FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978621808> ?p ?o ?g. }

• W1978621808 endingPage "385" @default.
• W1978621808 startingPage "374" @default.
• W1978621808 abstract "Macroautophagy (autophagy herein) is a cellular catabolic mechanism activated in response to stress conditions including starvation, hypoxia and misfolded protein accumulation. Abnormalities in autophagy were associated with pathologies including cancer and neurodegenerative diseases. Hence, elucidation of the signaling pathways controlling autophagy is of utmost importance. Recently we and others described microRNAs (miRNAs) as novel and potent modulators of the autophagic activity. Here, we describe MIR181A (hsa-miR-181a-1) as a new autophagy-regulating miRNA. We showed that overexpression of MIR181A resulted in the attenuation of starvation- and rapamycin-induced autophagy in MCF-7, Huh-7 and K562 cells. Moreover, antagomir-mediated inactivation of endogenous miRNA activity stimulated autophagy. We identified ATG5 as an MIR181A target. Indeed, ATG5 cellular levels were decreased in cells upon MIR181A overexpression and increased following the introduction of antagomirs. More importantly, overexpression of ATG5 from a miRNA-insensitive cDNA construct rescued autophagic activity in the presence of MIR181A. We also showed that the ATG5 3' UTR contained functional MIR181A responsive sequences sensitive to point mutations. Therefore, MIR181A is a novel and important regulator of autophagy and ATG5 is a rate-limiting miRNA target in this effect." @default.
• W1978621808 created "2016-06-24" @default.
• W1978621808 creator A5041160545 @default.
• W1978621808 creator A5070627183 @default.
• W1978621808 creator A5073433535 @default.
• W1978621808 creator A5079323488 @default.
• W1978621808 creator A5089151419 @default.
• W1978621808 date "2013-03-07" @default.
• W1978621808 modified "2023-10-18" @default.
• W1978621808 title "<i><i>MIR181A</i></i>regulates starvation- and rapamycin-induced autophagy through targeting of<i><i>ATG5</i></i>" @default.
• W1978621808 cites W1931182390 @default.
• W1978621808 cites W1955837289 @default.
• W1978621808 cites W1965602034 @default.
• W1978621808 cites W1977767269 @default.
• W1978621808 cites W1982475443 @default.
• W1978621808 cites W1982517035 @default.
• W1978621808 cites W1985124617 @default.
• W1978621808 cites W1988137199 @default.
• W1978621808 cites W1989042684 @default.
• W1978621808 cites W1991944677 @default.
• W1978621808 cites W1995689125 @default.
• W1978621808 cites W2001591494 @default.
• W1978621808 cites W2006535551 @default.
• W1978621808 cites W2006892443 @default.
• W1978621808 cites W2009258758 @default.
• W1978621808 cites W2014205131 @default.
• W1978621808 cites W2014946489 @default.
• W1978621808 cites W2024782183 @default.
• W1978621808 cites W2025310815 @default.
• W1978621808 cites W2029758324 @default.
• W1978621808 cites W2032801961 @default.
• W1978621808 cites W2033228345 @default.
• W1978621808 cites W2033480960 @default.
• W1978621808 cites W2038592957 @default.
• W1978621808 cites W2039564681 @default.
• W1978621808 cites W2040157483 @default.
• W1978621808 cites W2042748226 @default.
• W1978621808 cites W2046250764 @default.
• W1978621808 cites W2051062186 @default.
• W1978621808 cites W2051175862 @default.
• W1978621808 cites W2056274991 @default.
• W1978621808 cites W2058167857 @default.
• W1978621808 cites W2059382687 @default.
• W1978621808 cites W2066027374 @default.
• W1978621808 cites W2066800765 @default.
• W1978621808 cites W2069203180 @default.
• W1978621808 cites W2069938223 @default.
• W1978621808 cites W2081057817 @default.
• W1978621808 cites W2092793317 @default.
• W1978621808 cites W2093637710 @default.
• W1978621808 cites W2100434800 @default.
• W1978621808 cites W2103782088 @default.
• W1978621808 cites W2106125288 @default.
• W1978621808 cites W2115886998 @default.
• W1978621808 cites W2130350123 @default.
• W1978621808 cites W2136754349 @default.
• W1978621808 cites W2136946154 @default.
• W1978621808 cites W2145021085 @default.
• W1978621808 cites W2146124002 @default.
• W1978621808 cites W2150168624 @default.
• W1978621808 cites W2156320420 @default.
• W1978621808 cites W2157320227 @default.
• W1978621808 cites W2158335669 @default.
• W1978621808 cites W2161832345 @default.
• W1978621808 cites W2164778558 @default.
• W1978621808 cites W2165682628 @default.
• W1978621808 doi "https://doi.org/10.4161/auto.23117" @default.
• W1978621808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3590257" @default.
• W1978621808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23322078" @default.
• W1978621808 hasPublicationYear "2013" @default.
• W1978621808 type Work @default.
• W1978621808 sameAs 1978621808 @default.
• W1978621808 citedByCount "149" @default.
• W1978621808 countsByYear W19786218082013 @default.
• W1978621808 countsByYear W19786218082014 @default.
• W1978621808 countsByYear W19786218082015 @default.
• W1978621808 countsByYear W19786218082016 @default.
• W1978621808 countsByYear W19786218082017 @default.
• W1978621808 countsByYear W19786218082018 @default.
• W1978621808 countsByYear W19786218082019 @default.
• W1978621808 countsByYear W19786218082020 @default.
• W1978621808 countsByYear W19786218082021 @default.
• W1978621808 countsByYear W19786218082022 @default.
• W1978621808 countsByYear W19786218082023 @default.
• W1978621808 crossrefType "journal-article" @default.
• W1978621808 hasAuthorship W1978621808A5041160545 @default.
• W1978621808 hasAuthorship W1978621808A5070627183 @default.
• W1978621808 hasAuthorship W1978621808A5073433535 @default.
• W1978621808 hasAuthorship W1978621808A5079323488 @default.
• W1978621808 hasAuthorship W1978621808A5089151419 @default.
• W1978621808 hasBestOaLocation W19786218081 @default.
• W1978621808 hasConcept C104317684 @default.
• W1978621808 hasConcept C145059251 @default.
• W1978621808 hasConcept C190283241 @default.
• W1978621808 hasConcept C203522944 @default.
• W1978621808 hasConcept C2779368916 @default.
• W1978621808 hasConcept C2780329694 @default.
• W1978621808 hasConcept C2781000418 @default.

• next