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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978646997> ?p ?o ?g. }

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• W1978646997 abstract "Objective: Determine if aspirin inhibits the IL-1β–stimulated expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and prostaglandin E2 (PGE2) in rat ovarian dispersates cultured in vitro.Design: Prospective, controlled in vitro study.Setting: Academic research laboratory.Animals: Ovaries collected from immature rats.Intervention(s): Ovaries were collected from immature rats and enzymatically dispersed. Ovarian dispersates were placed into plates containing media alone or media supplemented with IL-1β (100 U/mL) and varying concentrations of aspirin (0, 1, 3, 5 and 10 mM). Ovarian dispersates were cultured in a humidified environment of 5% CO2 in air at 37°C for 24 or 48 hours.Main Outcome Measure(s): Twenty-four– and 48-hour iNOS, nitrite (a stable metabolite of NO), and PGE2 levels were determined from ovarian dispersates cultured in vitro.Result(s): Administration of IL-1β increased nitrite and PGE2 levels over that observed in the control group after culture of ovarian dispersates for 24 and 48 hours. Aspirin dose dependently reduced the IL-1β–stimulated increase in nitrite production from ovarian dispersates after culture for 24 and 48 hours. Aspirin completely (24 hours) or dose dependently (48 hours) prevented the IL-β–stimulated increase in PGE2. Coadministration of IL-1β and aspirin (10 mM) attenuates IL-1β–stimulated iNOS expression after culture for 24 and 48 hours.Conclusion(s): Aspirin significantly inhibits the IL-1β–stimulated expression of iNOS, NO, and PGE2 in ovarian dispersates cultured in vitro." @default.
• W1978646997 created "2016-06-24" @default.
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• W1978646997 date "2001-04-01" @default.
• W1978646997 modified "2023-09-27" @default.
• W1978646997 title "Aspirin dose dependently inhibits the interleukin-1β–stimulated increase in inducible nitric oxide synthase, nitric oxide, and prostaglandin E2 production in rat ovarian dispersates cultured in vitro" @default.
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• W1978646997 doi "https://doi.org/10.1016/s0015-0282(00)01784-2" @default.
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