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• W1978689443 abstract "Primary effusion lymphoma (PEL) is a rare aggressive subset of non-Hodgkin B-cell lymphoma. It is caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV8). It occurs mainly, but not exclusively, in HIV-positive patients. PEL predominantly develops in serous cavities and occasionally in extracavitary regions. PEL carries a very poor prognosis with a median survival time of <6 months. Indeed, currently used treatment modalities such as CHOP chemotherapy are far from achieving complete and sustainable remission. Therefore, there is no clear standard of care established in the treatment of PEL patients, stressing the need for novel-targeted approaches. Here, we have attempted a comprehensive assessment of the treatment of PEL, discussed avant-garde therapies and updated the state of preclinical research with promising clinical applications in the field. These include inhibitors of viral replication, modulators of cell signaling and inflammation, nuclear factor kappa B (NF-κB) and histone deacetylase inhibitors, and recently the combination of arsenic trioxide and interferon-alpha. Some of these targeted therapies have not yet reached clinical studies, although others were used in a few individual case reports with low numbers of patients. We also describe the first case of a 77-year-old, HIV-negative, HHV8-positive patient diagnosed with PEL limited to the pleural and peritoneal cavities. He received lenalidomide 25 mg/day for 21 days every 28 days. Treatment was well tolerated with no side effects. He rapidly improved after 1 month of treatment and progressively achieved complete remission persistent after 18 months of therapy. We believe that this review will bridge an important gap between classical chemotherapy and modern approaches of targeted therapy. Finally, our findings warrant further evaluation of lenalidomide in future prospective clinical studies." @default.
• W1978689443 created "2016-06-24" @default.
• W1978689443 creator A5005375238 @default.
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• W1978689443 date "2014-03-07" @default.
• W1978689443 modified "2023-10-06" @default.
• W1978689443 title "Primary effusion lymphoma in an elderly patient effectively treated by lenalidomide: case report and review of literature" @default.
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• W1978689443 doi "https://doi.org/10.1038/bcj.2014.6" @default.
• W1978689443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3972705" @default.
• W1978689443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24608734" @default.
• W1978689443 hasPublicationYear "2014" @default.
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