FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978657539> ?p ?o ?g. }

• W1978657539 endingPage "41380" @default.
• W1978657539 startingPage "41368" @default.
• W1978657539 abstract "Reversible phosphorylation is the key mechanism regulating several cellular events in prokaryotes and eukaryotes. In prokaryotes, signal transduction is perceived to occur primarily via the two-component signaling system involving histidine kinases and cognate response regulators. Although an alternative regulatory pathway controlled by the eukaryote-type serine/threonine kinase (Streptococcus pyogenes serine/threonine kinase; SP-STK) has been shown to modulate bacterial growth, division, adherence, invasion, and virulence in group A Streptococcus (GAS; S. pyogenes), the precise role of the co-transcribing serine/threonine phosphatase (SP-STP) has remained enigmatic. In this context, this is the first report describing the construction and characterization of non-polar SP-STP mutants in two different strains of Type M1 GAS. The STP knock-out mutants displayed increased bacterial chain lengths in conjunction with thickened cell walls, significantly reduced capsule and hemolysin production, and restoration of the phenotypes postcomplementation. The present study also reveals important contribution of cognately regulated-reversible phosphorylation by SP-STK/SP-STP on two major response regulators of two-component systems, WalRK and CovRS. We also demonstrate a distinct role of SP-STP in terms of expression of surface proteins and SpeB in a strain-specific manner. Further, the attenuation of virulence in the absence of STP and its restoration only in the complemented strains that were generated by the use of a low copy plasmid and not by a high copy one emphasize not only the essential role of STP in virulence but also highlight the tightly regulated SP-STP/SP-STK-mediated cognate functions. SP-STP thus is an important regulator of GAS virulence and plays a critical role in GAS pathogenesis. Reversible phosphorylation is the key mechanism regulating several cellular events in prokaryotes and eukaryotes. In prokaryotes, signal transduction is perceived to occur primarily via the two-component signaling system involving histidine kinases and cognate response regulators. Although an alternative regulatory pathway controlled by the eukaryote-type serine/threonine kinase (Streptococcus pyogenes serine/threonine kinase; SP-STK) has been shown to modulate bacterial growth, division, adherence, invasion, and virulence in group A Streptococcus (GAS; S. pyogenes), the precise role of the co-transcribing serine/threonine phosphatase (SP-STP) has remained enigmatic. In this context, this is the first report describing the construction and characterization of non-polar SP-STP mutants in two different strains of Type M1 GAS. The STP knock-out mutants displayed increased bacterial chain lengths in conjunction with thickened cell walls, significantly reduced capsule and hemolysin production, and restoration of the phenotypes postcomplementation. The present study also reveals important contribution of cognately regulated-reversible phosphorylation by SP-STK/SP-STP on two major response regulators of two-component systems, WalRK and CovRS. We also demonstrate a distinct role of SP-STP in terms of expression of surface proteins and SpeB in a strain-specific manner. Further, the attenuation of virulence in the absence of STP and its restoration only in the complemented strains that were generated by the use of a low copy plasmid and not by a high copy one emphasize not only the essential role of STP in virulence but also highlight the tightly regulated SP-STP/SP-STK-mediated cognate functions. SP-STP thus is an important regulator of GAS virulence and plays a critical role in GAS pathogenesis." @default.
• W1978657539 created "2016-06-24" @default.
• W1978657539 creator A5032124093 @default.
• W1978657539 creator A5064704450 @default.
• W1978657539 creator A5068888294 @default.
• W1978657539 creator A5073753827 @default.
• W1978657539 date "2011-12-01" @default.
• W1978657539 modified "2023-10-16" @default.
• W1978657539 title "Role of Serine/Threonine Phosphatase (SP-STP) in Streptococcus pyogenes Physiology and Virulence" @default.
• W1978657539 cites W1492306356 @default.
• W1978657539 cites W1525202882 @default.
• W1978657539 cites W1906659774 @default.
• W1978657539 cites W1945320323 @default.
• W1978657539 cites W1964697420 @default.
• W1978657539 cites W1968136212 @default.
• W1978657539 cites W1985186068 @default.
• W1978657539 cites W2001129735 @default.
• W1978657539 cites W2004457291 @default.
