FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978689462> ?p ?o ?g. }

• W1978689462 endingPage "102" @default.
• W1978689462 startingPage "97" @default.
• W1978689462 abstract "In an attempt to develop highly efficient antibody—drug conjugates for passive immunotherapy of cancer the A-chain of the potent toxin, ricin, was coupled to antibodies in order to render them specifically cytotoxic for target cells without the participation of complement. The antibody—toxin conjugates (immunotoxins) showed no loss of antibody or A-chain activity. In vitro, highly purified A-chain was about 5000 times less toxic on HeLa cells than whole ricin. Unconjugated A-chain made no difference between TNP-HeLa and HeLa cells but when coupled to anti-DPN antibodies it became about 500 times more cytotoxic to TNP-HeLa cells than to HeLa cells. In vivo A-chain (LD50: 20 mg/kg) was about 3000 times less toxic than whole ricin and treatment with immunotoxin significantly inhibited tumor take and tumor growth of TNP-HeLa cells in nude mice." @default.
• W1978689462 created "2016-06-24" @default.
• W1978689462 creator A5000653236 @default.
• W1978689462 creator A5013533653 @default.
• W1978689462 creator A5025803443 @default.
• W1978689462 creator A5029380522 @default.
• W1978689462 creator A5040376843 @default.
• W1978689462 creator A5041961843 @default.
• W1978689462 creator A5045428932 @default.
• W1978689462 creator A5048369934 @default.
• W1978689462 creator A5064078420 @default.
• W1978689462 creator A5064720570 @default.
• W1978689462 creator A5066385407 @default.
• W1978689462 creator A5076117174 @default.
• W1978689462 creator A5087613050 @default.
• W1978689462 creator A5088871659 @default.
• W1978689462 date "1980-10-01" @default.
• W1978689462 modified "2023-09-24" @default.
• W1978689462 title "High specific cytotoxicity of antibody-toxin hybrid molecules (immunotoxins) for target cells" @default.
• W1978689462 cites W1487184957 @default.
• W1978689462 cites W1564906830 @default.
• W1978689462 cites W1586791994 @default.
• W1978689462 cites W1893651774 @default.
• W1978689462 cites W1991874195 @default.
• W1978689462 cites W1994088967 @default.
• W1978689462 cites W1994649977 @default.
• W1978689462 cites W2005012244 @default.
• W1978689462 cites W2010815223 @default.
• W1978689462 cites W2039271628 @default.
• W1978689462 cites W2063265125 @default.
• W1978689462 doi "https://doi.org/10.1016/0165-2478(80)90057-7" @default.
• W1978689462 hasPublicationYear "1980" @default.
• W1978689462 type Work @default.
• W1978689462 sameAs 1978689462 @default.
• W1978689462 citedByCount "53" @default.
• W1978689462 countsByYear W19786894622013 @default.
• W1978689462 countsByYear W19786894622020 @default.
• W1978689462 crossrefType "journal-article" @default.
• W1978689462 hasAuthorship W1978689462A5000653236 @default.
• W1978689462 hasAuthorship W1978689462A5013533653 @default.
• W1978689462 hasAuthorship W1978689462A5025803443 @default.
• W1978689462 hasAuthorship W1978689462A5029380522 @default.
• W1978689462 hasAuthorship W1978689462A5040376843 @default.
• W1978689462 hasAuthorship W1978689462A5041961843 @default.
• W1978689462 hasAuthorship W1978689462A5045428932 @default.
• W1978689462 hasAuthorship W1978689462A5048369934 @default.
• W1978689462 hasAuthorship W1978689462A5064078420 @default.
• W1978689462 hasAuthorship W1978689462A5064720570 @default.
• W1978689462 hasAuthorship W1978689462A5066385407 @default.
• W1978689462 hasAuthorship W1978689462A5076117174 @default.
• W1978689462 hasAuthorship W1978689462A5087613050 @default.
• W1978689462 hasAuthorship W1978689462A5088871659 @default.
• W1978689462 hasConcept C109316439 @default.
• W1978689462 hasConcept C115085202 @default.
• W1978689462 hasConcept C150903083 @default.
• W1978689462 hasConcept C153911025 @default.
• W1978689462 hasConcept C154317977 @default.
• W1978689462 hasConcept C159654299 @default.
• W1978689462 hasConcept C185592680 @default.
• W1978689462 hasConcept C202751555 @default.
• W1978689462 hasConcept C203014093 @default.
• W1978689462 hasConcept C207001950 @default.
• W1978689462 hasConcept C2777200438 @default.
• W1978689462 hasConcept C2777366897 @default.
• W1978689462 hasConcept C2777367657 @default.
• W1978689462 hasConcept C55493867 @default.
• W1978689462 hasConcept C86803240 @default.
• W1978689462 hasConceptScore W1978689462C109316439 @default.
• W1978689462 hasConceptScore W1978689462C115085202 @default.
• W1978689462 hasConceptScore W1978689462C150903083 @default.
• W1978689462 hasConceptScore W1978689462C153911025 @default.
• W1978689462 hasConceptScore W1978689462C154317977 @default.
• W1978689462 hasConceptScore W1978689462C159654299 @default.
• W1978689462 hasConceptScore W1978689462C185592680 @default.
• W1978689462 hasConceptScore W1978689462C202751555 @default.
• W1978689462 hasConceptScore W1978689462C203014093 @default.
• W1978689462 hasConceptScore W1978689462C207001950 @default.
• W1978689462 hasConceptScore W1978689462C2777200438 @default.
• W1978689462 hasConceptScore W1978689462C2777366897 @default.
• W1978689462 hasConceptScore W1978689462C2777367657 @default.
• W1978689462 hasConceptScore W1978689462C55493867 @default.
• W1978689462 hasConceptScore W1978689462C86803240 @default.
• W1978689462 hasIssue "2" @default.
• W1978689462 hasLocation W19786894621 @default.
• W1978689462 hasOpenAccess W1978689462 @default.
• W1978689462 hasPrimaryLocation W19786894621 @default.
• W1978689462 hasRelatedWork W141097586 @default.
• W1978689462 hasRelatedWork W1978689462 @default.
• W1978689462 hasRelatedWork W2000578943 @default.
• W1978689462 hasRelatedWork W2025572770 @default.
• W1978689462 hasRelatedWork W2049463037 @default.
• W1978689462 hasRelatedWork W2117248774 @default.
• W1978689462 hasRelatedWork W2133798417 @default.
• W1978689462 hasRelatedWork W2352626293 @default.
• W1978689462 hasRelatedWork W3148689011 @default.
• W1978689462 hasRelatedWork W4238918708 @default.
• W1978689462 hasVolume "2" @default.
• W1978689462 isParatext "false" @default.

• next