FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978677669> ?p ?o ?g. }

• W1978677669 endingPage "419" @default.
• W1978677669 startingPage "419" @default.
• W1978677669 abstract "We report a systematic investigation of the mechanical properties of fibroblast cells using a novel cell monolayer rheology (CMR) technique. The new technique provides quantitative rheological parameters averaged over ~106 cells making the experiments highly reproducible. Using this method, we are able to explore a broad range of cell responses not accessible using other present day techniques. We perform harmonic oscillation experiments and step shear or step stress experiments to reveal different viscoelastic regimes. The evolution of the live cells under externally imposed cyclic loading and unloading is also studied. Remarkably, the initially nonlinear response becomes linear at long timescales as well as at large amplitudes. Within the explored rates, nonlinear behaviour is only revealed by the effect of a nonzero average stress on the response to small, fast deformations. When the cell cytoskeletal crosslinks are made permanent using a fixing agent, the large amplitude linear response disappears and the cells exhibit a stress stiffening response instead. This result shows that the dynamic nature of the cross-links and/or filaments is responsible for the linear stress-strain response seen under large deformations. We rule out the involvement of myosin motors in this using the inhibitor drug blebbistatin. These experiments provide a broad framework for understanding the mechanical responses of the cortical actin cytoskeleton of fibroblasts to different imposed mechanical stimuli." @default.
• W1978677669 created "2016-06-24" @default.
• W1978677669 creator A5041706284 @default.
• W1978677669 creator A5042618944 @default.
• W1978677669 creator A5048953315 @default.
• W1978677669 creator A5051477079 @default.
• W1978677669 creator A5063897822 @default.
• W1978677669 date "2007-11-30" @default.
• W1978677669 modified "2023-10-13" @default.
• W1978677669 title "Shear rheology of a cell monolayer" @default.
• W1978677669 cites W1503721880 @default.
• W1978677669 cites W1964195356 @default.
• W1978677669 cites W1971281736 @default.
• W1978677669 cites W1978533003 @default.
• W1978677669 cites W1980056833 @default.
• W1978677669 cites W1984653721 @default.
• W1978677669 cites W1991971871 @default.
• W1978677669 cites W2002208582 @default.
• W1978677669 cites W2009582775 @default.
• W1978677669 cites W2024878957 @default.
• W1978677669 cites W2031459560 @default.
• W1978677669 cites W2035629093 @default.
• W1978677669 cites W2046695461 @default.
• W1978677669 cites W2053890171 @default.
• W1978677669 cites W2060094993 @default.
• W1978677669 cites W2078002094 @default.
• W1978677669 cites W2087729945 @default.
• W1978677669 cites W2095264815 @default.
• W1978677669 cites W2119261959 @default.
• W1978677669 cites W2126531317 @default.
• W1978677669 cites W2128193911 @default.
• W1978677669 cites W2130851152 @default.
• W1978677669 cites W2144007430 @default.
• W1978677669 cites W2144815200 @default.
• W1978677669 cites W2166443752 @default.
• W1978677669 cites W2169413646 @default.
• W1978677669 cites W2171305977 @default.
• W1978677669 cites W2171581053 @default.
• W1978677669 cites W2187901199 @default.
• W1978677669 cites W2217619640 @default.
• W1978677669 cites W2225943435 @default.
• W1978677669 cites W4205490020 @default.
• W1978677669 cites W4212934859 @default.
• W1978677669 cites W942177296 @default.
• W1978677669 doi "https://doi.org/10.1088/1367-2630/9/11/419" @default.
• W1978677669 hasPublicationYear "2007" @default.
• W1978677669 type Work @default.
• W1978677669 sameAs 1978677669 @default.
• W1978677669 citedByCount "67" @default.
• W1978677669 countsByYear W19786776692012 @default.
• W1978677669 countsByYear W19786776692013 @default.
• W1978677669 countsByYear W19786776692014 @default.
• W1978677669 countsByYear W19786776692015 @default.
• W1978677669 countsByYear W19786776692016 @default.
• W1978677669 countsByYear W19786776692017 @default.
• W1978677669 countsByYear W19786776692018 @default.
• W1978677669 countsByYear W19786776692019 @default.
• W1978677669 countsByYear W19786776692021 @default.
• W1978677669 countsByYear W19786776692022 @default.
• W1978677669 countsByYear W19786776692023 @default.
• W1978677669 crossrefType "journal-article" @default.
• W1978677669 hasAuthorship W1978677669A5041706284 @default.
• W1978677669 hasAuthorship W1978677669A5042618944 @default.
• W1978677669 hasAuthorship W1978677669A5048953315 @default.
• W1978677669 hasAuthorship W1978677669A5051477079 @default.
• W1978677669 hasAuthorship W1978677669A5063897822 @default.
• W1978677669 hasBestOaLocation W19786776691 @default.
• W1978677669 hasConcept C121332964 @default.
• W1978677669 hasConcept C159985019 @default.
• W1978677669 hasConcept C171250308 @default.
• W1978677669 hasConcept C192562407 @default.
• W1978677669 hasConcept C200990466 @default.
• W1978677669 hasConcept C57879066 @default.
• W1978677669 hasConcept C7070889 @default.
• W1978677669 hasConcept C96035792 @default.
• W1978677669 hasConcept C97355855 @default.
• W1978677669 hasConceptScore W1978677669C121332964 @default.
• W1978677669 hasConceptScore W1978677669C159985019 @default.
• W1978677669 hasConceptScore W1978677669C171250308 @default.
• W1978677669 hasConceptScore W1978677669C192562407 @default.
• W1978677669 hasConceptScore W1978677669C200990466 @default.
• W1978677669 hasConceptScore W1978677669C57879066 @default.
• W1978677669 hasConceptScore W1978677669C7070889 @default.
• W1978677669 hasConceptScore W1978677669C96035792 @default.
• W1978677669 hasConceptScore W1978677669C97355855 @default.
• W1978677669 hasIssue "11" @default.
• W1978677669 hasLocation W19786776691 @default.
• W1978677669 hasOpenAccess W1978677669 @default.
• W1978677669 hasPrimaryLocation W19786776691 @default.
• W1978677669 hasRelatedWork W103834327 @default.
• W1978677669 hasRelatedWork W1971178477 @default.
• W1978677669 hasRelatedWork W1992361463 @default.
• W1978677669 hasRelatedWork W2044060458 @default.
• W1978677669 hasRelatedWork W2082592332 @default.
• W1978677669 hasRelatedWork W2232485754 @default.
• W1978677669 hasRelatedWork W2611716377 @default.
• W1978677669 hasRelatedWork W3016902089 @default.
• W1978677669 hasRelatedWork W4307072275 @default.

• next