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• W1978684471 abstract "The effects of bidisomide, an antiarrhythmic agent, on sodium current (INa) in isolated rat ventricular myocytes were investigated using a whole cell voltage clamp method. Bidisomide blocked INa with a Ki of 214 μM at a holding potential of -140 mV. The blockade of INa was enhanced at a less negative holding potential of -100 mV with a Ki of 21 μM. Bidisomide shifted the steady state inactivation curve to a negative potential direction by 20 mV without a significant change in the slope factor. Bidisomide slowed the time course of recovery of INa at a holding potential of -140 mV with a slow recovery phase. The time constant ofrecovery phase for bidisomide, disopyramide and mexiletine were 2703, 1858 and 757 ms, respectively. The development of the block of INa consisted of two phases in the presence of bidisomide. The fast and slow time constants were 11 and 648 ms. Bidisomide produced a use-dependent block of INa when the depolarizing pulse was repeated at 1-3Hz. Our results indicate that bidisomide binds to rat cardiac sodium channels and that the dissociation kinetics of bidisomide from the inactivated sodium channel is slower than that of disopyramide." @default.
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• W1978684471 date "2001-01-01" @default.
• W1978684471 modified "2023-10-14" @default.
• W1978684471 title "Electrophysiologic Effects of an Antiarrhythmic Agent, Bidisomide, on Sodium Current in Isolated Rat Ventricular Myocytes: Comparison With Mexiletine and Disopyramide" @default.
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• W1978684471 doi "https://doi.org/10.1254/jjp.86.23" @default.
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