FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978652181> ?p ?o ?g. }

• W1978652181 endingPage "2253" @default.
• W1978652181 startingPage "2246" @default.
• W1978652181 abstract "Stability, defined as the reproducible behavior of a device upon its storage, is an important issue in pharmaceutical formulation. Silica xerogels obtained through the sol-gel route are relatively new as matrices for the controlled release of drugs. In some cases, it was observed that their behavior changes upon storage, so that they cannot always be defined as stable. This occurs especially when gel processing is performed at mild temperatures, a procedure that may have to be used to prevent degradation of the embedded drug. This work investigated the use of inorganic catalysts as potential xerogel stability inducers when gel curing by heating is not applicable. Three compounds known to accelerate sol-gel polymerization, namely ammonia, sodium fluoride and sodium carbonate, were introduced during the polymerization of low-temperature processed inorganic and organically modified gels, and the effect of each compound on xerogel stability and drug release was monitored. The use of carbonate leads to formulations with good retention properties, as opposed to ammonia and NaF, which lead to poorly retentive xerogels in accordance with their known ability to increase porosity. Ammonia was shown to be a poor stability promoter independently of gel composition, as opposed to fluoride and carbonate, which both displayed stabilizing properties in a dose-dependent manner. No correlation was found between xerogel stability and drug release properties. An attempt was also made to correlate stability data with polymerization rates and wet gel syneresis time evolution with the purpose of identifying one or more synthesis parameters that could act as stability predictors for pre-formulation studies. No correlation was found between stability and syneresis data. A similar trend in the curve of gel time vs. catalyst concentration was observed for the two stabilizing catalysts, which was different for the non-stabilizing ammonia. It was concluded that the trend of this curve could potentially provide an indicator of catalyst stabilizing efficacy." @default.
• W1978652181 created "2016-06-24" @default.
• W1978652181 creator A5011437836 @default.
• W1978652181 creator A5037539467 @default.
• W1978652181 creator A5046169135 @default.
• W1978652181 creator A5058179279 @default.
• W1978652181 creator A5069582430 @default.
• W1978652181 creator A5087877084 @default.
• W1978652181 date "2010-06-01" @default.
• W1978652181 modified "2023-09-30" @default.
• W1978652181 title "The effect of Na2CO3, NaF and NH4OH on the stability and release behavior of sol–gel derived silica xerogels embedded with bioactive compounds" @default.
• W1978652181 cites W1553515657 @default.
• W1978652181 cites W1970245081 @default.
• W1978652181 cites W1971274804 @default.
• W1978652181 cites W1971618132 @default.
• W1978652181 cites W1976943713 @default.
• W1978652181 cites W1987945823 @default.
• W1978652181 cites W2001118772 @default.
• W1978652181 cites W2001822741 @default.
• W1978652181 cites W2026686449 @default.
• W1978652181 cites W2030777265 @default.
• W1978652181 cites W2031599049 @default.
• W1978652181 cites W2034065624 @default.
• W1978652181 cites W2037325506 @default.
• W1978652181 cites W2038321847 @default.
• W1978652181 cites W2039527959 @default.
• W1978652181 cites W2046287902 @default.
• W1978652181 cites W2052696063 @default.
• W1978652181 cites W2057272751 @default.
• W1978652181 cites W2063466117 @default.
• W1978652181 cites W2081578290 @default.
• W1978652181 cites W2083324577 @default.
• W1978652181 cites W2086130473 @default.
• W1978652181 cites W2086324969 @default.
• W1978652181 cites W2086773063 @default.
• W1978652181 cites W2089352352 @default.
• W1978652181 cites W2093380651 @default.
• W1978652181 cites W2094825003 @default.
• W1978652181 cites W2096096031 @default.
• W1978652181 cites W2142429646 @default.
• W1978652181 cites W46236234 @default.
• W1978652181 doi "https://doi.org/10.1016/j.actbio.2009.12.021" @default.
• W1978652181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20035908" @default.
• W1978652181 hasPublicationYear "2010" @default.
• W1978652181 type Work @default.
• W1978652181 sameAs 1978652181 @default.
• W1978652181 citedByCount "25" @default.
• W1978652181 countsByYear W19786521812012 @default.
• W1978652181 countsByYear W19786521812013 @default.
• W1978652181 countsByYear W19786521812016 @default.
• W1978652181 countsByYear W19786521812017 @default.
• W1978652181 countsByYear W19786521812018 @default.
• W1978652181 countsByYear W19786521812019 @default.
• W1978652181 countsByYear W19786521812020 @default.
• W1978652181 countsByYear W19786521812021 @default.
• W1978652181 countsByYear W19786521812022 @default.
• W1978652181 countsByYear W19786521812023 @default.
• W1978652181 crossrefType "journal-article" @default.
• W1978652181 hasAuthorship W1978652181A5011437836 @default.
• W1978652181 hasAuthorship W1978652181A5037539467 @default.
• W1978652181 hasAuthorship W1978652181A5046169135 @default.
• W1978652181 hasAuthorship W1978652181A5058179279 @default.
• W1978652181 hasAuthorship W1978652181A5069582430 @default.
• W1978652181 hasAuthorship W1978652181A5087877084 @default.
• W1978652181 hasConcept C127413603 @default.
• W1978652181 hasConcept C132976073 @default.
• W1978652181 hasConcept C159985019 @default.
• W1978652181 hasConcept C171250308 @default.
• W1978652181 hasConcept C178790620 @default.
• W1978652181 hasConcept C179104552 @default.
• W1978652181 hasConcept C185592680 @default.
• W1978652181 hasConcept C186399102 @default.
• W1978652181 hasConcept C188027245 @default.
• W1978652181 hasConcept C192562407 @default.
• W1978652181 hasConcept C2779532046 @default.
• W1978652181 hasConcept C2780828025 @default.
• W1978652181 hasConcept C38398224 @default.
• W1978652181 hasConcept C3952536 @default.
• W1978652181 hasConcept C42360764 @default.
• W1978652181 hasConcept C44228677 @default.
• W1978652181 hasConcept C521977710 @default.
• W1978652181 hasConcept C6648577 @default.
• W1978652181 hasConceptScore W1978652181C127413603 @default.
• W1978652181 hasConceptScore W1978652181C132976073 @default.
• W1978652181 hasConceptScore W1978652181C159985019 @default.
• W1978652181 hasConceptScore W1978652181C171250308 @default.
• W1978652181 hasConceptScore W1978652181C178790620 @default.
• W1978652181 hasConceptScore W1978652181C179104552 @default.
• W1978652181 hasConceptScore W1978652181C185592680 @default.
• W1978652181 hasConceptScore W1978652181C186399102 @default.
• W1978652181 hasConceptScore W1978652181C188027245 @default.
• W1978652181 hasConceptScore W1978652181C192562407 @default.
• W1978652181 hasConceptScore W1978652181C2779532046 @default.
• W1978652181 hasConceptScore W1978652181C2780828025 @default.
• W1978652181 hasConceptScore W1978652181C38398224 @default.
• W1978652181 hasConceptScore W1978652181C3952536 @default.
• W1978652181 hasConceptScore W1978652181C42360764 @default.
• W1978652181 hasConceptScore W1978652181C44228677 @default.

• next