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- W1978657412 abstract "The septohippocampal pathway, which is mostly composed of cholinergic and GABAergic projections between the medial septum/diagonal band (MS/DB) and the hippocampus, has an established role in learning, memory and disorders of cognition. In Wernicke-Korsakoff's syndrome (WKS) and the animal model of the disorder, pyrithiamine-induced thiamine deficiency (PTD), there is both diencephalic damage and basal forebrain cell loss that could contribute to the amnesic state. In the current experiment, we used the PTD animal model to access both cholinergic (choline acetyltransferase [ChAT] immunopositive) and GABAergic (parvalbumin [PV]; calbindin [CaBP]) neuronal loss in the MS/DB in relationship to midline-thalamic pathology. In addition, to gain an understanding about the role of such neuropathology in behavioral dysfunction, animals were tested on a non-rewarded spontaneous alternation task and behavioral performance was correlated to neuropathology. Unbiased stereological assessment of neuronal populations revealed that ChAT-positive neurons were significantly reduced in PTD rats, relative to control pair-fed rats, and thalamic mass and behavioral performance correlated with ChAT neuronal estimates. In contrast, both the PV- and CaBP-positive neurons in the MS/DB were not affected by PTD treatment. These results support an interactive role of both thalamic pathology and cholinergic cell loss in diencephalic amnesia." @default.
- W1978657412 created "2016-06-24" @default.
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- W1978657412 date "2009-04-01" @default.
- W1978657412 modified "2023-09-27" @default.
- W1978657412 title "The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia" @default.
- W1978657412 cites W1673416974 @default.
- W1978657412 cites W1930427841 @default.
- W1978657412 cites W1964640629 @default.
- W1978657412 cites W1971796351 @default.
- W1978657412 cites W1973755495 @default.
- W1978657412 cites W1974271370 @default.
- W1978657412 cites W1975657249 @default.
- W1978657412 cites W1976865584 @default.
- W1978657412 cites W1977951194 @default.
- W1978657412 cites W1979686107 @default.
- W1978657412 cites W1982179824 @default.
- W1978657412 cites W1985068308 @default.
- W1978657412 cites W1986306838 @default.
- W1978657412 cites W1987273190 @default.
- W1978657412 cites W1987299183 @default.
- W1978657412 cites W1990073151 @default.
- W1978657412 cites W1990683357 @default.
- W1978657412 cites W1997014753 @default.
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- W1978657412 cites W2000352386 @default.
- W1978657412 cites W2000533565 @default.
- W1978657412 cites W2001497249 @default.
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- W1978657412 cites W2009598439 @default.
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- W1978657412 cites W2041158284 @default.
- W1978657412 cites W2044610087 @default.
- W1978657412 cites W2045683730 @default.
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- W1978657412 doi "https://doi.org/10.1016/j.neuroscience.2009.02.044" @default.
- W1978657412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2899313" @default.
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