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• W1978650247 abstract "Eighteen symmetrical bis-Schiff base derivatives of isatin were synthesized by condensation of the natural or synthetic isatins with hydrazine and were evaluated for their in vitro and in vivo antitumor activities. More than half of the obtained compounds showed potent cytotoxicity according to the MTT assay on five different human cancer cell lines (i.e. HeLa, SGC-7901, HepG2, U251, and A549), with compound 3b 3,3'-(hydrazine-1,2-diylidene)bis (5-methylindolin-2-one) being the most potent compound on HepG2 (IC₅₀ ∼ 4.23 μM). 3b was also found to be able to inhibit substantially the tumor growth on the HepS-bearing mice at a dose of 40 mg/kg. The real-time live cell imaging and tracking in the H2B-labeled HeLa cells revealed that 3b could induce mitosis interference and apoptosis-associated cell death. In mechanism study, 3b arrested the cell cycle at the G2/M phase in HepG2 cells by down-regulating the expression of cyclin B1 and cdc 2." @default.
• W1978650247 created "2016-06-24" @default.
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• W1978650247 date "2014-03-01" @default.
• W1978650247 modified "2023-10-01" @default.
• W1978650247 title "Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin" @default.
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• W1978650247 doi "https://doi.org/10.1016/j.ejmech.2013.04.040" @default.
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