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- W1978710235 abstract "The permeation of a series of structurally related compounds across silicone membranes (PDMS) was studied. The PDMS was saturated either with toluene, to mimic a functionally inert barrier, or octanol, to mimic the polar/hydrogen bonding environment of the stratum corneum lipid barrier. Phenol, salicylic acid, benzoic acid, anisole, phenylethanol and benzyl alcohol were chosen in an attempt to relate permeation to their different H-bonding capabilities. The flux was lower through the octanol system suggesting retardation by polar/H-bonding interactions. Separation of the permeability coefficient into its thermodynamic (partition coefficient) and kinetic (diffusion coefficient) terms suggests that the effect of altering polarity within the membrane has a greater impact on the diffusion of permeant rather than its chemical potential within the membrane." @default.
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- W1978710235 date "2002-02-01" @default.
- W1978710235 modified "2023-09-23" @default.
- W1978710235 title "The effect of the nature of H-bonding groups on diffusion through PDMS membranes saturated with octanol and toluene" @default.
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- W1978710235 doi "https://doi.org/10.1016/s0928-0987(01)00212-3" @default.
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