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- W1978684763 abstract "Cells of human gastric adenocarcinoma and of tissue from the antral mucosa believed to be normal were incubated in an isotonic medium containing glucose 1-phosphate and examined by transmission electron microscopy in order to determine whether both the nuclei and cytoplasm of such cells were capable of synthesizing the substrate to glycogen. Appropriate control incubations, in which glucose 1-phosphate was not added to the medium, were also carried out. Local aggregation of small dense particles were observed in both the nuclei and cytoplasm of the tumour cells after incubation with the substrate for 20–30 min. The number of aggregates seen in the nuclei were much less than generally observed in the cytoplasm; the former aggregates were found in the interchromatin regions and their particles were usually about twice the size (100–130nm) of those seen in the cytoplasm (50–70nm). In the cytoplasm the aggregates were usually enclosed by a membrane. Similar deposits were not seen in either the cells used in the control incubations or in the normal cells incubated with the substrate. It is considered that at least in vitro both the nucleus and cytoplasm of the cells of the adenocarcinoma possessed a phosphorylase glycosyltransferase system capable of synthesizing glycogen particles from glucose 1-phosphate." @default.
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- W1978684763 date "1976-01-01" @default.
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- W1978684763 title "Synthesis and intracellular localization of glycogen particles in human gastric adenocarcinoma" @default.
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- W1978684763 doi "https://doi.org/10.1016/0047-7206(76)90008-x" @default.
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