FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978620346> ?p ?o ?g. }

• W1978620346 endingPage "3567" @default.
• W1978620346 startingPage "3563" @default.
• W1978620346 abstract "Loss of heterozygosity at 3p21.3 occurs in more than 90% of small cell lung carcinomas (SCLCs). The Ras association domain family 1 (RASSF1) gene cloned from the lung tumor suppressor locus 3p21.3 consists of two major alternative transcripts, RASSF1A and RASSF1C. Epigenetic inactivation of isoform A (RASSF1A) was observed in 40% of primary non-small cell lung carcinomas and in several tumor cell lines. Transfection of RASSF1A suppressed the growth of lung cancer cells in vitro and in nude mice. Here we have analysed the methylation status of the CpG island promoters of RASSF1A and RASSF1C in primary SCLCs. In 22 of 28 SCLCs (=79%) the promoter of RASSF1A was highly methylated at all CpG sites analysed. None of the SCLCs showed evidence for methylation of the CpG island of RASSF1C. The results suggest that hypermethylation of the CpG island promoter of the RASSF1A gene is associated with SCLC pathogenesis." @default.
• W1978620346 created "2016-06-24" @default.
• W1978620346 creator A5048312997 @default.
• W1978620346 creator A5053104118 @default.
• W1978620346 creator A5090236371 @default.
• W1978620346 date "2001-06-14" @default.
• W1978620346 modified "2023-10-16" @default.
• W1978620346 title "The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas" @default.
• W1978620346 cites W1504197144 @default.
• W1978620346 cites W1512173429 @default.
• W1978620346 cites W1538717269 @default.
• W1978620346 cites W1552528612 @default.
• W1978620346 cites W1556996865 @default.
• W1978620346 cites W1968263601 @default.
• W1978620346 cites W1969229561 @default.
• W1978620346 cites W1977706798 @default.
• W1978620346 cites W2010488494 @default.
• W1978620346 cites W2024109518 @default.
• W1978620346 cites W2027448694 @default.
• W1978620346 cites W2030480699 @default.
• W1978620346 cites W2052333525 @default.
• W1978620346 cites W2054823635 @default.
• W1978620346 cites W2060515359 @default.
• W1978620346 cites W2063110349 @default.
• W1978620346 cites W2067942051 @default.
• W1978620346 cites W2072481802 @default.
• W1978620346 cites W2073038957 @default.
• W1978620346 cites W2085226130 @default.
• W1978620346 cites W2087404852 @default.
• W1978620346 cites W2088706525 @default.
• W1978620346 cites W2091976105 @default.
• W1978620346 cites W2094388972 @default.
• W1978620346 cites W2100475900 @default.
• W1978620346 cites W2110511887 @default.
• W1978620346 cites W2118586965 @default.
• W1978620346 cites W2141916872 @default.
• W1978620346 cites W2168558729 @default.
• W1978620346 cites W2172010722 @default.
• W1978620346 cites W4245466760 @default.
• W1978620346 doi "https://doi.org/10.1038/sj.onc.1204469" @default.
• W1978620346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11429703" @default.
• W1978620346 hasPublicationYear "2001" @default.
• W1978620346 type Work @default.
• W1978620346 sameAs 1978620346 @default.
• W1978620346 citedByCount "175" @default.
• W1978620346 countsByYear W19786203462012 @default.
• W1978620346 countsByYear W19786203462013 @default.
• W1978620346 countsByYear W19786203462014 @default.
• W1978620346 countsByYear W19786203462015 @default.
• W1978620346 countsByYear W19786203462016 @default.
• W1978620346 countsByYear W19786203462017 @default.
• W1978620346 countsByYear W19786203462018 @default.
• W1978620346 countsByYear W19786203462019 @default.
• W1978620346 countsByYear W19786203462020 @default.
• W1978620346 countsByYear W19786203462022 @default.
• W1978620346 countsByYear W19786203462023 @default.
• W1978620346 crossrefType "journal-article" @default.
• W1978620346 hasAuthorship W1978620346A5048312997 @default.
• W1978620346 hasAuthorship W1978620346A5053104118 @default.
• W1978620346 hasAuthorship W1978620346A5090236371 @default.
• W1978620346 hasBestOaLocation W19786203461 @default.
• W1978620346 hasConcept C104317684 @default.
• W1978620346 hasConcept C140173407 @default.
• W1978620346 hasConcept C142724271 @default.
• W1978620346 hasConcept C143589142 @default.
• W1978620346 hasConcept C150194340 @default.
• W1978620346 hasConcept C153911025 @default.
• W1978620346 hasConcept C180754005 @default.
• W1978620346 hasConcept C190727270 @default.
• W1978620346 hasConcept C2776256026 @default.
• W1978620346 hasConcept C2778264664 @default.
• W1978620346 hasConcept C33288867 @default.
• W1978620346 hasConcept C41091548 @default.
• W1978620346 hasConcept C502942594 @default.
• W1978620346 hasConcept C54355233 @default.
• W1978620346 hasConcept C555283112 @default.
• W1978620346 hasConcept C71924100 @default.
• W1978620346 hasConcept C86803240 @default.
• W1978620346 hasConceptScore W1978620346C104317684 @default.
• W1978620346 hasConceptScore W1978620346C140173407 @default.
• W1978620346 hasConceptScore W1978620346C142724271 @default.
• W1978620346 hasConceptScore W1978620346C143589142 @default.
• W1978620346 hasConceptScore W1978620346C150194340 @default.
• W1978620346 hasConceptScore W1978620346C153911025 @default.
• W1978620346 hasConceptScore W1978620346C180754005 @default.
• W1978620346 hasConceptScore W1978620346C190727270 @default.
• W1978620346 hasConceptScore W1978620346C2776256026 @default.
• W1978620346 hasConceptScore W1978620346C2778264664 @default.
• W1978620346 hasConceptScore W1978620346C33288867 @default.
• W1978620346 hasConceptScore W1978620346C41091548 @default.
• W1978620346 hasConceptScore W1978620346C502942594 @default.
• W1978620346 hasConceptScore W1978620346C54355233 @default.
• W1978620346 hasConceptScore W1978620346C555283112 @default.
• W1978620346 hasConceptScore W1978620346C71924100 @default.
• W1978620346 hasConceptScore W1978620346C86803240 @default.
• W1978620346 hasIssue "27" @default.
• W1978620346 hasLocation W19786203461 @default.
• W1978620346 hasLocation W19786203462 @default.

• next