FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978711654> ?p ?o ?g. }

• W1978711654 endingPage "165" @default.
• W1978711654 startingPage "153" @default.
• W1978711654 abstract "Besides their large-scale organization in isochores, mammalian genomes display megabase-sized regions, spanning both genes and intergenes, where the strand nucleotide composition asymmetry decreases linearly, possibly due to replication activity. These so-called skew-N domains cover about a third of the human genome and are bordered by two skew upward jumps that were hypothesized to compose a subset of master replication origins active in the germline. Skew-N domains were shown to exhibit a particular gene organization. Genes with CpG-rich promoters likely expressed in the germline are over represented near the master replication origins, with large genes being co-oriented with replication fork progression, which suggests some coordination of replication and transcription. In this study, we describe another skew structure that covers ∼13% of the human genome and that is bordered by putative master replication origins similar to the ones flanking skew-N domains. These skew-split-N domains have a shape reminiscent of a N, but split in half, leaving in the center a region of null skew whose length increases with domain size. These central regions (median size ∼860 kb) have a homogeneous composition, i.e. both a null and constant skew and a constant and low GC content. They correspond to heterochromatin gene deserts found in low-GC isochores with an average gene density of 0.81 promoters/Mb as compared to 7.73 promoters/Mb genome wide. The analysis of epigenetic marks and replication timing data confirms that, in these late replicating heterochomatic regions, the initiation of replication is likely to be random. This contrasts with the transcriptionally active euchromatin state found around the bordering well positioned master replication origins. Altogether skew-N domains and skew-split-N domains cover about 50% of the human genome." @default.
• W1978711654 created "2016-06-24" @default.
• W1978711654 creator A5023201158 @default.
• W1978711654 creator A5046565506 @default.
• W1978711654 creator A5057165491 @default.
• W1978711654 creator A5063017166 @default.
• W1978711654 creator A5071155350 @default.
• W1978711654 creator A5074808031 @default.
• W1978711654 creator A5076485251 @default.
• W1978711654 date "2014-12-01" @default.
• W1978711654 modified "2023-09-26" @default.
• W1978711654 title "Large replication skew domains delimit GC-poor gene deserts in human" @default.
• W1978711654 cites W1484915261 @default.
• W1978711654 cites W1510523291 @default.
• W1978711654 cites W1535562605 @default.
• W1978711654 cites W1555438418 @default.
• W1978711654 cites W1570376951 @default.
• W1978711654 cites W18046889 @default.
• W1978711654 cites W191006495 @default.
• W1978711654 cites W1942821452 @default.
• W1978711654 cites W1963602582 @default.
• W1978711654 cites W1969461149 @default.
• W1978711654 cites W1970722699 @default.
• W1978711654 cites W1970733265 @default.
• W1978711654 cites W1972114552 @default.
• W1978711654 cites W1973075427 @default.
• W1978711654 cites W1973646952 @default.
• W1978711654 cites W1973876456 @default.
• W1978711654 cites W1974285587 @default.
• W1978711654 cites W1976050909 @default.
• W1978711654 cites W1976561295 @default.
• W1978711654 cites W1977305809 @default.
• W1978711654 cites W1977996760 @default.
• W1978711654 cites W1982126317 @default.
• W1978711654 cites W1983461014 @default.
• W1978711654 cites W1984285688 @default.
• W1978711654 cites W1987882116 @default.
• W1978711654 cites W1990905530 @default.
• W1978711654 cites W1992213480 @default.
• W1978711654 cites W1993332066 @default.
• W1978711654 cites W1993557546 @default.
• W1978711654 cites W1997378173 @default.
• W1978711654 cites W1997519837 @default.
• W1978711654 cites W2000830981 @default.
• W1978711654 cites W2003993321 @default.
• W1978711654 cites W2004391041 @default.
• W1978711654 cites W2005673755 @default.
• W1978711654 cites W2006296771 @default.
• W1978711654 cites W2009065172 @default.
• W1978711654 cites W2014078041 @default.
• W1978711654 cites W2015416439 @default.
• W1978711654 cites W2016620428 @default.
• W1978711654 cites W2018760184 @default.
• W1978711654 cites W2021523067 @default.
• W1978711654 cites W2022941383 @default.
• W1978711654 cites W2024515529 @default.
• W1978711654 cites W2026702536 @default.
• W1978711654 cites W2029746887 @default.
• W1978711654 cites W2029821231 @default.
• W1978711654 cites W2032456190 @default.
• W1978711654 cites W2036824884 @default.
• W1978711654 cites W2038359695 @default.
• W1978711654 cites W2041677039 @default.
• W1978711654 cites W2041860345 @default.
• W1978711654 cites W2042439225 @default.
• W1978711654 cites W2051045527 @default.
• W1978711654 cites W2054748846 @default.
• W1978711654 cites W2054752222 @default.
• W1978711654 cites W2057709893 @default.
• W1978711654 cites W2060789589 @default.
• W1978711654 cites W2064062763 @default.
• W1978711654 cites W2067724937 @default.
• W1978711654 cites W2068243457 @default.
• W1978711654 cites W2068289873 @default.
• W1978711654 cites W2068691391 @default.
• W1978711654 cites W2071325029 @default.
• W1978711654 cites W2072152932 @default.
• W1978711654 cites W2073010081 @default.
• W1978711654 cites W2076950513 @default.
• W1978711654 cites W2080116079 @default.
• W1978711654 cites W2081229967 @default.
• W1978711654 cites W2083886963 @default.
• W1978711654 cites W2084811431 @default.
• W1978711654 cites W2085666970 @default.
• W1978711654 cites W2087209125 @default.
• W1978711654 cites W2087627409 @default.
• W1978711654 cites W2090037139 @default.
• W1978711654 cites W2090098862 @default.
• W1978711654 cites W2091658754 @default.
• W1978711654 cites W2091957391 @default.
• W1978711654 cites W2092464006 @default.
• W1978711654 cites W2096254048 @default.
• W1978711654 cites W2100238259 @default.
• W1978711654 cites W2101412414 @default.
• W1978711654 cites W2101553331 @default.
• W1978711654 cites W2101768075 @default.
• W1978711654 cites W2102599158 @default.
• W1978711654 cites W2106448802 @default.

• next