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- W1978714014 abstract "Molecules encoded by the major histocompatibility complex (MHC) are polymorphic integral membrane proteins adapted to the presentation of peptide fragments of foreign antigens to antigen-specific T-cells. The diversity of infectious agents to which an immune response must be mounted poses a unique problem for receptor-ligand interactions; how can proteins whose polymorphism is necessarily limited bind an array of peptides almost infinite in its complexity? Both MHC class I and class II determinants have achieved this goal by harnessing a limited number of peptide side chains to anchor the epitope in place while exploiting conserved features of peptide structure, independent of their primary sequence. While class I molecules interact predominantly with the N- and C-termini of peptides, class II determinants form an extensive hydrogen bonding network along the length of the peptide backbone. Such a strategy ensures high-affinity binding, while selectively exposing the unique features of each ligand for recognition by the T-cell receptor." @default.
- W1978714014 created "2016-06-24" @default.
- W1978714014 creator A5055035597 @default.
- W1978714014 date "1998-05-01" @default.
- W1978714014 modified "2023-09-27" @default.
- W1978714014 title "Presentation of antigenic peptides by products of the major histocompatibility complex" @default.
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- W1978714014 doi "https://doi.org/10.1002/(sici)1099-1387(199805)4:3<182::aid-psc144>3.0.co;2-s" @default.
- W1978714014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9643627" @default.
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