FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978704069> ?p ?o ?g. }

• W1978704069 endingPage "192" @default.
• W1978704069 startingPage "180" @default.
• W1978704069 abstract "We tested six additional chemicals (acetaldehyde, benomyl, diethylstilboestrol, diethylstilboestrol dipropionate, griseofulvin, and mercaptoethanol) for in vitro systems of the coordinated programme to study aneuploidy induction sponsored by the Commission of the European Communities in two in vitro test systems. Using Saccharomyces cerevisiae D61.M (mitotic chromosomal malsegregation assay), benomyl showed a dose-dependent increase in the frequency of chromosomal malsegregation with a lowest effective dose tested (LEDT) of 30 μg/ml (0.1 mM). Diethylstilboestrol (DES) showed solvent-dependent effects. DES dissolved in ethanol induced an increase in chromosomal malsegregation as well as in the frequency of total resistant colonies (mutations and recombinations) with a LEDT arround 13 μg/ml (0.048 mM). Using dimethylsulfoxide as the solvent, no increases were observed with DES up to 333 μg/ml (1.24 mM). Acetaldehyde induced an increase in chromosomal malsegregation with the cold treatment protocol (LEDT: 1.25 μl/ml (21 mM) and 0.75 μ/ml (13 mM), respectively) but no increase with the overnight protocol (highest dose tested (HDT): 1.75 μ/ml; 30 mM). Concerning the frequency of total cycloheximide-resistant colonies (mutations and recombinations) increases were obtained with both protocols. The other three compounds were negative when tested up to toxic doses (survival below 10%), up to the maximum solubility in the solvent used or up to heavy precipitation in the incubation mix. The HDT were 333 μ/ml (0.88 mM) for diethylstilboestrol dipropionate, 1,600 μg/ml (4.5 mM) for griseofulvin and 0.5 μl/ml (7 mM) for mercaptoethanol. Concerning effects on porcine brain tubulin assembly in vitro, diethylstilboestrol and griseofulvin inhibited the assembly process. The IC30% (30% inhibition concentration) values were 12.5 μM and 100 μM for DES and griseofulvin, respectively. Mercaptoethanol showed no effects up to 50 mM. © 1993 Wiley-Liss, Inc." @default.
• W1978704069 created "2016-06-24" @default.
• W1978704069 creator A5009318870 @default.
• W1978704069 creator A5036858038 @default.
• W1978704069 creator A5037079555 @default.
• W1978704069 date "1993-01-01" @default.
• W1978704069 modified "2023-10-03" @default.
• W1978704069 title "Analysis of the six additional chemicals for in vitro assays of the european economic communities' EEC aneuploidy programme using saccharomyces cerevisiae D61.M and the in vitro porcine brain tubulin assembly assay" @default.
• W1978704069 cites W1519795388 @default.
• W1978704069 cites W1601932516 @default.
• W1978704069 cites W1856508030 @default.
• W1978704069 cites W1964281070 @default.
• W1978704069 cites W1970758615 @default.
• W1978704069 cites W1971864478 @default.
• W1978704069 cites W1979487639 @default.
• W1978704069 cites W1979676560 @default.
• W1978704069 cites W1982821017 @default.
• W1978704069 cites W1992237040 @default.
• W1978704069 cites W1993194123 @default.
• W1978704069 cites W1994480503 @default.
• W1978704069 cites W1998760208 @default.
• W1978704069 cites W2002232269 @default.
• W1978704069 cites W2003913044 @default.
• W1978704069 cites W2009046319 @default.
• W1978704069 cites W2009582023 @default.
• W1978704069 cites W2012686059 @default.
• W1978704069 cites W2023149393 @default.
• W1978704069 cites W2024275699 @default.
• W1978704069 cites W2028045940 @default.
• W1978704069 cites W2030834879 @default.
• W1978704069 cites W2032668403 @default.
• W1978704069 cites W2033333080 @default.
• W1978704069 cites W2039829159 @default.
• W1978704069 cites W2041509866 @default.
• W1978704069 cites W2044969577 @default.
• W1978704069 cites W2045656291 @default.
• W1978704069 cites W2047869099 @default.
• W1978704069 cites W2052034395 @default.
• W1978704069 cites W2053012139 @default.
• W1978704069 cites W2062143530 @default.
• W1978704069 cites W2066291530 @default.
• W1978704069 cites W2067855756 @default.
• W1978704069 cites W2070277840 @default.
• W1978704069 cites W2078506286 @default.
• W1978704069 cites W2078773272 @default.
• W1978704069 cites W2081922322 @default.
• W1978704069 cites W2087074707 @default.
• W1978704069 cites W2092992968 @default.
• W1978704069 cites W2093523311 @default.
• W1978704069 cites W2100837269 @default.
• W1978704069 cites W2110994703 @default.
• W1978704069 cites W2113631456 @default.
• W1978704069 cites W2125127914 @default.
• W1978704069 cites W2142650651 @default.
• W1978704069 cites W2157175092 @default.
• W1978704069 cites W2167973356 @default.
• W1978704069 cites W4211178099 @default.
• W1978704069 cites W4238255197 @default.
• W1978704069 cites W4248876235 @default.
• W1978704069 cites W4293247451 @default.
• W1978704069 doi "https://doi.org/10.1002/em.2850210211" @default.
• W1978704069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8444145" @default.
• W1978704069 hasPublicationYear "1993" @default.
• W1978704069 type Work @default.
• W1978704069 sameAs 1978704069 @default.
• W1978704069 citedByCount "14" @default.
• W1978704069 crossrefType "journal-article" @default.
• W1978704069 hasAuthorship W1978704069A5009318870 @default.
• W1978704069 hasAuthorship W1978704069A5036858038 @default.
• W1978704069 hasAuthorship W1978704069A5037079555 @default.
• W1978704069 hasConcept C142724271 @default.
• W1978704069 hasConcept C178790620 @default.
• W1978704069 hasConcept C185592680 @default.
• W1978704069 hasConcept C202751555 @default.
• W1978704069 hasConcept C2777576037 @default.
• W1978704069 hasConcept C2777595113 @default.
• W1978704069 hasConcept C2778959862 @default.
• W1978704069 hasConcept C2779222958 @default.
• W1978704069 hasConcept C2779819575 @default.
• W1978704069 hasConcept C2780161600 @default.
• W1978704069 hasConcept C2780626286 @default.
• W1978704069 hasConcept C29730261 @default.
• W1978704069 hasConcept C33070731 @default.
• W1978704069 hasConcept C55493867 @default.
• W1978704069 hasConcept C59822182 @default.
• W1978704069 hasConcept C71924100 @default.
• W1978704069 hasConcept C74600772 @default.
• W1978704069 hasConcept C86803240 @default.
• W1978704069 hasConceptScore W1978704069C142724271 @default.
• W1978704069 hasConceptScore W1978704069C178790620 @default.
• W1978704069 hasConceptScore W1978704069C185592680 @default.
• W1978704069 hasConceptScore W1978704069C202751555 @default.
• W1978704069 hasConceptScore W1978704069C2777576037 @default.
• W1978704069 hasConceptScore W1978704069C2777595113 @default.
• W1978704069 hasConceptScore W1978704069C2778959862 @default.
• W1978704069 hasConceptScore W1978704069C2779222958 @default.
• W1978704069 hasConceptScore W1978704069C2779819575 @default.
• W1978704069 hasConceptScore W1978704069C2780161600 @default.

• next