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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978693527> ?p ?o ?g. }

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• W1978693527 startingPage "3894" @default.
• W1978693527 abstract "Manganese porphyrin-linker-triple-helix-forming oligonucleotide molecules were prepared and their ability to cleave in vitro a double-stranded DNA target present in the HIV-1 genome was studied. The nature of the linker is a determining factor of the cleavage efficiency. Cleavage yields as high as 80% were observed when the linker was a spermine residue and in the absence of a large excess of free spermlne known to stabilize triplex structures. The hydrophobic nature of aliphatic diamine linker modified the cleaver-DNA interactions and reduced the efficiency of DNA cleavage." @default.
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• W1978693527 date "1995-01-01" @default.
• W1978693527 modified "2023-09-30" @default.
• W1978693527 title "Cleavage of double-stranded DNA by ‘metalloporphyrin-linker oligonucleotide’ molecules: influence of the linker" @default.
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• W1978693527 doi "https://doi.org/10.1093/nar/23.19.3894" @default.
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