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• W1978676887 abstract "High-dose bisphosphonate treatment has been associated with the development of bisphosphonate related osteonecrosis of the jaw (BRONJ) in patients undergoing dental surgery. Burr, Allen, and collaborators 1 Allen M.R. Burr D.B. Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment. J Oral Maxillofac Surg. 2008; 66: 987-994 Abstract Full Text Full Text PDF PubMed Scopus (167) Google Scholar , 2 Allen M.R. Kubek D.J. Burr D.B. et al. Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs. Osteoporos Int. 2011; 22: 693-702 Crossref PubMed Scopus (50) Google Scholar have used a beagle model to study this association. The purpose of this study is to determine what effect recombinant human bone morphogenic protein 2 (rhBMP2) has on the early healing of tooth extraction sites after treatment with a single high dose of zoledronic acid. Nine adult female beagle dogs (2-3 years old) were placed in 3 groups of 3 dogs each. Group I, serving as a control, received 15 ml of sterile saline IV; Group II received 2.5 mg of zoledronic acid IV; Group III received 5 mg of zoledronic acid IV. Forty-five days after treatment, all dogs had both the right and left mandibular first molar and second premolar extracted. In group I the right side extraction sites received were allowed to heal without interference, while the left side sites had absorbable collagen sponge (ACS) placed in them. In groups II and III the right side sites received rhBMP2 carried by ACS and the left side sites received only ACS. All extraction sites were then surgically closed. Fifteen days after extraction and placement of materials in the extraction sites, all animals were euthanized. The right and left mandibles containing the extraction sites were harvested and processed for microscopic analysis. All extraction sites in all groups showed some initial infilling with woven bone. In group I the right side showed woven bone in the apical region that did not fully span the extraction defect. On the left side 25% less woven bone by volume was observed. No significant differences were seen between Groups II and III when the right sides and left sides were grouped. However, the right side in both groups showed significantly more bone infill than the left side. The rhBMP2 treated sites also showed more bone infill than either of the controls with or without ACS. These results indicate that rhBMP2 may enhance early bone infilling in tooth extraction sites in animals that have been treated with high dose bisphosphonates. Additionally, the presence of ACS alone may inhibit early bone infill in tooth extraction sites. At this time there is no evidence of BRONJ. Study supported by Medtronic, Inc." @default.
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• W1978676887 date "2012-09-01" @default.
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• W1978676887 title "Poster 64: Early Effects Of rhBMP2 on Tooth Extraction Sites in Dogs Treated With High-Dose Bisphosphonates" @default.
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• W1978676887 doi "https://doi.org/10.1016/j.joms.2012.06.120" @default.
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