Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978652308> ?p ?o ?g. }
- W1978652308 endingPage "282" @default.
- W1978652308 startingPage "274" @default.
- W1978652308 abstract "Objective Parenteral nutrition associated liver disease (PNALD) is a deadly complication of long term parenteral nutrition (PN) use in infants. Fish oil-based lipid emulsion has been shown in recent years to effectively treat PNALD. Alternative fat sources free of essential fatty acids have recently been investigated for health benefits related to decreased inflammatory response. We hypothesized that the addition of medium-chain triglycerides (MCT) to a purified fish oil-based diet would decrease the response to inflammatory challenge in mice, while allowing for sufficient growth and development. Materials/methods Six groups of ten adult male C57/Bl6 mice were pair-fed different dietary treatments for a period of twelve weeks, varying only in fat source (percent calories by weight): 10.84% soybean oil (SOY), 10% coconut oil (HCO), 10% medium-chain triglycerides (MCT), 3% purified fish oil (PFO), 3% purified fish oil with 3% medium-chain triglycerides (50:50 MCT:PFO) and 3% purified fish oil with 7.59% medium-chain triglycerides (70:30 MCT:PFO). An endotoxin challenge was administered to half of the animals in each group at the completion of dietary treatment. Results All groups demonstrated normal growth throughout the study period. Groups fed MCT and HCO diets demonstrated biochemical essential fatty acid deficiency and decreased IL-6 and TNF-α response to endotoxin challenge. Groups containing PFO had increased inflammatory response to endotoxin challenge, and the addition of MCT to PFO mitigated this inflammatory response. Conclusion These results suggest that the addition of MCT to PFO formulations may decrease the host response to inflammatory challenge, which may pose potential for optimized PN formulations. Inclusion of MCT in lipid emulsions given with PN formulations may be of use in therapeutic interventions for disease states resulting from chronic inflammation." @default.
- W1978652308 created "2016-06-24" @default.
- W1978652308 creator A5009775070 @default.
- W1978652308 creator A5021115386 @default.
- W1978652308 creator A5028998864 @default.
- W1978652308 creator A5036335734 @default.
- W1978652308 creator A5048671795 @default.
- W1978652308 creator A5055110028 @default.
- W1978652308 creator A5062540776 @default.
- W1978652308 creator A5066699772 @default.
- W1978652308 creator A5069700498 @default.
- W1978652308 creator A5091882388 @default.
- W1978652308 date "2015-02-01" @default.
- W1978652308 modified "2023-10-18" @default.
- W1978652308 title "The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice" @default.
- W1978652308 cites W1490628486 @default.
- W1978652308 cites W1519842447 @default.
- W1978652308 cites W156046135 @default.
- W1978652308 cites W1956927897 @default.
- W1978652308 cites W1968261228 @default.
- W1978652308 cites W1973944606 @default.
- W1978652308 cites W1975214980 @default.
- W1978652308 cites W2007992392 @default.
- W1978652308 cites W2048294244 @default.
- W1978652308 cites W2054141651 @default.
- W1978652308 cites W2062141358 @default.
- W1978652308 cites W2066545864 @default.
- W1978652308 cites W2074603347 @default.
- W1978652308 cites W2077554022 @default.
- W1978652308 cites W2077945628 @default.
- W1978652308 cites W2078225770 @default.
- W1978652308 cites W2082162513 @default.
- W1978652308 cites W2086673116 @default.
- W1978652308 cites W2094226946 @default.
- W1978652308 cites W2094372895 @default.
- W1978652308 cites W2095063306 @default.
- W1978652308 cites W2099190538 @default.
- W1978652308 cites W2106454717 @default.
- W1978652308 cites W2113630410 @default.
- W1978652308 cites W2120564666 @default.
- W1978652308 cites W2137476159 @default.
- W1978652308 cites W2139635218 @default.
- W1978652308 cites W2149860264 @default.
- W1978652308 cites W2150229187 @default.
- W1978652308 cites W2154472085 @default.
- W1978652308 cites W2156500813 @default.
- W1978652308 cites W2157782662 @default.
- W1978652308 cites W2165911612 @default.
- W1978652308 cites W2168526937 @default.
- W1978652308 cites W2327515496 @default.
- W1978652308 cites W2350871976 @default.
- W1978652308 doi "https://doi.org/10.1016/j.metabol.2014.10.005" @default.
- W1978652308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4277814" @default.
- W1978652308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25458829" @default.
- W1978652308 hasPublicationYear "2015" @default.
- W1978652308 type Work @default.
- W1978652308 sameAs 1978652308 @default.
- W1978652308 citedByCount "37" @default.
- W1978652308 countsByYear W19786523082015 @default.
- W1978652308 countsByYear W19786523082016 @default.
- W1978652308 countsByYear W19786523082017 @default.
- W1978652308 countsByYear W19786523082018 @default.
- W1978652308 countsByYear W19786523082019 @default.
- W1978652308 countsByYear W19786523082020 @default.
- W1978652308 countsByYear W19786523082021 @default.
- W1978652308 countsByYear W19786523082022 @default.
- W1978652308 countsByYear W19786523082023 @default.
- W1978652308 crossrefType "journal-article" @default.
- W1978652308 hasAuthorship W1978652308A5009775070 @default.
- W1978652308 hasAuthorship W1978652308A5021115386 @default.
- W1978652308 hasAuthorship W1978652308A5028998864 @default.
- W1978652308 hasAuthorship W1978652308A5036335734 @default.
- W1978652308 hasAuthorship W1978652308A5048671795 @default.
- W1978652308 hasAuthorship W1978652308A5055110028 @default.
- W1978652308 hasAuthorship W1978652308A5062540776 @default.
- W1978652308 hasAuthorship W1978652308A5066699772 @default.
- W1978652308 hasAuthorship W1978652308A5069700498 @default.
- W1978652308 hasAuthorship W1978652308A5091882388 @default.
- W1978652308 hasBestOaLocation W19786523082 @default.
- W1978652308 hasConcept C126322002 @default.
- W1978652308 hasConcept C134018914 @default.
- W1978652308 hasConcept C185592680 @default.
- W1978652308 hasConcept C2777996180 @default.
- W1978652308 hasConcept C2779885280 @default.
- W1978652308 hasConcept C2779946292 @default.
- W1978652308 hasConcept C2909208804 @default.
- W1978652308 hasConcept C31903555 @default.
- W1978652308 hasConcept C40438245 @default.
- W1978652308 hasConcept C505870484 @default.
- W1978652308 hasConcept C55493867 @default.
- W1978652308 hasConcept C71924100 @default.
- W1978652308 hasConcept C78722104 @default.
- W1978652308 hasConcept C86803240 @default.
- W1978652308 hasConceptScore W1978652308C126322002 @default.
- W1978652308 hasConceptScore W1978652308C134018914 @default.
- W1978652308 hasConceptScore W1978652308C185592680 @default.
- W1978652308 hasConceptScore W1978652308C2777996180 @default.
- W1978652308 hasConceptScore W1978652308C2779885280 @default.