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• W1978714073 startingPage "249" @default.
• W1978714073 abstract "Two types of aggregated tubules derived from, and continuous with, elements of sarcoplasmic reticulum were observed in degenerated cardiac muscle cells from patients with cardiac hypertrophy. Aggregates of the first type, found in 2 patients, were composed of long, parallel tubules which measured from 500 to 1130 Å in diameter and showed different degrees of organization. In some of these aggregates the tubules were irregularly arranged and were closely associated with large masses of abnormal Z band material to which thin myofilaments were attached. In other instances, the tubules formed highly regular, hexagonally arranged aggregates; the spaces between these aggregated tubules contained thin myofilaments and small amounts of Z band material. Cells in which these aggregates were present showed advanced degenerative changes characterized by disarray of myofibrils, absence of T tubules, and selective loss of thick myofilaments. It is concluded that the formation of these aggregates of tubules derived from the sarcoplasmic reticulum is a degenerative change related to the inability of the sarcoplasmic reticulum to form meshworks around abnormally constituted myofibrils, or terminal cisterns around T tubules. Aggregates of the second type, found in one patient, were formed by long, straight, irregularly arranged tubules that measured 500 to 830 Å in diameter and were not associated with myofibrillar components. These aggregates are considered to represent an unusual type of proliferation of the sarcoplasmic reticulum in cells having normally arranged contractile elements." @default.
• W1978714073 created "2016-06-24" @default.
• W1978714073 creator A5048131213 @default.
• W1978714073 date "1974-06-01" @default.
• W1978714073 modified "2023-09-23" @default.
• W1978714073 title "Aggregates of tubules in human cardiac muscle cells" @default.
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• W1978714073 doi "https://doi.org/10.1016/0022-2828(74)90054-6" @default.
• W1978714073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4837896" @default.
• W1978714073 hasPublicationYear "1974" @default.
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