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- W1978662854 startingPage "e74281" @default.
- W1978662854 abstract "The accepted model for the interaction of α and β integrins in the transmembrane (TM) domain is based on the pair αIIbβ3. This involves the so-called outer and inner membrane association clasps (OMC and IMC, respectively). In the α chain, the OMC involves a GxxxG-like motif, whereas in the IMC a conserved juxtamembrane GFFKR motif experiences a backbone reversal that partially fills the void generated by TM separation towards the cytoplasmic half. However, the GFFKR motif of several α integrin cytoplasmic tails in non-bicelle environments has been shown to adopt an α-helical structure that is not membrane-embedded and which was shown to bind a variety of cytoplasmic proteins. Thus it is not known if a membrane-embedded backbone reversal is a conserved structural feature in α integrins. We have studied the system αLβ2 because of its importance in leukocytes, where integrin deactivation is particularly important. Herein we show that the backbone reversal feature is not only present in αIIb but also in αL-TM when reconstituted in bicelles. Additionally, titration with β2 TM showed eight residues clustering along one side of αL-TM, forming a plausible interacting face with β2. The latter orientation is consistent with a previously predicted reported polar interaction between αL Ser-1071 and β2 Thr-686." @default.
- W1978662854 created "2016-06-24" @default.
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- W1978662854 date "2013-09-12" @default.
- W1978662854 modified "2023-10-17" @default.
- W1978662854 title "Transmembrane and Juxtamembrane Structure of αL Integrin in Bicelles" @default.
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- W1978662854 doi "https://doi.org/10.1371/journal.pone.0074281" @default.
- W1978662854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3771934" @default.
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