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• W1978709436 abstract "Nitric oxide (NO) can have opposite effects on peripheral sensory neuron sensitivity depending on the concentration and source of NO, and the experimental setting. The aim of this study was to determine the role of endogenous NO production in the regulation of mechanosensitive Ca2+ influx of dorsal root ganglion (DRG) neurons. Adult mouse DRG neurons were grown in primary culture for 2–5 days, loaded with Fura-2, and tested for mechanically mediated changes in [Ca2+]i by fluorescent ratio imaging. In the presence of the NOS inhibitors l-NAME, TRIM, or 7-NI, but not the inactive analogue d-NAME, peak [Ca2+]i transients to mechanical stimulation were increased more than 2-fold. Neither La3+ (25 μM), an inhibitor of voltage activated Ca2+ channels, or tetrodotoxin (TTX, 1 μM), a selective inhibitor of voltage-gated Na+ channels, had an effect on mechanically activated [Ca2+]i transients under control conditions. However, in the presence of l-NAME, both La3+ and TTX partially blocked the [Ca2+]i response. Addition of Gd3+, a blocker of mechanosensitive cation channels and L-type Ca2+ channels, at a concentration (100 μM) that markedly inhibited the mechanical response under control conditions, only partially inhibited the response in the presence of l-NAME. The combination of either La3+ or TTX with Gd3+ caused near complete inhibition of mechanically stimulated [Ca2+]i transients in the presence of l-NAME. We conclude that focal mechanical stimulation of DRG neurons causes Ca2+ influx occurs primarily through mechanosensitive cation channels under control conditions. In the presence of NOS inhibitors, additional Ca2+ influx occurs through voltage-sensitive Ca2+ channels. These results suggest that endogenously produced NO in cultured DRG neurons decreases mechanosensitivity by inhibiting voltage-gated Na+ and Ca2+ channels." @default.
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• W1978709436 date "2001-06-01" @default.
• W1978709436 modified "2023-10-11" @default.
• W1978709436 title "Nitric oxide synthase inhibitors enhance mechanosensitive Ca2+ influx in cultured dorsal root ganglion neurons" @default.
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• W1978709436 doi "https://doi.org/10.1016/s0006-8993(01)02407-6" @default.
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