Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978683604> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1978683604 endingPage "363" @default.
- W1978683604 startingPage "357" @default.
- W1978683604 abstract "High linear energy transfer (LET) fast neutrons for the local control of advanced head and neck tumours are currently being evaluated at several centres. Fast neutrons are believed to produce more direct, and less OH. mediated damage than photons, and consequently be less affected by intracellular thiol levels. Chemoresistant tumours with elevated thiol levels may therefore be more effectively controlled by fast neutron therapy than by photons. The “in vitro” radiation response of melphalan sensitive and resistant human ovarian tumour cell lines has demonstrated that melphalan resistance confers a 1.5-fold level of cross-resistance to photons, primarily attributable to a 2-fold decrease in the α component in the resistant OAW42/MER cell line. Pretreatment of the melphalan-resistant line with the thiol depleting agent buthionine sulphoximine (BSO) restored the magnitude of α to a value similar to that in the chemosensitive cell line. The survival curves of these cell lines following neutron irradiation were near exponential, with similar values of α. This study has demonstrated that melphalan resistant tumour cells are cross-resistant to photon irradiation, but not to fast neutrons. The mechanism of cross-resistance has yet to be determined, but glutathione (GSH) appears to be involved." @default.
- W1978683604 created "2016-06-24" @default.
- W1978683604 creator A5006514785 @default.
- W1978683604 creator A5016987788 @default.
- W1978683604 creator A5023752965 @default.
- W1978683604 creator A5025523866 @default.
- W1978683604 creator A5051102037 @default.
- W1978683604 date "1990-08-01" @default.
- W1978683604 modified "2023-09-26" @default.
- W1978683604 title "Melphalan resistant human ovarian tumour cells are cross-resistant to photons, but not to high LET neutrons" @default.
- W1978683604 cites W1481581408 @default.
- W1978683604 cites W1499822007 @default.
- W1978683604 cites W1967912912 @default.
- W1978683604 cites W1974375149 @default.
- W1978683604 cites W2005447998 @default.
- W1978683604 cites W2020803654 @default.
- W1978683604 cites W2023178182 @default.
- W1978683604 cites W2023676537 @default.
- W1978683604 cites W2039405617 @default.
- W1978683604 cites W2040699587 @default.
- W1978683604 cites W2051202148 @default.
- W1978683604 cites W2057980517 @default.
- W1978683604 cites W2065500401 @default.
- W1978683604 cites W2066752911 @default.
- W1978683604 cites W2072049169 @default.
- W1978683604 cites W2075995445 @default.
- W1978683604 cites W2118519973 @default.
- W1978683604 cites W2120114097 @default.
- W1978683604 cites W2125837976 @default.
- W1978683604 cites W2167120728 @default.
- W1978683604 cites W2210833679 @default.
- W1978683604 cites W2255046153 @default.
- W1978683604 cites W2313928886 @default.
- W1978683604 doi "https://doi.org/10.1016/0167-8140(90)90116-e" @default.
- W1978683604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2244022" @default.
- W1978683604 hasPublicationYear "1990" @default.
- W1978683604 type Work @default.
- W1978683604 sameAs 1978683604 @default.
- W1978683604 citedByCount "19" @default.
- W1978683604 countsByYear W19786836042013 @default.
- W1978683604 crossrefType "journal-article" @default.
- W1978683604 hasAuthorship W1978683604A5006514785 @default.
- W1978683604 hasAuthorship W1978683604A5016987788 @default.
- W1978683604 hasAuthorship W1978683604A5023752965 @default.
- W1978683604 hasAuthorship W1978683604A5025523866 @default.
- W1978683604 hasAuthorship W1978683604A5051102037 @default.
- W1978683604 hasConcept C111337013 @default.
- W1978683604 hasConcept C121332964 @default.
- W1978683604 hasConcept C152568617 @default.
- W1978683604 hasConcept C177322064 @default.
- W1978683604 hasConcept C185544564 @default.
- W1978683604 hasConcept C185592680 @default.
- W1978683604 hasConcept C2776694085 @default.
- W1978683604 hasConcept C2778684742 @default.
- W1978683604 hasConcept C2989005 @default.
- W1978683604 hasConcept C502942594 @default.
- W1978683604 hasConcept C54355233 @default.
- W1978683604 hasConcept C71924100 @default.
- W1978683604 hasConcept C81885089 @default.
- W1978683604 hasConcept C86803240 @default.
- W1978683604 hasConceptScore W1978683604C111337013 @default.
- W1978683604 hasConceptScore W1978683604C121332964 @default.
- W1978683604 hasConceptScore W1978683604C152568617 @default.
- W1978683604 hasConceptScore W1978683604C177322064 @default.
- W1978683604 hasConceptScore W1978683604C185544564 @default.
- W1978683604 hasConceptScore W1978683604C185592680 @default.
- W1978683604 hasConceptScore W1978683604C2776694085 @default.
- W1978683604 hasConceptScore W1978683604C2778684742 @default.
- W1978683604 hasConceptScore W1978683604C2989005 @default.
- W1978683604 hasConceptScore W1978683604C502942594 @default.
- W1978683604 hasConceptScore W1978683604C54355233 @default.
- W1978683604 hasConceptScore W1978683604C71924100 @default.
- W1978683604 hasConceptScore W1978683604C81885089 @default.
- W1978683604 hasConceptScore W1978683604C86803240 @default.
- W1978683604 hasIssue "4" @default.
- W1978683604 hasLocation W19786836041 @default.
- W1978683604 hasLocation W19786836042 @default.
- W1978683604 hasOpenAccess W1978683604 @default.
- W1978683604 hasPrimaryLocation W19786836041 @default.
- W1978683604 hasRelatedWork W143499428 @default.
- W1978683604 hasRelatedWork W1980885803 @default.
- W1978683604 hasRelatedWork W1990779598 @default.
- W1978683604 hasRelatedWork W1998405148 @default.
- W1978683604 hasRelatedWork W2053953431 @default.
- W1978683604 hasRelatedWork W2087777165 @default.
- W1978683604 hasRelatedWork W2090914117 @default.
- W1978683604 hasRelatedWork W2147133887 @default.
- W1978683604 hasRelatedWork W2372903689 @default.
- W1978683604 hasRelatedWork W2915404247 @default.
- W1978683604 hasVolume "18" @default.
- W1978683604 isParatext "false" @default.
- W1978683604 isRetracted "false" @default.
- W1978683604 magId "1978683604" @default.
- W1978683604 workType "article" @default.