FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978628059> ?p ?o ?g. }

• W1978628059 endingPage "534" @default.
• W1978628059 startingPage "521" @default.
• W1978628059 abstract "Branching epithelial morphogenesis requires interactions between the surrounding mesenchyme and the epithelium, as well as interactions between basement membrane components and the epithelium. Embryonic submandibular gland was used to study the roles of two mesenchymal proteins, epimorphin and tenascin-C, as well as the epithelial protein laminin-1 and one of its integrin receptors on branching morphogenesis. Laminin-1 is a heterotrimer composed of an alpha 1 chain and two smaller chains (beta 1 and gamma 1). Immunofluorescence revealed a transient expression of laminin alpha 1 chain in the epithelial basement membrane during early stages of branching morphogenesis. Other laminin-1 chains and alpha 6, beta 1, and beta 4 integrin subunits seemed to be expressed constitutively. Expression of epimorphin, but not tenascin-C, was seen in the mesenchyme during early developmental stages, but a mAb against epimorphin did not perturb branching morphogenesis of this early epithelium. In contrast, inhibition of branching morphogenesis was seen with a mAb against the carboxy terminus of laminin alpha 1 chain, the E3 domain. An inhibition of branching was also seen with a mAb against the integrin alpha 6 subunit. The antibodies against laminin alpha 1 chain and integrin alpha 6 subunit perturbed development in distinct fashions. Whereas treatment with the anti-E3 resulted in discontinuities of the basement membrane at the tips of the branching epithelium, treatment with the mAb against alpha 6 integrin subunit seemed to leave the basement membrane intact. We suggest that the laminin E3 domain is involved in basement membrane formation, whereas alpha 6 beta 1 integrin binding to laminin-1 may elicit differentiation signals to the epithelial cells." @default.
• W1978628059 created "2016-06-24" @default.
• W1978628059 creator A5000979295 @default.
• W1978628059 creator A5010869157 @default.
• W1978628059 creator A5019979103 @default.
• W1978628059 creator A5031719922 @default.
• W1978628059 creator A5052786761 @default.
• W1978628059 creator A5063937409 @default.
• W1978628059 date "1995-04-15" @default.
• W1978628059 modified "2023-10-18" @default.
• W1978628059 title "Antibodies against domain E3 of laminin-1 and integrin alpha 6 subunit perturb branching epithelial morphogenesis of submandibular gland, but by different modes." @default.
• W1978628059 cites W1481780101 @default.
• W1978628059 cites W1501642560 @default.
• W1978628059 cites W1503392039 @default.
• W1978628059 cites W1516705869 @default.
• W1978628059 cites W1552674921 @default.
• W1978628059 cites W1556735704 @default.
• W1978628059 cites W1560452279 @default.
• W1978628059 cites W1605235578 @default.
• W1978628059 cites W1832431561 @default.
• W1978628059 cites W1871354819 @default.
• W1978628059 cites W1917323404 @default.
• W1978628059 cites W1933015809 @default.
• W1978628059 cites W1958074989 @default.
• W1978628059 cites W1967338106 @default.
• W1978628059 cites W1967811843 @default.
• W1978628059 cites W1973064020 @default.
• W1978628059 cites W1974342547 @default.
• W1978628059 cites W1976152088 @default.
• W1978628059 cites W1978250825 @default.
• W1978628059 cites W1988297300 @default.
• W1978628059 cites W1988645163 @default.
• W1978628059 cites W1989582506 @default.
• W1978628059 cites W1999578623 @default.
• W1978628059 cites W2008115339 @default.
• W1978628059 cites W2008517901 @default.
• W1978628059 cites W2013771439 @default.
• W1978628059 cites W2014894751 @default.
• W1978628059 cites W2027940697 @default.
• W1978628059 cites W2035015033 @default.
• W1978628059 cites W2036145275 @default.
• W1978628059 cites W2040413836 @default.
• W1978628059 cites W2045447486 @default.
• W1978628059 cites W2050106278 @default.
• W1978628059 cites W2050118331 @default.
• W1978628059 cites W2051811193 @default.
• W1978628059 cites W2051831840 @default.
• W1978628059 cites W2052728159 @default.
• W1978628059 cites W2083260142 @default.
• W1978628059 cites W2083790449 @default.
• W1978628059 cites W2084675705 @default.
• W1978628059 cites W2091288418 @default.
• W1978628059 cites W2091751557 @default.
• W1978628059 cites W2093514870 @default.
• W1978628059 cites W2120465728 @default.
• W1978628059 cites W2123257594 @default.
• W1978628059 cites W2125922025 @default.
• W1978628059 cites W2134812217 @default.
• W1978628059 cites W2143315617 @default.
• W1978628059 cites W2152324425 @default.
• W1978628059 cites W2152550248 @default.
• W1978628059 cites W2155619649 @default.
• W1978628059 cites W2163108176 @default.
• W1978628059 cites W2163614009 @default.
• W1978628059 cites W2165123145 @default.
• W1978628059 cites W2198246212 @default.
• W1978628059 cites W2257257862 @default.
• W1978628059 cites W2289101943 @default.
• W1978628059 cites W4251787522 @default.
• W1978628059 cites W4251805238 @default.
• W1978628059 cites W67419533 @default.
• W1978628059 doi "https://doi.org/10.1083/jcb.129.2.521" @default.
• W1978628059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199919" @default.
• W1978628059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7536749" @default.
• W1978628059 hasPublicationYear "1995" @default.
• W1978628059 type Work @default.
• W1978628059 sameAs 1978628059 @default.
• W1978628059 citedByCount "176" @default.
• W1978628059 countsByYear W19786280592012 @default.
• W1978628059 countsByYear W19786280592013 @default.
• W1978628059 countsByYear W19786280592014 @default.
• W1978628059 countsByYear W19786280592015 @default.
• W1978628059 countsByYear W19786280592016 @default.
• W1978628059 countsByYear W19786280592017 @default.
• W1978628059 countsByYear W19786280592019 @default.
• W1978628059 countsByYear W19786280592020 @default.
• W1978628059 countsByYear W19786280592021 @default.
• W1978628059 countsByYear W19786280592022 @default.
• W1978628059 countsByYear W19786280592023 @default.
• W1978628059 crossrefType "journal-article" @default.
• W1978628059 hasAuthorship W1978628059A5000979295 @default.
• W1978628059 hasAuthorship W1978628059A5010869157 @default.
• W1978628059 hasAuthorship W1978628059A5019979103 @default.
• W1978628059 hasAuthorship W1978628059A5031719922 @default.
• W1978628059 hasAuthorship W1978628059A5052786761 @default.
• W1978628059 hasAuthorship W1978628059A5063937409 @default.
• W1978628059 hasBestOaLocation W19786280591 @default.
• W1978628059 hasConcept C104317684 @default.

• next