Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978659128> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1978659128 endingPage "322" @default.
- W1978659128 startingPage "317" @default.
- W1978659128 abstract "BackgroundHepatitis C virus (HCV) has been found to infect peripheral blood mononuclear cells (PBMCs), using them as a reservoir, which might contribute to the development of resistance to treatment.ObjectivesTo study hepatitis virus C (HCV) RNA in peripheral blood mononuclear cells (PBMCs) of patients with chronic HCV infection, and explore the relationship between the HCV RNA in the PBMCs and response to interferon (IFN) therapy.MethodsTwenty-five patients with chronic viral hepatitis C were included. The HCV RNA in PBMCs and serum was detected after 12 weeks of initializing interferon treatment, at the end of treatment, and 24 week and 1 year follow up after the end of the treatment. At the end of the treatment course, patients who were found to have positive PCR test for HCV RNA in PBMCs were subdivided into two groups, one group continues to receive IFN therapy while the other group stops. The HCV RNA in PBMCs and serum was detected by RT-PCR using the Amplicor HCV 2.0 assay.ResultsAll patients had negative serum PCR test for HCV RNA at the end of treatment, nevertheless HCV RNA was detected in PBMCs of approximately 32% of these patients. Patients who tested positively for HCV RNA in PBMCs at the end of treatment had an overall significantly higher relapse rate (50%) when compared with patients who tested negatively for HCV RNA in both serum and PBMCs at the end of treatment (6%). Patients with positive HCV RNA in their PBMCs who continue to receive interferon based treatment for further six months had a lower relapse rate (25%) when compared with similar patients who stopped interferon treatment at the 48th week (75%).ConclusionDetection of HCV RNA in PBMCs may be important to assess the virological response to interferon treatment and to predict relapse after antiviral therapy and may be taken as a reference to formulate the duration of antiviral therapy in chronic hepatitis C." @default.
- W1978659128 created "2016-06-24" @default.
- W1978659128 creator A5027318731 @default.
- W1978659128 creator A5031527461 @default.
- W1978659128 creator A5043558078 @default.
- W1978659128 creator A5080797663 @default.
- W1978659128 date "2014-12-01" @default.
- W1978659128 modified "2023-10-17" @default.
- W1978659128 title "HCV RNA in peripheral blood mononuclear cells (PBMCs) as a predictor of the response to antiviral therapy in chronic hepatitis C" @default.
- W1978659128 cites W1571328011 @default.
- W1978659128 cites W166209735 @default.
- W1978659128 cites W183409258 @default.
- W1978659128 cites W1979368286 @default.
- W1978659128 cites W2004197577 @default.
- W1978659128 cites W2005692869 @default.
- W1978659128 cites W2018964760 @default.
- W1978659128 cites W2026067734 @default.
- W1978659128 cites W2026642996 @default.
- W1978659128 cites W2039937486 @default.
- W1978659128 cites W2068466356 @default.
- W1978659128 cites W2080913154 @default.
- W1978659128 cites W2081108572 @default.
- W1978659128 cites W2084821388 @default.
- W1978659128 cites W2110493572 @default.
- W1978659128 cites W2130281450 @default.
- W1978659128 cites W2133180980 @default.
- W1978659128 cites W2138790733 @default.
- W1978659128 cites W2148500203 @default.
- W1978659128 doi "https://doi.org/10.1016/j.ajme.2013.05.004" @default.
- W1978659128 hasPublicationYear "2014" @default.
- W1978659128 type Work @default.
- W1978659128 sameAs 1978659128 @default.
- W1978659128 citedByCount "15" @default.
- W1978659128 countsByYear W19786591282013 @default.
- W1978659128 countsByYear W19786591282014 @default.
- W1978659128 countsByYear W19786591282015 @default.
- W1978659128 countsByYear W19786591282017 @default.
- W1978659128 countsByYear W19786591282019 @default.
- W1978659128 countsByYear W19786591282020 @default.
- W1978659128 countsByYear W19786591282021 @default.
- W1978659128 countsByYear W19786591282023 @default.
- W1978659128 crossrefType "journal-article" @default.
- W1978659128 hasAuthorship W1978659128A5027318731 @default.
- W1978659128 hasAuthorship W1978659128A5031527461 @default.
- W1978659128 hasAuthorship W1978659128A5043558078 @default.
- W1978659128 hasAuthorship W1978659128A5080797663 @default.
- W1978659128 hasBestOaLocation W19786591281 @default.
- W1978659128 hasConcept C104317684 @default.
- W1978659128 hasConcept C137061746 @default.
- W1978659128 hasConcept C159047783 @default.
- W1978659128 hasConcept C202751555 @default.
- W1978659128 hasConcept C203014093 @default.
- W1978659128 hasConcept C2522874641 @default.
- W1978659128 hasConcept C2776178377 @default.
- W1978659128 hasConcept C2776408679 @default.
- W1978659128 hasConcept C2776455275 @default.
- W1978659128 hasConcept C55493867 @default.
- W1978659128 hasConcept C67705224 @default.
- W1978659128 hasConcept C71924100 @default.
- W1978659128 hasConcept C86803240 @default.
- W1978659128 hasConceptScore W1978659128C104317684 @default.
- W1978659128 hasConceptScore W1978659128C137061746 @default.
- W1978659128 hasConceptScore W1978659128C159047783 @default.
- W1978659128 hasConceptScore W1978659128C202751555 @default.
- W1978659128 hasConceptScore W1978659128C203014093 @default.
- W1978659128 hasConceptScore W1978659128C2522874641 @default.
- W1978659128 hasConceptScore W1978659128C2776178377 @default.
- W1978659128 hasConceptScore W1978659128C2776408679 @default.
- W1978659128 hasConceptScore W1978659128C2776455275 @default.
- W1978659128 hasConceptScore W1978659128C55493867 @default.
- W1978659128 hasConceptScore W1978659128C67705224 @default.
- W1978659128 hasConceptScore W1978659128C71924100 @default.
- W1978659128 hasConceptScore W1978659128C86803240 @default.
- W1978659128 hasIssue "4" @default.
- W1978659128 hasLocation W19786591281 @default.
- W1978659128 hasOpenAccess W1978659128 @default.
- W1978659128 hasPrimaryLocation W19786591281 @default.
- W1978659128 hasRelatedWork W138162733 @default.
- W1978659128 hasRelatedWork W1480474081 @default.
- W1978659128 hasRelatedWork W1568848974 @default.
- W1978659128 hasRelatedWork W183409258 @default.
- W1978659128 hasRelatedWork W1977257888 @default.
- W1978659128 hasRelatedWork W2126152546 @default.
- W1978659128 hasRelatedWork W2136046700 @default.
- W1978659128 hasRelatedWork W2142935324 @default.
- W1978659128 hasRelatedWork W2390094673 @default.
- W1978659128 hasRelatedWork W4239232108 @default.
- W1978659128 hasVolume "50" @default.
- W1978659128 isParatext "false" @default.
- W1978659128 isRetracted "false" @default.
- W1978659128 magId "1978659128" @default.
- W1978659128 workType "article" @default.