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• W1978720404 abstract "The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) is known to modulate viral and cellular gene expression. We show that LANA directly associates with an interleukin-6 signal transducer, signal transducer and activator of transcription 3 (STAT3) and that LANA enhances the transcriptional activity of STAT3. Coimmunoprecipitation studies documented a physical interaction between LANA and STAT3 in transiently transfected 293T cells as well as the KSHV-infected primary effusion lymphoma (PEL) cell line. Furthermore, small-interfering RNA-mediated reduction of LANA expression decreased the STAT3-dependent transcription in KSHV-positive PEL cells, whereas overexpression of LANA enhanced STAT3 activity in KSHV-negative B lymphoma cells. These data demonstrate that LANA is a transcriptional co-activator of STAT3, and may have implications for the pathogenesis of KSHV-associated diseases." @default.
• W1978720404 created "2016-06-24" @default.
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• W1978720404 date "2005-12-06" @default.
• W1978720404 modified "2023-09-25" @default.
• W1978720404 title "Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA" @default.
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• W1978720404 doi "https://doi.org/10.1016/j.febslet.2005.11.057" @default.
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