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- W1978663882 endingPage "547" @default.
- W1978663882 startingPage "540" @default.
- W1978663882 abstract "•Innate cells contribute to the development of asthma features. •Epithelial cell–DC crosstalk is crucial for asthma development. •Epithelium-derived cytokines contribute to ILC2 responses. •Basophils have no role in Th2 sensitization to HDM, but contribute to the effector phase. Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity. Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity." @default.
- W1978663882 created "2016-06-24" @default.
- W1978663882 creator A5014740733 @default.
- W1978663882 creator A5029130256 @default.
- W1978663882 creator A5068602194 @default.
- W1978663882 date "2013-11-01" @default.
- W1978663882 modified "2023-10-18" @default.
- W1978663882 title "Innate immune cells in asthma" @default.
- W1978663882 cites W1494282279 @default.
- W1978663882 cites W1500518582 @default.
- W1978663882 cites W1536729766 @default.
- W1978663882 cites W1600922886 @default.
- W1978663882 cites W1618095628 @default.
- W1978663882 cites W180174320 @default.
- W1978663882 cites W1824031276 @default.
- W1978663882 cites W1929917332 @default.
- W1978663882 cites W1970152214 @default.
- W1978663882 cites W1971811060 @default.
- W1978663882 cites W1972288125 @default.
- W1978663882 cites W1973651197 @default.
- W1978663882 cites W1973753526 @default.
- W1978663882 cites W1975075371 @default.
- W1978663882 cites W1975184461 @default.
- W1978663882 cites W1982386486 @default.
- W1978663882 cites W1987044793 @default.
- W1978663882 cites W1987699155 @default.
- W1978663882 cites W1988758075 @default.
- W1978663882 cites W1990121282 @default.
- W1978663882 cites W1994569436 @default.
- W1978663882 cites W1997745506 @default.
- W1978663882 cites W1998846885 @default.
- W1978663882 cites W1999705022 @default.
- W1978663882 cites W2000088222 @default.
- W1978663882 cites W2001266086 @default.
- W1978663882 cites W2006304925 @default.
- W1978663882 cites W2006744847 @default.
- W1978663882 cites W2014191094 @default.
- W1978663882 cites W2016030444 @default.
- W1978663882 cites W2017761371 @default.
- W1978663882 cites W2019710737 @default.
- W1978663882 cites W2019815618 @default.
- W1978663882 cites W2023091898 @default.
- W1978663882 cites W2023364946 @default.
- W1978663882 cites W2027462139 @default.
- W1978663882 cites W2027746633 @default.
- W1978663882 cites W2030003617 @default.
- W1978663882 cites W2030904598 @default.
- W1978663882 cites W2032052491 @default.
- W1978663882 cites W2032405768 @default.
- W1978663882 cites W2033289727 @default.
- W1978663882 cites W2038011147 @default.
- W1978663882 cites W2039252747 @default.
- W1978663882 cites W2043546340 @default.
- W1978663882 cites W2043619617 @default.
- W1978663882 cites W2044579357 @default.
- W1978663882 cites W2047882259 @default.
- W1978663882 cites W2050604953 @default.
- W1978663882 cites W2053397734 @default.
- W1978663882 cites W2055937035 @default.
- W1978663882 cites W2062783549 @default.
- W1978663882 cites W2062828989 @default.
- W1978663882 cites W2062918919 @default.
- W1978663882 cites W2068366354 @default.
- W1978663882 cites W2071517396 @default.
- W1978663882 cites W2081535071 @default.
- W1978663882 cites W2081595143 @default.
- W1978663882 cites W2081703815 @default.
- W1978663882 cites W2081940646 @default.
- W1978663882 cites W2088661593 @default.
- W1978663882 cites W2088685932 @default.
- W1978663882 cites W2089685608 @default.
- W1978663882 cites W2090668566 @default.
- W1978663882 cites W2092520647 @default.
- W1978663882 cites W2093268042 @default.
- W1978663882 cites W2101035994 @default.
- W1978663882 cites W2101664092 @default.
- W1978663882 cites W2102930679 @default.
- W1978663882 cites W2103153413 @default.
- W1978663882 cites W2106790228 @default.
- W1978663882 cites W2107195505 @default.
- W1978663882 cites W2109843249 @default.
- W1978663882 cites W2109958057 @default.
- W1978663882 cites W2112580075 @default.
- W1978663882 cites W2112715813 @default.
- W1978663882 cites W2112748508 @default.
- W1978663882 cites W2117787000 @default.
- W1978663882 cites W2117905696 @default.
- W1978663882 cites W2120492641 @default.
- W1978663882 cites W2121686426 @default.
- W1978663882 cites W2121730825 @default.
- W1978663882 cites W2121853472 @default.
- W1978663882 cites W2129235766 @default.
- W1978663882 cites W2132247162 @default.
- W1978663882 cites W2134345359 @default.
- W1978663882 cites W2135525156 @default.
- W1978663882 cites W2136861118 @default.
- W1978663882 cites W2139419077 @default.
- W1978663882 cites W2139901384 @default.