Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978677391> ?p ?o ?g. }
- W1978677391 endingPage "38" @default.
- W1978677391 startingPage "30" @default.
- W1978677391 abstract "A thrombin (EC 3.4.21.5) inhibitor (americanin) was isolated from the salivary glands of the lone star tickAmblyomma americanum(L.) using reversed-phase chromatography and anion-exchange chromatography. Americanin did not inhibit any other protease tested, including factor Xa, plasmin, trypsin, chymotrypsin, elastase, papain, pepsin, and carboxypeptidase. The inhibition of thrombin by americanin decreased dramatically with dilution of the reaction mixture including thrombin, its substrate, and americanin. When thrombin assays were performed in the presence of americanin, the reaction curve showed a time-dependent inhibition. Significant inhibition was observed when americanin concentration was approximately equal to that of thrombin, with aKiof 0.073 nM.The results suggest that americanin is a specific, reversible, competitive, slow, tight-binding inhibitor of thrombin." @default.
- W1978677391 created "2016-06-24" @default.
- W1978677391 creator A5024159022 @default.
- W1978677391 creator A5029171809 @default.
- W1978677391 creator A5061968496 @default.
- W1978677391 creator A5062245437 @default.
- W1978677391 creator A5071871086 @default.
- W1978677391 creator A5091076108 @default.
- W1978677391 date "1997-09-01" @default.
- W1978677391 modified "2023-09-26" @default.
- W1978677391 title "Isolation and Characterization of Americanin, a Specific Inhibitor of Thrombin, from the Salivary Glands of the Lone Star TickAmblyomma americanum(L.)" @default.
- W1978677391 cites W1549037565 @default.
- W1978677391 cites W1565826778 @default.
- W1978677391 cites W1584647394 @default.
- W1978677391 cites W1601949152 @default.
- W1978677391 cites W1965113328 @default.
- W1978677391 cites W1973073456 @default.
- W1978677391 cites W1974320640 @default.
- W1978677391 cites W1975085160 @default.
- W1978677391 cites W1979876532 @default.
- W1978677391 cites W1981522711 @default.
- W1978677391 cites W1982720409 @default.
- W1978677391 cites W1988074091 @default.
- W1978677391 cites W1993649866 @default.
- W1978677391 cites W1994499822 @default.
- W1978677391 cites W2013547341 @default.
- W1978677391 cites W2021569695 @default.
- W1978677391 cites W2034561959 @default.
- W1978677391 cites W2042020109 @default.
- W1978677391 cites W2046644157 @default.
- W1978677391 cites W2046734093 @default.
- W1978677391 cites W2053025020 @default.
- W1978677391 cites W2064567549 @default.
- W1978677391 cites W2070897155 @default.
- W1978677391 cites W2075319601 @default.
- W1978677391 cites W2081983308 @default.
- W1978677391 cites W2095497883 @default.
- W1978677391 cites W2100837269 @default.
- W1978677391 cites W2158136983 @default.
- W1978677391 cites W2208300207 @default.
- W1978677391 cites W2323401394 @default.
- W1978677391 cites W2413885635 @default.
- W1978677391 cites W4293247451 @default.
- W1978677391 doi "https://doi.org/10.1006/expr.1997.4175" @default.
- W1978677391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9287955" @default.
- W1978677391 hasPublicationYear "1997" @default.
- W1978677391 type Work @default.
- W1978677391 sameAs 1978677391 @default.
- W1978677391 citedByCount "56" @default.
- W1978677391 countsByYear W19786773912012 @default.
- W1978677391 countsByYear W19786773912013 @default.
- W1978677391 countsByYear W19786773912014 @default.
- W1978677391 countsByYear W19786773912015 @default.
- W1978677391 countsByYear W19786773912016 @default.
- W1978677391 countsByYear W19786773912017 @default.
- W1978677391 countsByYear W19786773912018 @default.
- W1978677391 countsByYear W19786773912019 @default.
- W1978677391 countsByYear W19786773912020 @default.
- W1978677391 countsByYear W19786773912021 @default.
- W1978677391 countsByYear W19786773912022 @default.
- W1978677391 countsByYear W19786773912023 @default.
- W1978677391 crossrefType "journal-article" @default.
- W1978677391 hasAuthorship W1978677391A5024159022 @default.
- W1978677391 hasAuthorship W1978677391A5029171809 @default.
- W1978677391 hasAuthorship W1978677391A5061968496 @default.
- W1978677391 hasAuthorship W1978677391A5062245437 @default.
- W1978677391 hasAuthorship W1978677391A5071871086 @default.
- W1978677391 hasAuthorship W1978677391A5091076108 @default.
- W1978677391 hasConcept C141814087 @default.
- W1978677391 hasConcept C153911025 @default.
- W1978677391 hasConcept C181199279 @default.
- W1978677391 hasConcept C203014093 @default.
- W1978677391 hasConcept C2776326425 @default.
- W1978677391 hasConcept C2776714187 @default.
- W1978677391 hasConcept C2777292125 @default.
- W1978677391 hasConcept C2778401398 @default.
- W1978677391 hasConcept C2779832904 @default.
- W1978677391 hasConcept C2780340462 @default.
- W1978677391 hasConcept C2781044401 @default.
- W1978677391 hasConcept C2781071845 @default.
- W1978677391 hasConcept C55493867 @default.
- W1978677391 hasConcept C86803240 @default.
- W1978677391 hasConcept C89560881 @default.
- W1978677391 hasConceptScore W1978677391C141814087 @default.
- W1978677391 hasConceptScore W1978677391C153911025 @default.
- W1978677391 hasConceptScore W1978677391C181199279 @default.
- W1978677391 hasConceptScore W1978677391C203014093 @default.
- W1978677391 hasConceptScore W1978677391C2776326425 @default.
- W1978677391 hasConceptScore W1978677391C2776714187 @default.
- W1978677391 hasConceptScore W1978677391C2777292125 @default.
- W1978677391 hasConceptScore W1978677391C2778401398 @default.
- W1978677391 hasConceptScore W1978677391C2779832904 @default.
- W1978677391 hasConceptScore W1978677391C2780340462 @default.
- W1978677391 hasConceptScore W1978677391C2781044401 @default.
- W1978677391 hasConceptScore W1978677391C2781071845 @default.
- W1978677391 hasConceptScore W1978677391C55493867 @default.
- W1978677391 hasConceptScore W1978677391C86803240 @default.
- W1978677391 hasConceptScore W1978677391C89560881 @default.