+ uptake 51% and 54%, respectively. In addition, PKC activity was augmented in cytosol (39%) and membranes (31%) of myocytes after 5 min of treatment with 0.1 nM 1,25(OH)2D3. Likewise, the hormone induced a fast biphasic formation of diacylglycerol, the natural PKC activator, peaking at 30 s (26%) and 3 min (39%). On the other hand, the stimulation of Ca2+ uptake induced by compound H7 as well as 1,25(OH)2D3 was completely abolished with a specific PKA inhibitor. H7 also produced an increase in cAMP levels (172%) and PKA activity (204%). These results suggest the participation of PKC in 1,25(OH)2D3 regulated calcium influx in heart cells and the operation of a cross-talk mechanism between the PKC and PKA pathways." @default.
• W1978619006 created "2016-06-24" @default.
• W1978619006 creator A5019334331 @default.
• W1978619006 creator A5055150960 @default.
• W1978619006 creator A5062612045 @default.
• W1978619006 date "1994-07-01" @default.
• W1978619006 modified "2023-09-26" @default.
• W1978619006 title "Involvement of protein kinase C in 1,25(OH)2-vitamin D3 regulation of calcium uptake by cultured myocytes" @default.
• W1978619006 cites W1045314443 @default.
• W1978619006 cites W1484232403 @default.
• W1978619006 cites W1508219985 @default.
• W1978619006 cites W1521493025 @default.
• W1978619006 cites W1531695673 @default.
• W1978619006 cites W1571844404 @default.
• W1978619006 cites W1748624304 @default.
• W1978619006 cites W1775749144 @default.
• W1978619006 cites W1854781184 @default.
• W1978619006 cites W194629505 @default.
• W1978619006 cites W1964890334 @default.
• W1978619006 cites W1970356220 @default.
• W1978619006 cites W1973454785 @default.
• W1978619006 cites W1978332275 @default.
• W1978619006 cites W1980854090 @default.
• W1978619006 cites W1987411433 @default.
• W1978619006 cites W1988159250 @default.
• W1978619006 cites W1997290852 @default.
• W1978619006 cites W2008278018 @default.
• W1978619006 cites W2015571904 @default.
• W1978619006 cites W2027047679 @default.
• W1978619006 cites W2049796734 @default.
• W1978619006 cites W2051988300 @default.
• W1978619006 cites W2061628918 @default.
• W1978619006 cites W2064169026 @default.
• W1978619006 cites W2081094274 @default.
• W1978619006 cites W2086203532 @default.
• W1978619006 cites W2108175078 @default.
• W1978619006 cites W2121294572 @default.
• W1978619006 cites W2130557891 @default.
• W1978619006 cites W2140314600 @default.
• W1978619006 cites W2149637850 @default.
• W1978619006 cites W2168526937 @default.
• W1978619006 cites W2417343450 @default.
• W1978619006 doi "https://doi.org/10.1016/0898-6568(94)90007-8" @default.
• W1978619006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7818989" @default.
• W1978619006 hasPublicationYear "1994" @default.
• W1978619006 type Work @default.
• W1978619006 sameAs 1978619006 @default.
• W1978619006 citedByCount "20" @default.
• W1978619006 countsByYear W19786190062015 @default.
• W1978619006 crossrefType "journal-article" @default.
• W1978619006 hasAuthorship W1978619006A5019334331 @default.
• W1978619006 hasAuthorship W1978619006A5055150960 @default.
• W1978619006 hasAuthorship W1978619006A5062612045 @default.
• W1978619006 hasConcept C126322002 @default.
• W1978619006 hasConcept C134018914 @default.
• W1978619006 hasConcept C170493617 @default.
• W1978619006 hasConcept C181199279 @default.
• W1978619006 hasConcept C184235292 @default.
• W1978619006 hasConcept C185592680 @default.
• W1978619006 hasConcept C195794163 @default.
• W1978619006 hasConcept C207200792 @default.
• W1978619006 hasConcept C24998067 @default.
• W1978619006 hasConcept C2777314051 @default.
• W1978619006 hasConcept C2779084600 @default.
• W1978619006 hasConcept C2780043322 @default.
• W1978619006 hasConcept C36020004 @default.
• W1978619006 hasConcept C519063684 @default.
• W1978619006 hasConcept C55493867 @default.
• W1978619006 hasConcept C71924100 @default.
• W1978619006 hasConcept C86803240 @default.
• W1978619006 hasConcept C88045685 @default.
• W1978619006 hasConcept C97029542 @default.
• W1978619006 hasConcept C98539663 @default.
• W1978619006 hasConceptScore W1978619006C126322002 @default.
• W1978619006 hasConceptScore W1978619006C134018914 @default.
• W1978619006 hasConceptScore W1978619006C170493617 @default.
• W1978619006 hasConceptScore W1978619006C181199279 @default.
• W1978619006 hasConceptScore W1978619006C184235292 @default.
• W1978619006 hasConceptScore W1978619006C185592680 @default.
• W1978619006 hasConceptScore W1978619006C195794163 @default.
• W1978619006 hasConceptScore W1978619006C207200792 @default.
• W1978619006 hasConceptScore W1978619006C24998067 @default.
• W1978619006 hasConceptScore W1978619006C2777314051 @default.
• W1978619006 hasConceptScore W1978619006C2779084600 @default.
• W1978619006 hasConceptScore W1978619006C2780043322 @default.
• W1978619006 hasConceptScore W1978619006C36020004 @default.
• W1978619006 hasConceptScore W1978619006C519063684 @default.
• W1978619006 hasConceptScore W1978619006C55493867 @default.
• W1978619006 hasConceptScore W1978619006C71924100 @default.
• W1978619006 hasConceptScore W1978619006C86803240 @default.
• W1978619006 hasConceptScore W1978619006C88045685 @default.
• W1978619006 hasConceptScore W1978619006C97029542 @default.
• W1978619006 hasConceptScore W1978619006C98539663 @default.
• W1978619006 hasIssue "5" @default.
• W1978619006 hasLocation W19786190061 @default.
• W1978619006 hasLocation W19786190062 @default.
• W1978619006 hasOpenAccess W1978619006 @default.
• W1978619006 hasPrimaryLocation W19786190061 @default.

• next