FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978693516> ?p ?o ?g. }

• W1978693516 endingPage "1626" @default.
• W1978693516 startingPage "1612" @default.
• W1978693516 abstract "The OmpR/PhoB family of response regulators (RRs) is the largest class of two-component system signal transduction proteins. Extensive biochemical and structural characterization of these transcription factors has provided insights into their activation and DNA-binding mechanisms. For the most part, OmpR/PhoB family proteins are thought to become activated through phosphorylation from their cognate histidine kinase partners, which in turn facilitates an allosteric change in the RR, enabling homodimerization and subsequently enhanced DNA binding. Incongruently, it has been suggested that OmpR, the eponymous member of this RR family, becomes activated via different mechanisms, whereby DNA binding plays a central role in facilitating dimerization and phosphorylation. Characterization of the rate and extent of the phosphorylation of OmpR and OmpR DNA-binding mutants following activation of the EnvZ/OmpR two-component system shows that DNA binding is not essential for phosphorylation of OmpR in vivo. In addition, detailed analyses of the energetics of DNA binding and dimerization of OmpR in both its unphosphorylated and phosphorylated state indicate that phosphorylation enhances OmpR dimerization and that this dimerization enhancement is the energetic driving force for phosphorylation-mediated regulation of OmpR–DNA binding. These findings suggest that OmpR phosphorylation-mediated activation follows the same paradigm as the other members of the OmpR/PhoB family of RRs in contrast to previously proposed models of OmpR activation." @default.
• W1978693516 created "2016-06-24" @default.
• W1978693516 creator A5027036766 @default.
• W1978693516 creator A5039365328 @default.
• W1978693516 creator A5053596221 @default.
• W1978693516 date "2013-05-01" @default.
• W1978693516 modified "2023-10-16" @default.
• W1978693516 title "Comprehensive Analysis of OmpR Phosphorylation, Dimerization, and DNA Binding Supports a Canonical Model for Activation" @default.
• W1978693516 cites W1483663613 @default.
• W1978693516 cites W1539719002 @default.
• W1978693516 cites W1551452913 @default.
• W1978693516 cites W1598930222 @default.
• W1978693516 cites W1799355856 @default.
• W1978693516 cites W1833346845 @default.
• W1978693516 cites W1858893212 @default.
• W1978693516 cites W1934365823 @default.
• W1978693516 cites W1975008340 @default.
• W1978693516 cites W1975675450 @default.
• W1978693516 cites W1985260825 @default.
• W1978693516 cites W1992558829 @default.
• W1978693516 cites W1999746361 @default.
• W1978693516 cites W2005371789 @default.
• W1978693516 cites W2007897629 @default.
• W1978693516 cites W2008435007 @default.
• W1978693516 cites W2016585890 @default.
• W1978693516 cites W2017178787 @default.
• W1978693516 cites W2021290640 @default.
• W1978693516 cites W2022188938 @default.
• W1978693516 cites W2033210346 @default.
• W1978693516 cites W2038727507 @default.
• W1978693516 cites W2039287501 @default.
• W1978693516 cites W2044431824 @default.
• W1978693516 cites W2044581175 @default.
• W1978693516 cites W2053004995 @default.
• W1978693516 cites W2057107775 @default.
• W1978693516 cites W2057460911 @default.
• W1978693516 cites W2058473414 @default.
• W1978693516 cites W2060289339 @default.
• W1978693516 cites W2063602441 @default.
• W1978693516 cites W2081959472 @default.
• W1978693516 cites W2082089547 @default.
• W1978693516 cites W2083726121 @default.
• W1978693516 cites W2084001324 @default.
• W1978693516 cites W2087025822 @default.
• W1978693516 cites W2088880573 @default.
• W1978693516 cites W2092620403 @default.
• W1978693516 cites W2108419658 @default.
• W1978693516 cites W2110343075 @default.
• W1978693516 cites W2114798043 @default.
• W1978693516 cites W2144529284 @default.
• W1978693516 cites W2147776446 @default.
• W1978693516 cites W2148138345 @default.
• W1978693516 cites W2149875912 @default.
• W1978693516 cites W2150015168 @default.
• W1978693516 cites W2157186467 @default.
• W1978693516 cites W2158418610 @default.
• W1978693516 cites W2160084442 @default.
• W1978693516 cites W2164367233 @default.
• W1978693516 doi "https://doi.org/10.1016/j.jmb.2013.02.003" @default.
• W1978693516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3646996" @default.
• W1978693516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23399542" @default.
• W1978693516 hasPublicationYear "2013" @default.
• W1978693516 type Work @default.
• W1978693516 sameAs 1978693516 @default.
• W1978693516 citedByCount "46" @default.
• W1978693516 countsByYear W19786935162013 @default.
• W1978693516 countsByYear W19786935162014 @default.
• W1978693516 countsByYear W19786935162015 @default.
• W1978693516 countsByYear W19786935162016 @default.
• W1978693516 countsByYear W19786935162017 @default.
• W1978693516 countsByYear W19786935162018 @default.
• W1978693516 countsByYear W19786935162019 @default.
• W1978693516 countsByYear W19786935162020 @default.
• W1978693516 countsByYear W19786935162021 @default.
• W1978693516 countsByYear W19786935162022 @default.
• W1978693516 countsByYear W19786935162023 @default.
• W1978693516 crossrefType "journal-article" @default.
• W1978693516 hasAuthorship W1978693516A5027036766 @default.
• W1978693516 hasAuthorship W1978693516A5039365328 @default.
• W1978693516 hasAuthorship W1978693516A5053596221 @default.
• W1978693516 hasBestOaLocation W19786935162 @default.
• W1978693516 hasConcept C104317684 @default.
• W1978693516 hasConcept C11960822 @default.
• W1978693516 hasConcept C138223613 @default.
• W1978693516 hasConcept C143065580 @default.
• W1978693516 hasConcept C185592680 @default.
• W1978693516 hasConcept C2778905257 @default.
• W1978693516 hasConcept C2781196521 @default.
• W1978693516 hasConcept C552990157 @default.
• W1978693516 hasConcept C55493867 @default.
• W1978693516 hasConcept C62478195 @default.
• W1978693516 hasConcept C86339819 @default.
• W1978693516 hasConcept C86803240 @default.
• W1978693516 hasConcept C94966510 @default.
• W1978693516 hasConcept C95444343 @default.
• W1978693516 hasConceptScore W1978693516C104317684 @default.
• W1978693516 hasConceptScore W1978693516C11960822 @default.
• W1978693516 hasConceptScore W1978693516C138223613 @default.

• next