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- W1978654570 abstract "WE investigated the role of melatonin in the induction of gastric lesions induced by water immersion restraint stress or centrally administered thyrotropin-releasing hormone (TRH). Melatonin (0.1–1 ng) injected intracisternally (i.c.) 30 min prior to stress dose-dependently inhibited the induction of gastric lesions by water immersion restraint stress, while 100 μg/kg, i.p. failed to protect the gastric mucosa. Preadministration of melatonin (1 ng, i.c.) significantly reduced (83%) the severity of gastric lesions induced by a TRH analogue (500 ng, i.c.). Serum melatonin concentrations 30 min after administration of 1 ng melatonin i.c. did not differ from those of rats receiving i.c. vehicle. These results suggest that melatonin plays a protective, anti-stress, role in the gastric mucosa via a mechanism involving the central nervous system." @default.
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- W1978654570 date "1997-07-01" @default.
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- W1978654570 title "Central effect of melatonin against stress-induced gastric ulcers in rats" @default.
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- W1978654570 doi "https://doi.org/10.1097/00001756-199707070-00041" @default.
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