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- W1978642692 abstract "OBJECTIVE To investigate, in Senegalese subjects, the frequency of human leukocyte antigen (HLA)-DQβ1 alleles and their role in susceptibility to insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS HLA-DQβ1 typing was done in 55 IDDM subjects and 118 nondiabetic control subjects by means of polymerase chain reaction restriction fragment length polymorphism. RESULTS All;eles bearing a codon for an Asp residue at position 57 in the DQ β-chain were associated with a significantly lower risk of IDDM. Alleles 0201 and 0302 (Ala57) were positively associated with diabetes, but allele 0501 (Val57) was less frequent in IDDM subjects than in control subjects. CONCLUSIONS HLA-DQβl alleles may be genetic susceptibility markers for IDDM in the Senegalese population, as they are in Caucasian populations." @default.
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- W1978642692 date "1995-05-01" @default.
- W1978642692 modified "2023-10-16" @default.
- W1978642692 title "HLA-DQβl Typing and Non-Asp57 Alleles in the Aborigine Population of Senegal" @default.
- W1978642692 doi "https://doi.org/10.2337/diacare.18.5.677" @default.
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