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• W1978695761 abstract "Background Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) are devastating clinical syndromes associated with a high mortality rate. We examined the preventive effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in a mouse ALI/ARDS model induced by lipopolysaccharide (LPS). Materials and methods Mice were injected with LPS (10–20 mg/kg) with or without rhG-CSF pretreatment (250 mg/kg/d). Survival rate, cytokine mRNA expression, and pathologic findings were examined. Results The 96-h survival rate of the control group was 20%. Survival was significantly increased to 80% in rhG-CSF-treated animals. LPS-induced destruction of the alveolar structure was not observed in the rhG-CSF group. Pretreatment with rhG-CSF led to significantly lower mRNA expression of TNF-α and IL-1β in the lung 24 h after LPS administration and significantly higher IL-10 expression 96 h after LPS administration. Immunohistochemical analysis revealed that treatment with rhG-CSF also prevented the up-regulation of TNF-α and IL-1β protein expression in alveolar macrophages. Conclusion Treatment with rhG-CSF prevents the development of ALI/ARDS induced by LPS by affecting the production of pro- and anti-inflammatory cytokines and may be promising in clinical applications." @default.
• W1978695761 created "2016-06-24" @default.
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• W1978695761 date "2012-11-01" @default.
• W1978695761 modified "2023-10-03" @default.
• W1978695761 title "Preventive effect of G-CSF on acute lung injury via alveolar macrophage regulation" @default.
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• W1978695761 doi "https://doi.org/10.1016/j.jss.2011.12.026" @default.
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