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- W1978652018 abstract "The neuromuscular response to a reduction of temperature from 34 to 26°C was examined in vitro in the avian biventer cervicis preparation. Cooling over this range potentiated neuromuscular transmission 104% although there was a 35% depression of direct muscle contractility. This potentiation was reduced 53% when the stimulation frequency was increased from 6/min to 24/min, suggesting the involvement of prejunctional processes in the cold response. When the safety margin of neuromuscular transmission was narrowed either prejunctionally with Mg2+ or postjunctionally with d-tubocurarine, cooling potentiated transmission to 127 and 212% respectively. After cholinesterase (ChE) inhibition by eserine the cold potentiation was not observed but this does not indicate that the neuromuscular response to cooling involves substantial inhibition of ChE since the potentiation in muscles treated with both eserine and tubocurarine was restored to within 20% of the response in untreated muscles. Postjuctional sensitivity, which was studied with the tonic response of the muscle to acetylcholine, did not change substancially at 26°C. These results indicate that the potentiation of neuromuscular transmission that occurs with cooling is due primarily to an increased release of neurotransmitter rather than ChE inhibition or an increased postjunctional sensitivity." @default.
- W1978652018 created "2016-06-24" @default.
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- W1978652018 date "1995-01-01" @default.
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- W1978652018 title "The antiarrhythmic preparation search prospectives" @default.
- W1978652018 doi "https://doi.org/10.1016/1043-6618(95)86581-0" @default.
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