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- W1978709354 abstract "Chinese hamster V79 cells were treated with cyclophosphamide (CP) and various concentrations of S-15 mix in vitro, and then examined for chromosome aberrations, sister chromatid exchange (SCE) and induction of 8-azaguanine (8AG)-resistant mutations. Cells from hamster embryos treated with CP in utero by intraperitoneal injection were tested for drug-resistant mutation. CP caused a marked dose-dependent increase of chromosome aberrations, SCE and drug resistant mutations in V79 cells in the presence of lower concentrations of S-15. The inductions of 8AG-resistant mutations in V79 cells by CP with 1% S-15 were 7.4 times higher than those in the control. Trans- placentral treatment with CP also caused a marked increase in 8AG-resistant mutations of hamster embryonic cells." @default.
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- W1978709354 date "1983-01-01" @default.
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- W1978709354 title "Mutagenicity of cyclophosphamide in mammalian cells treated in vitro and in utero." @default.
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- W1978709354 doi "https://doi.org/10.1266/jjg.58.23" @default.
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