FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978676885> ?p ?o ?g. }

• W1978676885 endingPage "771" @default.
• W1978676885 startingPage "763" @default.
• W1978676885 abstract "Hydrodynamic-based gene delivery has emerged as an efficient and simple method for the intracellular transfection of naked plasmid DNA (pDNA) in vivo. In this system, a hydrodynamic injection via the tail vein is the most effective non-viral method of liver-targeted gene delivery. However, this injection is often technically challenging when used in animals whose tail veins are difficult to visualize or too small to operate on. To overcome this limitation, an alternative in vivo gene delivery method, the rapid injection of large volume of pDNA solution through retro-orbital sinus, was established. Using this technique, we successfully delivered pDNA to the tissue of adult mice, neonatal mice and tree shrews. The efficient expression of exogenous genes was specifically detected in the liver of test animals treated with this gene delivery method. This study demonstrates for the first time that the hydrodynamic gene delivery via the retro-orbital sinus can not only reach the same transgene efficiency as a tradition hydrodynamic-based intravascular injection but also be used in animals that are difficult to inject via the tail vein. This method could open up new areas in gene function studies and gene therapy disease treatment." @default.
• W1978676885 created "2016-06-24" @default.
• W1978676885 creator A5001920170 @default.
• W1978676885 creator A5002147242 @default.
• W1978676885 creator A5014318730 @default.
• W1978676885 creator A5019886822 @default.
• W1978676885 creator A5040034158 @default.
• W1978676885 creator A5040624036 @default.
• W1978676885 creator A5041448180 @default.
• W1978676885 creator A5045364810 @default.
• W1978676885 creator A5046609605 @default.
• W1978676885 creator A5059402212 @default.
• W1978676885 creator A5068355536 @default.
• W1978676885 creator A5068464222 @default.
• W1978676885 creator A5078093055 @default.
• W1978676885 creator A5078246846 @default.
• W1978676885 date "2012-08-01" @default.
• W1978676885 modified "2023-10-16" @default.
• W1978676885 title "High levels of gene expression in the hepatocytes of adult mice, neonatal mice and tree shrews via retro-orbital sinus hydrodynamic injections of naked plasmid DNA" @default.
• W1978676885 cites W1966622959 @default.
• W1978676885 cites W1978244369 @default.
• W1978676885 cites W1983335647 @default.
• W1978676885 cites W1986655312 @default.
• W1978676885 cites W1988379532 @default.
• W1978676885 cites W1989747647 @default.
• W1978676885 cites W1994160689 @default.
• W1978676885 cites W1994657650 @default.
• W1978676885 cites W2002276220 @default.
• W1978676885 cites W2005599815 @default.
• W1978676885 cites W2006297683 @default.
• W1978676885 cites W2011960130 @default.
• W1978676885 cites W2012063763 @default.
• W1978676885 cites W2020194276 @default.
• W1978676885 cites W2025073354 @default.
• W1978676885 cites W2026743110 @default.
• W1978676885 cites W2031782096 @default.
• W1978676885 cites W2034629713 @default.
• W1978676885 cites W2035574373 @default.
• W1978676885 cites W2045675872 @default.
• W1978676885 cites W2053893513 @default.
• W1978676885 cites W2063957497 @default.
• W1978676885 cites W2066761745 @default.
• W1978676885 cites W2070159291 @default.
• W1978676885 cites W2072069652 @default.
• W1978676885 cites W2075545024 @default.
• W1978676885 cites W2083162782 @default.
• W1978676885 cites W2087289488 @default.
• W1978676885 cites W2097260296 @default.
• W1978676885 cites W2120144890 @default.
• W1978676885 cites W2137660425 @default.
• W1978676885 cites W2140528724 @default.
• W1978676885 cites W2142214679 @default.
• W1978676885 cites W2148300725 @default.
• W1978676885 cites W2149621195 @default.
• W1978676885 cites W2161078046 @default.
• W1978676885 cites W2172293798 @default.
• W1978676885 cites W2172643117 @default.
• W1978676885 cites W2320147764 @default.
• W1978676885 cites W4211072988 @default.
• W1978676885 doi "https://doi.org/10.1016/j.jconrel.2012.05.018" @default.
• W1978676885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22609275" @default.
• W1978676885 hasPublicationYear "2012" @default.
• W1978676885 type Work @default.
• W1978676885 sameAs 1978676885 @default.
• W1978676885 citedByCount "21" @default.
• W1978676885 countsByYear W19786768852013 @default.
• W1978676885 countsByYear W19786768852014 @default.
• W1978676885 countsByYear W19786768852015 @default.
• W1978676885 countsByYear W19786768852016 @default.
• W1978676885 countsByYear W19786768852018 @default.
• W1978676885 countsByYear W19786768852019 @default.
• W1978676885 countsByYear W19786768852020 @default.
• W1978676885 countsByYear W19786768852021 @default.
• W1978676885 countsByYear W19786768852023 @default.
• W1978676885 crossrefType "journal-article" @default.
• W1978676885 hasAuthorship W1978676885A5001920170 @default.
• W1978676885 hasAuthorship W1978676885A5002147242 @default.
• W1978676885 hasAuthorship W1978676885A5014318730 @default.
• W1978676885 hasAuthorship W1978676885A5019886822 @default.
• W1978676885 hasAuthorship W1978676885A5040034158 @default.
• W1978676885 hasAuthorship W1978676885A5040624036 @default.
• W1978676885 hasAuthorship W1978676885A5041448180 @default.
• W1978676885 hasAuthorship W1978676885A5045364810 @default.
• W1978676885 hasAuthorship W1978676885A5046609605 @default.
• W1978676885 hasAuthorship W1978676885A5059402212 @default.
• W1978676885 hasAuthorship W1978676885A5068355536 @default.
• W1978676885 hasAuthorship W1978676885A5068464222 @default.
• W1978676885 hasAuthorship W1978676885A5078093055 @default.
• W1978676885 hasAuthorship W1978676885A5078246846 @default.
• W1978676885 hasConcept C102230213 @default.
• W1978676885 hasConcept C104317684 @default.
• W1978676885 hasConcept C111599444 @default.
• W1978676885 hasConcept C135983454 @default.
• W1978676885 hasConcept C150194340 @default.
• W1978676885 hasConcept C153911025 @default.
• W1978676885 hasConcept C195856716 @default.
• W1978676885 hasConcept C207001950 @default.
• W1978676885 hasConcept C22744801 @default.

• next