• W1978657539 cites W2013457323 @default.
• W1978657539 cites W2015068088 @default.
• W1978657539 cites W2024083213 @default.
• W1978657539 cites W2034162042 @default.
• W1978657539 cites W2037294901 @default.
• W1978657539 cites W2056868096 @default.
• W1978657539 cites W2058656568 @default.
• W1978657539 cites W2071229999 @default.
• W1978657539 cites W2073228865 @default.
• W1978657539 cites W2076389746 @default.
• W1978657539 cites W2079630246 @default.
• W1978657539 cites W2080207956 @default.
• W1978657539 cites W2086208676 @default.
• W1978657539 cites W2086337952 @default.
• W1978657539 cites W2097783322 @default.
• W1978657539 cites W2104249152 @default.
• W1978657539 cites W2108559568 @default.
• W1978657539 cites W2111804766 @default.
• W1978657539 cites W2113238027 @default.
• W1978657539 cites W2118580227 @default.
• W1978657539 cites W2120900330 @default.
• W1978657539 cites W2127058468 @default.
• W1978657539 cites W2127326181 @default.
• W1978657539 cites W2127359880 @default.
• W1978657539 cites W2131191824 @default.
• W1978657539 cites W2133491210 @default.
• W1978657539 cites W2136936386 @default.
• W1978657539 cites W2143456788 @default.
• W1978657539 cites W2145619440 @default.
• W1978657539 cites W2147203214 @default.
• W1978657539 cites W2148197405 @default.
• W1978657539 cites W2150541721 @default.
• W1978657539 cites W2155397502 @default.
• W1978657539 cites W2163896955 @default.
• W1978657539 cites W2164859426 @default.
• W1978657539 cites W2165885624 @default.
• W1978657539 cites W2166796891 @default.
• W1978657539 cites W2169171816 @default.
• W1978657539 cites W2171780167 @default.
• W1978657539 doi "https://doi.org/10.1074/jbc.m111.286690" @default.
• W1978657539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3308849" @default.
• W1978657539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21917918" @default.
• W1978657539 hasPublicationYear "2011" @default.
• W1978657539 type Work @default.
• W1978657539 sameAs 1978657539 @default.
• W1978657539 citedByCount "43" @default.
• W1978657539 countsByYear W19786575392012 @default.
• W1978657539 countsByYear W19786575392013 @default.
• W1978657539 countsByYear W19786575392014 @default.
• W1978657539 countsByYear W19786575392015 @default.
• W1978657539 countsByYear W19786575392016 @default.
• W1978657539 countsByYear W19786575392017 @default.
• W1978657539 countsByYear W19786575392018 @default.
• W1978657539 countsByYear W19786575392019 @default.
• W1978657539 countsByYear W19786575392020 @default.
• W1978657539 countsByYear W19786575392021 @default.
• W1978657539 countsByYear W19786575392022 @default.
• W1978657539 countsByYear W19786575392023 @default.
• W1978657539 crossrefType "journal-article" @default.
• W1978657539 hasAuthorship W1978657539A5032124093 @default.
• W1978657539 hasAuthorship W1978657539A5064704450 @default.
• W1978657539 hasAuthorship W1978657539A5068888294 @default.
• W1978657539 hasAuthorship W1978657539A5073753827 @default.
• W1978657539 hasBestOaLocation W19786575391 @default.
• W1978657539 hasConcept C104317684 @default.
• W1978657539 hasConcept C11960822 @default.
• W1978657539 hasConcept C138223613 @default.
• W1978657539 hasConcept C143065580 @default.
• W1978657539 hasConcept C178666793 @default.
• W1978657539 hasConcept C184235292 @default.
• W1978657539 hasConcept C2775880066 @default.
• W1978657539 hasConcept C2776414213 @default.
• W1978657539 hasConcept C2778905257 @default.
• W1978657539 hasConcept C2779306812 @default.
• W1978657539 hasConcept C2779489039 @default.
• W1978657539 hasConcept C2781196521 @default.
• W1978657539 hasConcept C2910050888 @default.
• W1978657539 hasConcept C523546767 @default.
• W1978657539 hasConcept C54355233 @default.
• W1978657539 hasConcept C55493867 @default.

• next