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• W1978676853 abstract "Wnt proteins have been implicated in regulating growth and pattern formation in a variety of tissues during embryonic development. We previously identified Frzb-1, a gene which encodes a secreted protein with homology in the ligand binding domain to the Wnt receptor Frizzled, but lacking the domain encoding the putative seven transmembrane segments. Frzb-1 has recently been shown to bind to Wnt proteins in vitro, and to inhibit the activity of Xenopus Wnt-8 in vivo. We report now that mFrzb-1 and Wnt transcripts display both complementary and overlapping expression patterns at multiple sites throughout embryonic development. By Northern analysis, the expression of mFrzb-1 in the developing mouse embryo is greatest from 10.5 to 12.5 days postcoitum (dpc). In the early embryo, mFrzb-1 is expressed in the primitive streak, presomitic mesoderm, somites, and brain. Later, mFrzb-1 exhibits sharp boundaries of expression in the limb bud, branchial arches, facial mesenchyme, and in cartilaginous elements of the appendicular skeleton. We conclude from these experiments that Frzb-1 is expressed at a time and location to modulate the action of Wnt family members during development of the limbs and central nervous system." @default.
• W1978676853 created "2016-06-24" @default.
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• W1978676853 date "1998-07-01" @default.
• W1978676853 modified "2023-10-03" @default.
• W1978676853 title "Expression pattern of twoFrizzled-related genes,Frzb-1 andSfrp-1, during mouse embryogenesis suggests a role for modulating action ofWnt family members" @default.
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• W1978676853 doi "https://doi.org/10.1002/(sici)1097-0177(199807)212:3<364::aid-aja4>3.0.co;2-f" @default.
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