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• W1978628204 abstract "The emerging global epidemic of drug-resistant tuberculosis has created an urgent need to identify novel therapeutic approaches for disease treatment. Transvalencin Z (1) is a natural product from Nocardia transvalensis with relatively potent and selective antimycobacterial activity against Mycobacterium smegmatis, making it an attractive target for structure-activity and mechanism of action studies. The total synthesis of the four possible diastereomers of transvalencin Z was completed (1a-d), and the absolute configurations were defined using chemical synthesis, HPLC retention times, and optical rotation measurements. Surprisingly, none of the transvalencin Z diastereomers exhibited any inhibitory activity against a panel of microbial pathogens, including several species of mycobacteria." @default.
• W1978628204 created "2016-06-24" @default.
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• W1978628204 date "2012-05-22" @default.
• W1978628204 modified "2023-10-16" @default.
• W1978628204 title "Total Synthesis and Biological Evaluation of Transvalencin Z" @default.
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• W1978628204 doi "https://doi.org/10.1021/np200972s" @default.
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