FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978679154> ?p ?o ?g. }

• W1978679154 endingPage "1423" @default.
• W1978679154 startingPage "1414" @default.
• W1978679154 abstract "Polysaccharide peptide (PSP), isolated from COV-1 strain of Coriolus versicolor, is commonly used as an adjunct in cancer chemotherapy in China. In this study, the effects of whole PSP extract and water extract of PSP on 4-hydroxylation of tolbutamide were investigated in rat liver microsomes in vitro and in vivo in the rat. Both the whole PSP extract and the water soluble fraction (0.5-20 microM) decreased the metabolism of tolbutamide to 4-hydroxytolbutamide in vitro. Enzyme kinetics studies showed that PSP inhibited tolbutamide 4-hydroxylase activity in a competitive, concentration-dependent manner. The whole PSP extract had a Ki value of 12.6 microM and IC50 at 18.4 microM, while the water extract had a Ki value of 6.9 microM and IC50 at 9.8 microM. Sulphaphenazole, a specific human CYP2C9 inhibitor, showed a Ki value of 30.8 microM and IC50 at 44.0 microM in the test system. In the pharmacokinetic studies in vivo, acute PSP (4 micromol/kg, i.p.) treatment did not produce significant changes in tolbutamide clearance, but produced a decrease in the Cinitial (7.4%) and an increase in the Vd (7.4%). Sub-chronic pre-treatment of PSP (1-2 micromol/kg/day, i.p.) for three days did not affect the clearance and AUC of tolbutamide, but the Cinitial was decreased, together with increases in the T1/2, and Vd. The formation of 4-hydroxytolbutamide in vivo was decreased in both acute and sub-chronic studies. Taken together, this study demonstrated the PSP can inhibit tolbutamide 4-hydroxylation both in vitro and in vivo. Despite the fact that CYP isoforms that metabolise tolbutamide are different between rat and human liver due to different catalytic characteristics, and rat studies may not be directly extrapolatable to man, the concomitant use of PSP with other CYP2C substrates should be carefully monitored." @default.
• W1978679154 created "2016-06-24" @default.
• W1978679154 creator A5022808477 @default.
• W1978679154 creator A5046030970 @default.
• W1978679154 creator A5067966617 @default.
• W1978679154 date "2006-08-01" @default.
• W1978679154 modified "2023-10-14" @default.
• W1978679154 title "Polysaccharide peptides from COV-1 strain of Coriolus versicolor inhibit tolbutamide 4-hydroxylation in the rat in vitro and in vivo" @default.
• W1978679154 cites W1578780451 @default.
• W1978679154 cites W1673905022 @default.
• W1978679154 cites W1746765074 @default.
• W1978679154 cites W1775749144 @default.
• W1978679154 cites W1947626504 @default.
• W1978679154 cites W1972249268 @default.
• W1978679154 cites W1985065867 @default.
• W1978679154 cites W1994831672 @default.
• W1978679154 cites W2017577604 @default.
• W1978679154 cites W2020326519 @default.
• W1978679154 cites W2028843420 @default.
• W1978679154 cites W2070670796 @default.
• W1978679154 cites W2074141414 @default.
• W1978679154 cites W2074299694 @default.
• W1978679154 cites W2084296498 @default.
• W1978679154 cites W2096561572 @default.
• W1978679154 cites W2101382082 @default.
• W1978679154 cites W2109453128 @default.
• W1978679154 cites W2110081538 @default.
• W1978679154 cites W2112381649 @default.
• W1978679154 cites W2139267967 @default.
• W1978679154 cites W2153341870 @default.
• W1978679154 cites W2169188579 @default.
• W1978679154 cites W2267140038 @default.
• W1978679154 cites W2416693749 @default.
• W1978679154 cites W31622143 @default.
• W1978679154 cites W8587632 @default.
• W1978679154 doi "https://doi.org/10.1016/j.fct.2006.03.007" @default.
• W1978679154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16698161" @default.
• W1978679154 hasPublicationYear "2006" @default.
• W1978679154 type Work @default.
• W1978679154 sameAs 1978679154 @default.
• W1978679154 citedByCount "11" @default.
• W1978679154 countsByYear W19786791542012 @default.
• W1978679154 countsByYear W19786791542016 @default.
• W1978679154 countsByYear W19786791542019 @default.
• W1978679154 crossrefType "journal-article" @default.
• W1978679154 hasAuthorship W1978679154A5022808477 @default.
• W1978679154 hasAuthorship W1978679154A5046030970 @default.
• W1978679154 hasAuthorship W1978679154A5067966617 @default.
• W1978679154 hasConcept C112705442 @default.
• W1978679154 hasConcept C134018914 @default.
• W1978679154 hasConcept C150903083 @default.
• W1978679154 hasConcept C181199279 @default.
• W1978679154 hasConcept C185592680 @default.
• W1978679154 hasConcept C202751555 @default.
• W1978679154 hasConcept C207001950 @default.
• W1978679154 hasConcept C2776054734 @default.
• W1978679154 hasConcept C2777752497 @default.
• W1978679154 hasConcept C2779306644 @default.
• W1978679154 hasConcept C2781109383 @default.
• W1978679154 hasConcept C55493867 @default.
• W1978679154 hasConcept C86803240 @default.
• W1978679154 hasConcept C87644729 @default.
• W1978679154 hasConcept C98274493 @default.
• W1978679154 hasConceptScore W1978679154C112705442 @default.
• W1978679154 hasConceptScore W1978679154C134018914 @default.
• W1978679154 hasConceptScore W1978679154C150903083 @default.
• W1978679154 hasConceptScore W1978679154C181199279 @default.
• W1978679154 hasConceptScore W1978679154C185592680 @default.
• W1978679154 hasConceptScore W1978679154C202751555 @default.
• W1978679154 hasConceptScore W1978679154C207001950 @default.
• W1978679154 hasConceptScore W1978679154C2776054734 @default.
• W1978679154 hasConceptScore W1978679154C2777752497 @default.
• W1978679154 hasConceptScore W1978679154C2779306644 @default.
• W1978679154 hasConceptScore W1978679154C2781109383 @default.
• W1978679154 hasConceptScore W1978679154C55493867 @default.
• W1978679154 hasConceptScore W1978679154C86803240 @default.
• W1978679154 hasConceptScore W1978679154C87644729 @default.
• W1978679154 hasConceptScore W1978679154C98274493 @default.
• W1978679154 hasIssue "8" @default.
• W1978679154 hasLocation W19786791541 @default.
• W1978679154 hasLocation W19786791542 @default.
• W1978679154 hasOpenAccess W1978679154 @default.
• W1978679154 hasPrimaryLocation W19786791541 @default.
• W1978679154 hasRelatedWork W1872726898 @default.
• W1978679154 hasRelatedWork W1947626504 @default.
• W1978679154 hasRelatedWork W2004556784 @default.
• W1978679154 hasRelatedWork W2037070237 @default.
• W1978679154 hasRelatedWork W2057107688 @default.
• W1978679154 hasRelatedWork W2138387131 @default.
• W1978679154 hasRelatedWork W2388069209 @default.
• W1978679154 hasRelatedWork W2582907174 @default.
• W1978679154 hasRelatedWork W2753834235 @default.
• W1978679154 hasRelatedWork W2337404274 @default.
• W1978679154 hasVolume "44" @default.
• W1978679154 isParatext "false" @default.
• W1978679154 isRetracted "false" @default.
• W1978679154 magId "1978679154" @default.
• W1978679154 workType "article" @default.