FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978711808> ?p ?o ?g. }

• W1978711808 endingPage "e82232" @default.
• W1978711808 startingPage "e82232" @default.
• W1978711808 abstract "Halofuginone (HF) is an active component of extracts derived from the plant alkaloid febrifugine and has shown therapeutic promise in animal models of fibrotic disease. Our main objectives were to clarify the suppressive effect of HF on concanavalin A (ConA)-induced liver fibrosis. ConA injection into the tail vein caused a great increase in the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, while orally administration of HF significantly decreased the levels of the transaminases. In addition, the levels of hyaluronic acid (HA), procollagen III (PCIII) and TGF-β1 in the serum and collagen I, α-SMA, tissue inhibitors of metalloproteinase 2 (TIMP2) and Smad3 in the liver tissue were significantly lowered with the treatment of HF. Histological examination also demonstrated that HF significantly reduced the severity of liver fibrosis. Since ConA-induced liver fibrosis is caused by the repeated activation of T cells, immunomodulatory substances might be responsible for the suppressive effect of HF. We found that the production of nuclear factor (NF)-kB in the serum was increased in ConA-treated group, while decreased significantly with the treatment of HF. The changes of inflammatory cytokines tumor necrosis factor (TNF-α), IL-6 and IL-1β in the serum followed the same rhythm. All together, our findings indicate that orally administration HF (10ppm) would attenuate the liver fibrosis by suppressing the synthesis of collagen I and inflammation-mediated liver injury." @default.
• W1978711808 created "2016-06-24" @default.
• W1978711808 creator A5006530156 @default.
• W1978711808 creator A5011153171 @default.
• W1978711808 creator A5043285407 @default.
• W1978711808 creator A5043784736 @default.
• W1978711808 creator A5061388769 @default.
• W1978711808 creator A5076981458 @default.
• W1978711808 creator A5080256378 @default.
• W1978711808 creator A5091860889 @default.
• W1978711808 date "2013-12-16" @default.
• W1978711808 modified "2023-09-25" @default.
• W1978711808 title "Preventive Effect of Halofuginone on Concanavalin A-Induced Liver Fibrosis" @default.
• W1978711808 cites W1894541755 @default.
• W1978711808 cites W1968798984 @default.
• W1978711808 cites W1971890973 @default.
• W1978711808 cites W1976777085 @default.
• W1978711808 cites W1977076453 @default.
• W1978711808 cites W1977168314 @default.
• W1978711808 cites W1980325398 @default.
• W1978711808 cites W1983426248 @default.
• W1978711808 cites W1986601339 @default.
• W1978711808 cites W1992857831 @default.
• W1978711808 cites W1998004099 @default.
• W1978711808 cites W1998976242 @default.
• W1978711808 cites W2002043123 @default.
• W1978711808 cites W2005008773 @default.
• W1978711808 cites W2006626994 @default.
• W1978711808 cites W2010237936 @default.
• W1978711808 cites W2010431766 @default.
• W1978711808 cites W2013322971 @default.
• W1978711808 cites W2031302730 @default.
• W1978711808 cites W2035653659 @default.
• W1978711808 cites W2041673115 @default.
• W1978711808 cites W2046629430 @default.
• W1978711808 cites W2047485743 @default.
• W1978711808 cites W2048221993 @default.
• W1978711808 cites W2048776432 @default.
• W1978711808 cites W2049941037 @default.
• W1978711808 cites W2060610804 @default.
• W1978711808 cites W2072443750 @default.
• W1978711808 cites W2073653948 @default.
• W1978711808 cites W2077388392 @default.
• W1978711808 cites W2089221443 @default.
• W1978711808 cites W2091073883 @default.
• W1978711808 cites W2096068924 @default.
• W1978711808 cites W2098477897 @default.
• W1978711808 cites W2099477838 @default.
• W1978711808 cites W2104193042 @default.
• W1978711808 cites W2122869582 @default.
• W1978711808 cites W2124034233 @default.
• W1978711808 cites W2124532149 @default.
• W1978711808 cites W2130792045 @default.
• W1978711808 cites W2136255250 @default.
• W1978711808 cites W2137421304 @default.
• W1978711808 cites W2138066441 @default.
• W1978711808 cites W2139573671 @default.
• W1978711808 cites W2147758809 @default.
• W1978711808 cites W2155772701 @default.
• W1978711808 cites W2156398854 @default.
• W1978711808 doi "https://doi.org/10.1371/journal.pone.0082232" @default.
• W1978711808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3864948" @default.
• W1978711808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24358159" @default.
• W1978711808 hasPublicationYear "2013" @default.
• W1978711808 type Work @default.
• W1978711808 sameAs 1978711808 @default.
• W1978711808 citedByCount "31" @default.
• W1978711808 countsByYear W19787118082014 @default.
• W1978711808 countsByYear W19787118082015 @default.
• W1978711808 countsByYear W19787118082016 @default.
• W1978711808 countsByYear W19787118082017 @default.
• W1978711808 countsByYear W19787118082018 @default.
• W1978711808 countsByYear W19787118082019 @default.
• W1978711808 countsByYear W19787118082020 @default.
• W1978711808 countsByYear W19787118082021 @default.
• W1978711808 countsByYear W19787118082022 @default.
• W1978711808 countsByYear W19787118082023 @default.
• W1978711808 crossrefType "journal-article" @default.
• W1978711808 hasAuthorship W1978711808A5006530156 @default.
• W1978711808 hasAuthorship W1978711808A5011153171 @default.
• W1978711808 hasAuthorship W1978711808A5043285407 @default.
• W1978711808 hasAuthorship W1978711808A5043784736 @default.
• W1978711808 hasAuthorship W1978711808A5061388769 @default.
• W1978711808 hasAuthorship W1978711808A5076981458 @default.
• W1978711808 hasAuthorship W1978711808A5080256378 @default.
• W1978711808 hasAuthorship W1978711808A5091860889 @default.
• W1978711808 hasBestOaLocation W19787118081 @default.
• W1978711808 hasConcept C105702510 @default.
• W1978711808 hasConcept C126322002 @default.
• W1978711808 hasConcept C134018914 @default.
• W1978711808 hasConcept C142724271 @default.
• W1978711808 hasConcept C17991360 @default.
• W1978711808 hasConcept C185592680 @default.
• W1978711808 hasConcept C19869320 @default.
• W1978711808 hasConcept C202751555 @default.
• W1978711808 hasConcept C2776637226 @default.
• W1978711808 hasConcept C2776914184 @default.
• W1978711808 hasConcept C2777529286 @default.

• next