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- W1978697594 abstract "The clonal origin of tumors was studied in two multifocal hepatocellularcarcinomas arising from hepatitis B viral cirrhosis. DNA extracted from several tumor nodules was analyzed for the presence of hepatitis B virus genome by the Southern blot technique. Unique clonal integration of the viral DNA sequences occurred in both cases. In each case, identical integration bands occurred among multiple nodules of liver tumor. These results are strong evidence of a unicentric origin of these tumors, although the tumors' gross appearance is suggestive of multifocal origin." @default.
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- W1978697594 date "1988-04-01" @default.
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- W1978697594 title "Clonal origin of hepatitis B virus-associated hepatocellular carcinoma" @default.
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- W1978697594 doi "https://doi.org/10.1016/s0046-8177(88)80488-x" @default.
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